Conserved Protein Domain Family
ANAPC1
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pfam12859: ANAPC1 (This model is not part of the current CDD release)
Anaphase-promoting complex subunit 1 WD40 beta-propeller domain
Apc1 is the largest of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Infection of human fibroblasts with human cytomegalovirus (HCMV) leads to cell cycle dysregulation, which is associated with the inactivation of the anaphase-promoting complex. Apc1 consists of a N-terminal WD40 beta-propeller domain, a middle domain (Mid-N), a PC domain and a C-terminal domain (Mid-C) that coalesces with Mid-N to form Apc1Mid which connects Apc1-WD40 with Apc1-PC and comprises an alpha-solenoid capped by a beta-sandwich. The N-terminal domain is essential for APC/C catalytic activity as it mediates the coactivator-induced conformational change of the APC/C which promotes UbcH10 binding.
Links
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Statistics
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PSSM-Id: 520493
Aligned: 37 rows
Threshold Bit Score: 232.788
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003841604   29 SERDYTWQAFttaeaT--------------------DS--------DSPIDELVTTDYHVVWSRGGVIRKVFSFEVDKEK 80  
7_pfamImport    1 VSDSYEYFLFdphltGqgndgdg-----------------neanfsrQREHELFIRHNRIIWTSGSRVLKRFTL---SSP 60  
1_pfamImport    1 VTDKYDYFLFdpdivRdrdemnds--------------disaspfsDQCDHELFIRGNRIIWSTGSRVFKRFTS---PSP 63  
XP_006843625   34 RPEDYQYSLFnpqitRdprflaen---------------svtsascdQSDHEIFIRGNRLIWSAGSRVHKRYTS---PTS 95  
3_pfamImport    1 TNPAIDFSALiigqpNpppikpffhlfnsnlisnqiTEkdlqcqdaLRLDQEAYVHGRTVVWSRGGYVVKTLDYSLEPQA 80  
XP_003848469   29 RPERYQWETFmva------------------------------dgeEQTEEEILTTEHAVVWSQGSFVRNVFRFDVEGEI 78  
XP_007672669   29 REDSYRWETYicn------------------------------dgdVILDEELLTTQDCVVWSQGCYIRSVYRFGLEGED 78  
5_pfamImport    1 SPDAYTWSTYs----------------------------------dDEGEEEVTATEYCVVWSRGGIIRKVYNFEVEGEK 46  
KAL0140274     72 ERGLYDSGKLyn--------------------------------paLQLEQEVYVRGSTVVWSRAGCVIKTFDYSAEIQP 119  Mucor lusitan...
XP_015640103   36 PPQDYDYFLFdpalaAspapepgee--------------aassssgaDGDHELFIRGNRIIWSAGSRVHKRYLS---PNT 98   Japanese rice

XP_003841604   81 VIQALLTWFPVEEA-------------------------------SHAAAATAATTTEAAAGVAAEHHGqDlsksfltqg 129 
7_pfamImport   61 IIKACWSHLGRGP------------------------------------------------------------------- 73  
1_pfamImport   64 VKMACWCHLGEMS------------------------------------------------------------------- 76  
XP_006843625   96 IAMACWCRMDSIS------------------------------------------------------------------- 108 
3_pfamImport   81 IQKVLFAKFFVDAF-------------------------------KVGKQATGTTEEESKGGSSDESSQsEh-------- 121 
XP_003848469   79 VTQAILTTFPSDRA-------------------------------GDGTNAEAs-------------------------- 101 
XP_007672669   79 VRQAILTSFPSVTQ-------------------------------EVHPPSETTSQTHWQPIGREQGVRpLsndetrn-- 125 
5_pfamImport   47 VLQAVLTWFPSDDA-------------------------------AALRNTTQDLRQDHGPGTLFVKDRiRergypahed 95  
KAL0140274    120 IQQVLFAWFPVTSAffkndptnkpaidavlndfegdkylvegywdKKGPQSIINLKNAATSKDDDGEEEtDpvrqmrpln 199  Mucor lusitan...
XP_015640103   99 VIMACWCRMDKTR------------------------------------------------------------------- 111  Japanese rice

XP_003841604  130 tqpatdpnapvdttpptievrSRALVVFLRSQ-AHVFFLSGATHI-VNLPFEVDKAFPAARGLVVQRKLAsPRtaaASSp 207 
7_pfamImport   74 ----------------------EAFLCVLQIGcLTVYSTSGE-VVsVPLSRTVISIWPLPFGLLLQQAAEvnqs------ 124 
1_pfamImport   77 ----------------------EALLCILQIDsLTIYNISGE-VVsIPLPCTITSIWPLPFGLLLQPAAEgssp------ 127 
XP_006843625  109 ----------------------EPLLCVLQDDsLTIHSPSGE-VVsVPLPFAVVSIWSSAFGLLLQRSIDdslp------ 159 
3_pfamImport  122 ---------------------yKALCVVFKD--YIIICREEATSItCHVPFDIGEVVPLDIGLIISRSYEp--------- 169 
XP_003848469  102 --------------------pARALVVLLRTK-AHIYFLQGSHHI-VDLPFEVERAFQAPRGLLLQRKRT-SPnslPPSp 158 
XP_007672669  126 ---------------gektgssRALVVVLKTK-LHVYFLSGAQHI-IDLPFEVERAFPAPHGCILQRKSA-ALmepPHTp 187 
5_pfamImport   96 rgts-----krpasgvqaeklSRALVVFLKTQ-AHVFFLAGSSHV-VNLPFEVERVFPAPRGLLIQRKMS-IPdfiPASp 167 
KAL0140274    200 nip--------eidekddslqrRTLCIVFQDC-IKLHCEDGI-HVtAHIPFEIDHVVPLDMGVLVSRKYV---------- 259  Mucor lusitan...
XP_015640103  112 ----------------------DALLCVLQVDtLSIYNVNGE-VAsIPLPYAVSSIWPLPSGLLLQKSTDgg-------- 160  Japanese rice

XP_003841604  208 SIPSAPPNsfltanqSFLsq----sFSQSFSp----------TLHRHAGSLGGSRPGKSRLSGPat-fLDDMINPVTa-L 271 
7_pfamImport  125 ----------------------shiPFSSATptl-----asrEMLRQRKETGNISPQNFHSSVA----HELT-------S 166 
1_pfamImport  128 ----------------------mqsTFLSTNpll-----garDISSLRREIGHSPQQNVTFSNA----FDNV-------I 169 
XP_006843625  160 ----------------------scpTFSSYSpll-----narDSFRLNRESGVGPQYNLSVHGS----SGHN-------F 201 
3_pfamImport  170 ------------------------------------------KLDRKRKAKSALAQSTLTSSKIprsrLTKT-------P 200 
XP_003848469  159 QMPSVPPN-------SFFfs----qARMRTSmsfldcptlqkSFAGSKRILSNPTSGDSKLEALfqtiTAAS-------G 220 
XP_007672669  188 QVPAVPPN-------SFLf------sRSQTSasylqsptlqrSLGGSVAVKANPPGTAGGLDAL----LKEVFGRPAe-G 249 
5_pfamImport  168 AVPKAPPN-------SFFsqlptqsFSQNSSl----------FTPMTNTSFAAPRRSRSGLSTAypssLSDL---LKlgT 227 
KAL0140274    260 -------------------------------------------PDKWKRSAGRPRSSSITNLASlaagMKK--------P 288  Mucor lusitan...
XP_015640103  161 -----------------------hmVLSSTSllk------srDLIRPNKEFGLNYNVSSQVNTL---------------E 196  Japanese rice

XP_003841604  272 NQET-----IPRLYSFTDPLSELGLVVNVIaGGERAGLLTTngsshRKLEAMDKAEEVVYVSPQNE------VLFDRSGn 340 
7_pfamImport  167 RRD------MSSHLILRDPLEE---------------------------------PEPIYLEERGKlnimkdYDERTIWt 207 
1_pfamImport  170 KADTv---tLSSHLILKDLLEE---------------------------------PQSTYIEERGKlnimkdFDEKTIWt 213 
XP_006843625  202 IGDIs---tMSSHFILKHPLEE---------------------------------PQAIFVEERGKscimndLEESIIWt 245 
3_pfamImport  201 SDSFe---mTSSFVTITNPLREACPVRPKDmNRIGASTLPL---------PFTDPQKVLFATTSASns------------ 256 
XP_003848469  221 KRGDd---dVTNLYSLSGPLSDLGVVTYSLqHQKPRMNGRSqngnsVEFEGLDPAEKIIYVSPEDE------LSSTDKGk 291 
XP_007672669  250 IDLN-----SALLYTMSDPLSDMAVVTCSFqHRKARVSGGHeyrsaVDFEYLDAAEELIYVSANSE------VATSSPPg 318 
5_pfamImport  228 SPSAd---gLPRLFSFTDPFSEMGLVVASQsSAAKSSWSVRqs-gsRTLEPVDKAEEVLYVTKHNE------MSDSDSPa 297 
KAL0140274    289 PSSEd---tSSFFVTVTHPLKGACPVKSKDvHHNGISTLPE---------PLTSPQRLLFATTKVAdt------------ 344  Mucor lusitan...
XP_015640103  197 TVSKadgaiFSSHLILKHPLEE---------------------------------PQATYFEEWGRldmmkdFDEKTIWt 243  Japanese rice

