8QX8


Conserved Protein Domain Family
TPR_Vps8
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pfam12816: TPR_Vps8 (This model is not part of the current CDD release)
Vps8 central TPR
Vps8 is one of the Golgi complex components necessary for vacuolar sorting. Eukaryotic cells contain a highly dynamic endo-membrane system, in which individual organelles keep their identity despite continuous vesicle generation and fusion. Vesicles that bud from a donor membrane are targeted and delivered to each individual organelle, where they release their cargo after fusion with the acceptor membrane. Vps8 is the core component of the endosomal tethering complex CORVET (class C core vacuole/endosome tethering). Vps8 co-operates with Vps21-GTP to mediate endosomal clustering in a reaction that is dependent on Vps3. Vps8 is the only CORVET subunit that is enriched on late endosomes, suggesting that it is a marker for the maturation of late endosomes. Late endosomes form intralumenal vesicles, and the resulting multivesicular bodies fuse with the vacuole to release their cargoes. Vps8 consists of a beta-propeller at the N-terminal (pfam23410), a central TPR-like region and a RING finger at the C-terminal. This entry represents a central TPR segment after the beta-propeller.
Links
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Statistics
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PSSM-Id: 520471
Aligned: 351 rows
Threshold Bit Score: 76.7812
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8QX8_F          538 VYFEVVANIVAQGSVTS------I-S-PVLFRSIIDYYAKEE-NLKVIEDLIIMLNPT------TLDVDLAVKLCQKYNL 602  brewer's yeast
37_pfamImport     1 VFFEQLEPYILGDKFVGg----iK-N-ATIAQGLLNFYTKHG-LYKRLEECLLHMHPA------VLNIDEILNICEDQKL 67  
70_pfamImport     1 IFFETLEIYILNHKIDKlytednL-N-PSISEAFINYFYEKK-WYSRLEECIILIDPQ------LLNIDNLIKIFRDKKL 71  
77_pfamImport     1 IFFETLEIYILNHKIDKlyaednL-N-PSISEAFINYFYEKK-WYSRLEECIILIDPL------LLNIDHIIKIFRDKKL 71  
74_pfamImport     1 IFFETLEIYILNHKIDKlytednL-N-PTISDGFINYFYEKK-WYSRLEECIILIDPT------LLNIDHIIKIFRDKKL 71  
71_pfamImport     1 IFFDTLEIYILNHKINKlyaennL-N-PSISEAFINYFYEKK-LYSRLEECIILIDPN------LLNIDHIIKIFRDKKL 71  
62_pfamImport     1 IFVESLESFVLSGRVHV------IfN-PTVIQVLISHYLSQS-WLDRLEQIILHLDPT------TLDIHQILLLCEQHGL 66  
RKO87519        490 VFYETFEHAVAKGEVQA------V-EnPALVRNLVDVYCRRG-WIERAEAVLMSVELD------GVDLDGILGLCRRYGM 555 
126_pfamImport    1 VYFETLEEYAIREELTN------I-SnPTVVSAFIAYYKKQG-WFARAEQVILQLDPA------SIDVHGILTLCRSTGL 66  
61_pfamImport     1 IFLEVLEPFIENGIIKS------V-S-PMVLQSLVKSYSEDElKRKKLEECLLYINLSpnsdgiEIDVDGLLSTCSMWKM 72  

8QX8_F          603 FDLLIYIWNKIFDDYQTPVVDLIYRI------------------------------------------------------ 628  brewer's yeast
37_pfamImport    68 YVASTYVYTQGLNDFTSPLMQLLKPMgd---------------------------------------------------- 95  
70_pfamImport    72 YKGLIYIYSHVLKDFISPIIDILMDLieekeinqsekyddlnqmmnvdtnnnfvklktrsendidyik----tnlklqns 147 
77_pfamImport    72 YKGLIYIYSHVLKDFISPIIEILMDLmegkeknriikdsnnnqvlndskntgnyiklktrsennvddi---knssklpnd 148 
74_pfamImport    72 FKGLIYIYSHVLKDSISPIIEILMDIikikennlivnndnqqdindsqyninfiklktrsennvddikhelnsqnnltnn 151 
71_pfamImport    72 FKGLIYIYSHVLKDYISPIIEILMDLmevkennyiskedsnsnmdnpqsnvnyiklktrsesnvdyikn-glkknnnykd 150 
62_pfamImport    67 HNALVYVYNKTLKDYITPLVLLMGLVnisengnd---------------------------------------------- 100 
RKO87519        556 VGALCCVCNRAAGDYVLPVVEMLLAIqrgpr------------------------------------------------- 586 
126_pfamImport   67 YNAVIFIYNRALRDYVSPIVEILKLMatddqidigkr------------------------------------------- 103 
61_pfamImport    73 WKALFRIWIDILHDPTKPASDMFIYLdsfinefs---------------------------------------------- 106 

