4CV5


Conserved Protein Domain Family
DUF3819
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pfam12842: DUF3819 (This model is not part of the current CDD release)
CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819
This is an uncharacterised domain that is found on the CCR4-Not complex component Not1. Not1 is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID.
Links
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Statistics
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PSSM-Id: 520487
Aligned: 112 rows
Threshold Bit Score: 84.8685
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4CV5_A         17 DLKRVFQMALAKSVREILL-EV-------VEKSSGIAVVTTTKIILKDFATEVDESKLKTAAIIMVRHLAQSLARATSIE 88   brewer's yeast
XP_004989136 1411 NLNSLVVNTFQACLAEVVV-SA-------RTRATNVAVTTAHRTLAKDFVYERDIKLFRTTALAMAQKFASNLAATIGRD 1482
Q38C90       1216 vYKGYLAKTLERVTQE-LK-PT-------VQRSGTIAAVTACHITTKDFLFDRDIKAQLRAADAMARSLASNLCTVAIRD 1286 Trypanosoma b...
XP_001564795 1179 dhrleIVAQLQAVVDEAVS-YC-------MQRSVAIAARTTEQLVLKDYARDPFPDDMLVAGDAMARSLASSLSYVMVRD 1250
XP_001321421 1033 pdnseiplSLKEKIKEVVVnYLvsflhkdGPLLADKAANTTLELVRKDFKNAQAPEIMLEPAHQMVHQLSNSLTLFNAIY 1112
2_pfamImport    2 TLKTYVRNAIERSIQEWIN-PV-------VERSVKIAVITTEHIVKKDFGMDPDDTHLRKAAHCMVRNLTSGLAMITCRE 73  
3_pfamImport    2 ALKNYVQAVIERSIQDWLN-PV-------VDRSVKVAATTTENIVKKDFGMDPDESHLRKAAHCMVRNLTSGLAMITCRE 73  
XP_002111977 1264 HLKSYVKVAIERAVQELLL-PV-------AERSIKIVINTVEKLIKKDFALDPDETHLKTGSHNMLRYFTAGMALITCRE 1335
XP_009018098 1297 QLKQYVRPAIERAVQELLS-PA-------IERAITIALKTSEIIVKKDFALDPDENRLRTAAHSFVRFMTGGMALITCHE 1368
NP_001333557 1300 HAKHLVRPAMIHAIKELIG-PV-------TERALKIAMTVTESLVRKDFALDPEEQNLRAASFHMMRAMTAGMAMITCRD 1371 Caenorhabditi...

4CV5_A         89 PLKEGIRSTMQSLAPNL-------MSLSSSP---AEELDTAINENIGIALVLIEKASMDKSTQDLADQLMQAIAIRRYHK 158  brewer's yeast
XP_004989136 1483 SLKTSFVRKLKEQFGESm-----rLSSQQEK---DTVLGKLADENMGLATAFLKMSCMGSVEPMLDDRFYEDYEIRRKQg 1554
Q38C90       1287 ALPEPFNVQVGDLISRLi-----dVNVPSYTerrERLKGLIRENNMDLCVRALEWQAAEEGAKRLHEKLDKIIKEKidqi 1361 Trypanosoma b...
XP_001564795 1251 ELPLLLHRSMTNLLERIl-----aPYTPLEHk--ATIRDTLVARNLELCMRAVEYSVGEEAATATSRFLFDVVREKASaf 1323
XP_001321421 1113 KLPANLVKKLHSVISTPd----------------NDWIDEIAAKNYEWIAQVLRDSVAIRSWNTVKTILMKEIEEERQHR 1176
2_pfamImport   74 QVIQTLTTNLKQHFMSVlis--psQSQKEMI---DQACTMCANDNLELACAFVQKTATEKAVIEIDKYLKIEYERRSMSR 148 
3_pfamImport   74 QVVQLLTSNLKQHFLSVlmt--ptPSQKEMI---DQACTMCANDNLELACAFVQKTATEKAVIEIDKYLKTEFERRNVSR 148 
XP_002111977 1336 ALHMAISNNLKSAFMSNlr---ntSNMKDII---EEAATIIANENTEHACAFVQKSAVDKALLEINKALAAEFEIRKHAR 1409
XP_009018098 1369 PILISISNNLKTMLSAAlrv--psAQQKELI---DHASQIIAQDNAELATVFLQKTAIDRAIPEIDKRLASDYEARRVAR 1443
NP_001333557 1372 PLASSMHSNLANAFSSSlrstaanPEMKQMI---EDAAATITQDNVELSTNFIVKTACEKATQDIEKRLEADYQKRIAAK 1448 Caenorhabditi...
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