XP_003841604  341 dkPLLLVITANPETNVFTIWSAAYLEPKSIST------SRKQHAhvpmnkHRRRSSHGa-tA--PGTGAT-TPA------ 404 
7_pfamImport  208 sdRLPLMTSYNKGKMQHSVWA----------------------------------------------------------- 228 
1_pfamImport  214 sdQIPLMASYNKGKLQHSVWV----------------------------------------------------------- 234 
XP_006843625  246 sdAIPVIATYHKGKMQHSVWR----------------------------------------------------------- 266 
3_pfamImport  257 -gRLPVIVTLNMNDKRHYVWT-----------------------------YDRRKNKGkvpNqtENNPSTrSLAlskkrh 306 
XP_003848469  292 sgPLVLLVTLNTDIHTITIWHAWYVDEKSLQDllkhrkEQEEVK------ARRRSSFLsagV--AATGTT-TPA------ 356 
XP_007672669  319 sgELMLLVTFNTVLQIVNVWHAYYLDEKSLKTlmkqraTSKAAQ------ARRRNSFMs-tA--AGTGTT-TPA------ 382 
5_pfamImport  298 dkPLILVVTVNYERRIYSVWHASYIDPRPASAk----kSRRSSTtlsvgrSRRRSSLH------PGTGAT-TPA------ 360 
KAL0140274    345 -gRLPVIVTLNIKENRHYIWT-----------------------------YERRKE--------KNQQAIpAPAnmmppv 386  Mucor lusitan...
XP_015640103  244 sdIVPLMASYHKGKFQHSVWQ----------------------------------------------------------- 264  Japanese rice

XP_003841604  405 ----SRg-AD-RLRESFGga-----------prSKTQPPSLkqat--qsqERLSdqAVEDaLASQLN-PDS--DMARQP- 461 
7_pfamImport  229 ----------------------------------------------------------AEfIDSNREaSAScsSGVAPDt 250 
1_pfamImport  235 ----------------------------------------------------------VEvINSNLEdANAssIDEIPTg 256 
XP_006843625  267 ----------------------------------------------------------VDiVDASVTiASSllVKDFVVe 288 
3_pfamImport  307 ketlPEn-SApKKKQRMLhgakl----------------------fqegyHSDEdtLLEDeVEKAIY------NEILDPs 357 
XP_003848469  357 ----VRr-RD-GARESFAagglanl--plpgdtAVTQAGGVprkp-----------teeEvMASQMD-PDYvpALSQQPa 416 
XP_007672669  383 ----VRt-RDhNARESFAaagsir----mpgdpHTSHSTATaprpglrsnDE-------EaMVKQMD-PEFqlPASQQVl 445 
5_pfamImport  361 ----LRt-RE-GTRDSFGgp------------gRGYGTSSFtasq--trePSGEqqTAEEaFASQLD-PET--DLARQPa 417 
KAL0140274    387 krkpHHshAApPVRKKVKsgapphvsrnkkhqhQKMGSPSRshaqfhedyVSDEevLHENeVEKDIY------NEMLDPs 460  Mucor lusitan...
XP_015640103  265 ----------------------------------------------------------IDgTTYQEE-INDnaVPPIPCd 285  Japanese rice

