Conserved Protein Domain Family
TBD
?
pfam12845: TBD (This model is not part of the current CDD release)
TBD domain
The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, has been found to be essential for poly(I:C)-induced IRF activation. The domain is found in SINTBAD, TANK and NAP1 protein. This domain is predicted to form an a-helix with residues essential for kinase binding clustering on one side.
Links
?
Statistics
?
PSSM-Id: 520488
Aligned: 10 rows
Threshold Bit Score: 67.0985
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_005993775 215 QKSEEFLQRAYWELKKEMSNLHLVTKVQSEVLRKLRAtLTAANKDSLSFPAQCVED 270
XP_002749442 132 LHERDNIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTATETQCSVPIQCTDK 186
XP_542751    214 SISSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKIpTTIK---KACSPVGCMED 266
XP_008119738 227 DIHSVNVQHAYWELKKEMSNLHLVTEVQAEMLKKLKLiPLGTRKVPSCTPLQCVED 282
XP_015214543 136 DDKSKEILEAFQEIQGKFHVIQNLTRKQKDHLNKLCRaNDTAQEQQFSMPIQCTDV 191
XP_056649928 155 FNKREEIEKTFYEMKEEFHRICMLARAQREHLNRLNI-QEPIPEIQFSMPIQCTDE 209
XP_001511169 193 SHERADLEKTFLEMKEELHRICMLTRMQTDHLSKFNLkNETAREIQFSMPIQCTDK 248
XP_046799566 190 lpeRENLETIFQEMKEECHRICMLAREQTDQLSKFKIkPEPETEIQFSMPIQCTDK 245 chicken
XP_063124567   8 GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQeQARNAG-QRHSPLSQRHS 62  Norway rat
XP_057357390 286 GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQeQARSGG-QRHSPLSQRHS 340 Chinese pangolin
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap