Conserved Protein Domain Family
Ecl1

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pfam12855: Ecl1 (This model is not part of the current CDD release)
ECL1/2/3 zinc binding proteins
This family is involved in the chronological life-span of S. cerevisiae. Over-expression leads to an extended viability of wild-type strains, indicating a role in regulation. There are four cysteine residues conserved in the N-terminal region involved in zinc binding and have been shown to be essential for protein functions. Ecl1-family proteins are essential for sexual development caused by zinc depletion in S. pombe. They are also important for cellular response to zinc limitation.
Statistics
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PSSM-Id: 520492
Aligned: 60 rows
Threshold Bit Score: 47.1061
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCD55860      87 GESFPQFCMTCEKQFtPPNNTFLYCSEQCRVHDqaptyTSRSNPYATAPNs------P-------PLTPFls---saTLY 150
Q2GVR0       102 FDWEHQFCLGCDKQT----DGATYCSESCRLAD-----YEKTSPSTPSSA---------------ASSPAl--------- 148 Chaetomium glob...
XP_003666851 104 FDWEHQFCLGCDKQT----DGATYCSESCRLAD-----YERTSPSSPSSVvssaagsP-------ASSSF-------PSD 160
8_pfamImport   1 MEWSPDFCLACDRQT----DGSVYCSEACRLAE-----YEKASSSDSSA----------------PSSPS-------SLH 48 
KIN05655       2 MEWSLDFCLPCDKQC----DGHVYCSEACRLAE-----YEKPSSTAGSAAs------S-------PVTPRg------PVS 53 
XP_018191110   5 MEWSPDFCLACDRQS----SGGAYCSQACRLAD-----IEKASGSSE------------------PVSPS---------S 48 
XP_018287905   1 MICDTNWCTYCDSAV-SPFSDSLYCSEECLKKD-----ALAHH----------------------PMLGY---------- 42 
OAC98601       1 MMCDTNWCTFCDNAI-SPYSDSLYCSEDCLRQDal--mHHPMLGYDYAELe--------------GFPHS---------- 53 
GAN02510       1 MMCDTNWCTFCDNAI-SPYSDSLYCSEDCLRQDal--mHHPMLGYDYAELe--------------GFPHS---------- 53 
KXS13076       1 MDYLTAWCIECGRSC--PEGNSAYCSDSCRDADlaraaAKHSLYCDSDGFap----sPihapahaSHAPKalltnvfRSA 74 
CCD55860     151 SPEEPrdiv-prlSPTQSRPrsyfnsspyptdysvSYHVPSSslPASHFYTSSQADTYSssaleslrelatalpRTHQPH 229
Q2GVR0       149 -------------SGPPPDW----------------TLSRPT--TTSNTKFYLSPAYd---------------fGLAQPS 182 Chaetomium glob...
XP_003666851 161 WTLSSsstaynnsTKFYLSPay-------------dFALAQS--SSRRGSTQIQTLS----------------------- 202
8_pfamImport  49 GAAWPsk-----sNGFYMEPay-------------nFSNAQP--YGTTPSSTTSFYQPS-----------------RSSP 91 
KIN05655      54 WPATRs------hHGFYMEPay-------------nFRKAQP--YGTTPTRSDFSSLVR-----------------THAP 95 
XP_018191110  49 WSSPVfe----hgTGFVLPPpldfdayrsarrasrLSAGRQS--SSSSSPESPHDSYFP----------------LMPAA 106
XP_018287905  43 -------------DFIDLRS----------------FPR-----NNNQDGSRDAPFETR--------------------- 67 
OAC98601      54 -------------TQMPSLVr--------------RKSSIPT--LAANSSSSSSSTDFI--------------------- 83 
GAN02510      54 -------------TQMPSLVrr-------------kSSIPTL--AASSNSNSSNSTDFI-----------------QLQK 88 
KXS13076      75 RTSPR--------STLPLPSlplpl------ssplPPLPPLP--TSSFPTATSTPTTTS-------------------FP 119
CCD55860     230 EPesppTTTLSrtssq---vwnymPFTTKTTTPTplvtpgns---ysnsgasHSARRSREDLYSFGASQTFTNTggm--g 301
Q2GVR0       183 TR----RGSTQtl----------sPSASHTSLCS----------------------MRSNSSAGLDAAQLSEKA------ 220 Chaetomium glob...
XP_003666851 203 ------------------------PSASHASLCS-------------------------MRSNSSAGLDATQLSek---- 229
8_pfamImport  92 VT----KSTLT-------------PSSSQSSLFS-------------------------MQSTSSTSSEPAQLSae---- 125
KIN05655      96 ST----RTVLT-------------PSSSQSSLFS-------------------MQSASSTASSASEPAQLSDDA------ 133
XP_018191110 107 RPslssISGLDkl----------tPSSSRTSLSS------------------------VGRPSTPDNGALSDKA------ 146
XP_018287905  68 ------RRSTC-------------SMSSQGIPGL------------------------ISHSACVSANSSLGYS------ 98 
OAC98601      84 ------QLQKI-------------PSLSPSLSSS-----------------------ISSYSSVHPCDTNADFN------ 115
GAN02510      89 IP----SLSPSlss--------siSSYSSAHPCD--------------------------------TNADFNKS------ 118
KXS13076     120 HL----HLVSNtgkrrtwclrdpvPPGVFAELQRavvagwdegdvrvemiaaELCEAALAGDLSLSAGSDARWSssqsss 195
CCD55860     302 mDRPLPPRSGPGG--YVHR-PRs---iDLVTP 327
Q2GVR0       221 -ARELRAYAR-----SFES-VR------LQRR 239 Chaetomium globosum CBS 148.51
XP_003666851 230 aAKELRAYAR-----SFES-VRl----QRRRS 251
8_pfamImport 126 sKRALRAYAS-----SFDQ-SRn----NRRQS 147
KIN05655     134 -RKALRAYAS-----SFDQsRR-----SRRQS 154
XP_018191110 147 -RNELRSYAN-----CFDQ-VR-----DCRRR 166
XP_018287905  99 ---P-PT--------YFNLkPQkn-tlDTHRP 117
OAC98601     116 -KRN---NDTFAAasYFHPkPRk---vSSSIP 140
GAN02510     119 -NNDt--YAAASY--FHPK-PRkvssiPFMEQ 144
KXS13076     196 lSQSs--MSTSTS--SSAK-LRa----KMPVP 218
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