XP_003841604  462 KESRRVSSLLSRAEL--STSFDKSAFQDMATSrnslGGSfstsfgASQRsrRSMGHD--RTSLgg--afSHSRHRASTpg 535 
7_pfamImport  251 VFPKRVSF---RRIWqaKGAKKAAS------------------------------------------------------- 272 
1_pfamImport  257 VVAKQFSL---RRIWqgKGAQAAAC------------------------------------------------------- 278 
XP_006843625  289 EQSKAYCL---HKIWqgRSAQPVAS------------------------------------------------------- 310 
3_pfamImport  358 EISIRLLWk--------ETHTQRTStk----------------------------------------------------- 376 
XP_003848469  417 RENRRISSM--NTDVrgSQMTVNASFGS-----------------TGGRraTSFGGPaeRRSL------SHRKSRGSTpg 471 
XP_007672669  446 REGRRISSL--NADMrtSQTAAVNSFAS-------------------GRrnASFGGAgdRRSL------GIRKSRGSTpg 498 
5_pfamImport  418 KESRRVSSLLSRADL--SRSFDKSAF-EQATHrsslGSNf-----SHSRrgPSFGGQglRTSLgpssrpTSRKARASTpg 489 
KAL0140274    461 EISLRLLW---REPAykMPAKLKTSrk----------------------------------------------------- 484  Mucor lusitan...
XP_015640103  286 ISMHKFAF---RKIWqgKCSQSAAS------------------------------------------------------- 307  Japanese rice

XP_003841604  536 SITS---------------RM-Sl----GAASIDDP--LEDTMDEDTF-DTIEDHDELDDLfappdgtaeprpgDGLHKE 592 
7_pfamImport      --------------------------------------------------------------------------------     
1_pfamImport      --------------------------------------------------------------------------------     
XP_006843625      --------------------------------------------------------------------------------     
3_pfamImport      --------------------------------------------------------------------------------     
XP_003848469  472 STYSrsvagdddsimdldsTIeId----DEESADGI--LRHIRATFEA-SGADSVFGSTD--------------DGFKRE 530 
XP_007672669  499 SVFArslgrdd-demdldsDDnAg----REGTVEVI--LRHMRATFEA-AGADSLFGDLD--------------QNGRRD 556 
5_pfamImport  490 DV-----------------SQiSlsavsLEDTLDDDldLDDTIDDSEIpDELLGGDGDDTSglq-------epiEGLRRE 545 
KAL0140274        --------------------------------------------------------------------------------      Mucor lusitan...
XP_015640103      --------------------------------------------------------------------------------      Japanese rice

XP_003841604  593 LVTSVIAEIPVTQylrhgLFTLSnp-snPEDQPQCKIVALNAP--FNSATLHERKLYLYISHSSLQEPLEIELAVTRKRL 669 
7_pfamImport  273 -----------------------------------KVFLATDDa----------VPVICFLILEQKKLLSVGLQTVEINN 307 
1_pfamImport  279 -----------------------------------KVFLATDDd---------aAPVLCFLLQEQKKLLSVRLQSLAINN 314 
XP_006843625  311 -----------------------------------KVFLATDVd---------eVPLICFVFQEQKGLFFIRLQTGARHK 346 
3_pfamImport  377 --------------------------lkGLGIIESKAFLVHDLh---------gQELVCILNHSLGYLQLINLDMASCST 421 
XP_003848469  531 LIVRKIHSFPVGS-------LSAsrgmaEVPVGMHKVVTL--PemQSNNGVSSTKINVYIHDRQSRGAQVLTLRVKQRPL 601 
XP_007672669  557 LVVRKVHSYRVDR---------------ETAASGLKVVVL--RdtRLDLNEQQTKVNVYILDRMTKEVRRLVLQVTKRQL 619 
5_pfamImport  546 LLLVKFSEIPFGT-----SESIFhssvhGKPMDLPKVFTLKAPrsFTDAYPNDGRFFLYMMQRSKGELVEHEFTVQRRRL 620 
KAL0140274    485 --------------------------vnS------EAFLIHDLn---------gQELICIVNHSMGHLQVINLAKATHLV 523  Mucor lusitan...
XP_015640103  308 -----------------------------------KVFLATDId---------gTPIICFLLHEQKILLAVRFQVDENNG 343  Japanese rice

XP_003841604  670 SPSASATQSKSSIVAPRYACVPRYVGIRRLEGARDLVKLRDGCVERVALLTSTEPHEPCLSLTAGWGS------------ 737 
7_pfamImport  308 EILFDVKPDISWSVSAIAAAPVVVTRSQVKNGLLPHLD--------IIVLSPEND----LVLYVGKQC------------ 363 
1_pfamImport  315 EIIFDVKPDMSWSISATAAAPVIITRPRVKAGLLPYSD--------IVVLAPENT----LLLYSGKQC------------ 370 
XP_006843625  347 EILYDMKPDMNWTIPAIAALPVVVTRPRIKDGWLQLSD--------VLVLSTENN----LLLYSGRQC------------ 402 
3_pfamImport  422 N------RCIAFKTFAKFAAPVYATRDRHID---------------LLMIDPENN----LRLYIDRSIdkftiklpgdav 476 
XP_003848469  602 WPETANpv---------nvAIPLLVSENGIANCDDILRLQDSNMRAVLL--------GSKGIQFSLDE------------ 652 
XP_007672669  620 WPELHRtt---------qvAVPVLLSDCISGQASDIVKISCPTTEAVLL--------GERGLVLSNSD------------ 670 
5_pfamImport  621 TPMPA-SSVGSKTKEPCNILIPTGVNTQRQRSYIDAAKVCDNGIQRVLCLARDNSGNCVFSLFAGWCP------------ 687 
KAL0140274    524 T------NCIEMKIPAKSAVPIHATRDGYSD---------------LLFLDASNR----LQLFIDASMkcipl--rmsgh 576  Mucor lusitan...
XP_015640103  344 ESFGDIKPHMSWNIPALAAAPVVVTRPRAWAGVLPFTD--------ILILTPDND----LLLYSGKQC------------ 399  Japanese rice

XP_003841604  738 HLPMKISL-GPirlFDPYAI-LQDNQTRATAGSKRTI----LATKPLRHVVSLGAKGKFELIDGEYRRHRFEVRLSPEDR 811 
7_pfamImport  364 LCKYVLPSgFG------KNLvSGDRESAEKDSGPRDLkitgLSDA---------VLGCINLSVNHSQIFRCALTGSPSSS 428 
1_pfamImport  371 LCKYFMPSsLG---------------------KSHDLkilgLADA---------VEGRVNLITNNGQMFRCALRRNPSSS 420 
XP_006843625  403 LCKYLLPTgIG------RV---SHDVKPLPSDVVREFkitgLGDA---------VGGRINIIISGGQMFRCSLRNYPMSS 464 
3_pfamImport  477 PVKILDP-----------------------------------------------LYDRFTIQYDNNKMYRFQLDLRPCSS 509 
XP_003848469  653 QPLCSLPApATyrvYNPLSLrSQSGQSDKEVGRNRLL----APPAAPLYLQHEGTHGAYDEVSQDGVHHRRRLSLRPSHQ 728 
XP_007672669  671 NVVCTMPQrAAyrvYP--KYdATAVPRNEDYGSNRTV----DVPNAGLSFGHSSAEGQYDEIDLSGTHHRRRLILQTEDP 744 
5_pfamImport  688 RARITLPLpRRfrvFNPYAVgISVALQRGIGDVDRTI----EVPQNLIALAHSATDGLLDVREDNSRQHRLQIKLWPQNS 763 
KAL0140274    577 ATKLIDP-----------------------------------------------VYDRFTAVTEKG-MIRCQLHGRPETS 608  Mucor lusitan...
XP_015640103  400 LCRYTLPTeLG------KGIfSNYELNSGVTEFYSDMeitsITDA---------VEGRINVTCSNGLMLRCSLRKSPSSS 464  Japanese rice

XP_003841604  812 MVAELFRVLCTVLP----SYTGDFLLEIWWNIRKLLST-------ENQEsQSRDWYAFVATV 862 
7_pfamImport  429 LANDCIAALAEGLQsdlyNLFLSLLWG----------Ddn---sdQKGScVHFEWEAFCNIF 477 
1_pfamImport  421 LVKDCITAMAEGLTssfyNHFLVLLWG----------EndsdylsRADStVDSEWDSFSSVI 472 
XP_006843625  465 LANDCITALAEGLHpsfyHHFVVMLWG----------NggssclsSAESsTDSEWESLVSVI 516 
3_pfamImport  510 LVRECLIAVdc-----gsTNDFPRIWRCFLDACFFLQQ--------PSDmNVNEWKTFVVIF 558 
XP_003848469  729 HIDDLLSVCEYVLP----KQQARALRKTWCMAYAWLSShq---enLTATkCDAEFVAFVATL 783 
XP_007672669  745 LIHRLLGALELVLP----TQQASLVRSVWCMAYSWLDQrp---ecLAATaCGIEWTALATTT 799 
5_pfamImport  764 TVSNVLSVCRLVLP----PPQGDHLLAIWWNISRNMKN---------EMrFDVEWAALVASI 812 
KAL0140274    609 LVRDCFAAIdc-----anTLYFPTILARFLSLQETPPD--------DDRlCISEWENFFVAL 657  Mucor lusitanicus
XP_015640103  465 LVGDCITAMAEGLQscfySHFVSLLWGdsda-----------aylCSSShVDSEWESFSYEV 515  Japanese rice
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