8QX8_F          629 ---------------------------------SNQSEKCVIFNGPQVPPETTIFDYVTYILTGRQYPQNLS-IsPSDKC 674  brewer's yeast
37_pfamImport    96 ---------------------------------mLELSPQLVLPQNGDDHAYLAYVYLSFILSGRNFPNGDS-M-GPQS- 139 
70_pfamImport   148 kdnlrsksegdvnkkskeksvkiidtfinkdneEEVTNIKKIYNKKKNDVEYMLYVFLAYSLSGKSFPFGLP---NLDNA 224 
77_pfamImport   149 kdklraksesdinkkpkeknvtivdtlidndneEEMSNTKKIYNKKKKDVEYMLYVFIAYSLSGKSFPFGLP---NMENA 225 
74_pfamImport   152 lkpksegdinkknksreksltiidslienneedKNANYTKKIYNKKKKDIEYMLYVFIAYSLSGKSFP--FGlP-NKDNP 228 
71_pfamImport   151 nvrtksesdinkkpnpkeknvkiidgftndneeGVNTTTKKIYNKKKKDVEYMLYVFIAYSLSGKTFP--FGlP-NEENS 227 
62_pfamImport   101 --------------------------vsssldqSMDTPSQLDKSLKRQSGIYTIYVYLAYALTGQAFPMG-S-L-EPDQA 151 
RKO87519        587 ----------------------------srdqlVDDGGVSTREDTRNDSGVYTLFVYLAYVLTGKAFPFGT--L-SPNEA 635 
126_pfamImport  104 ----------------------lmnrsihhdevEELSEMKRCTESARRDSIYALYVYLAYILTGKAFP--VGaL-PVKEA 158 
61_pfamImport   107 --------------------------lsnspdsLMD-DSWTSKFHVLSYETSVLFPVLENVLCGLSYPTGVPfS-SNSQA 158 

8QX8_F          675 SKIQRELSAFIFSGFSIKWPSNSNhK-------------LYICENPEEEPA----------------------------- 712  brewer's yeast
37_pfamImport   140 LAAKREIYSILFSKDKKS----ES---------------LGQSSKWYNSVP----------------------------- 171 
70_pfamImport   225 KEAKIQCYNFLFSKNYIKWQYKKE----------------FKE-IIIGISP----------------------------- 258 
77_pfamImport   226 KEAKIQCYNFLFSKNYIKWQHRKE----------------FKD-IIIGTSP----------------------------- 259 
74_pfamImport   229 KEAKIQCYNFLFSKNYIKWQYRKE----------------FKD-IVIGSTP----------------------------- 262 
71_pfamImport   228 KEAKIQCYNFLFSRDYIKWQYKKE----------------FKD-IVIGNTP----------------------------- 261 
62_pfamImport   152 LKIKSDLYSFLLSPVQIDHPGTNS--------------------LNLGVTP----------------------------- 182 
RKO87519        636 AQARSDVLSFLFSRARATWPPSRT---------------GTAAPVAAGDEP----------------------------- 671 
126_pfamImport  159 LKAKTDVYNFLFSPYHAFWPPDGM-S-------------AETSLLRLGDPP----------------------------- 195 
61_pfamImport   159 VSMASSTLSFLTNPLHPETPNTNI-YsvfypgkainyniNS-NSNSNS--Nssvsvafeapfspnnpcsinggdlnntsi 234 

8QX8_F          713 -----FPYFHLLLKSNPSRFLAMLNEVF 735  brewer's yeast
37_pfamImport   172 -----FPYLYLLIKYDAGQFFAMLATVF 194 
70_pfamImport   259 -----YPYLKELFKRNTAEMLKVLGAAF 281 
77_pfamImport   260 -----YPYLKELLKRNTTEMLKVLGAAF 282 
74_pfamImport   263 -----YPYLKELLKRNTNEMLKVLGAAF 285 
71_pfamImport   262 -----YPYLKELLKRNTSEMLKVLGAAF 284 
62_pfamImport   183 -----FPYLRLLVIADVDELTKMLGSIF 205 
RKO87519        672 -----FPYIRTLLACDVREFLKVVGSAF 694 
126_pfamImport  196 -----FPYVRLLFRHDPKEFLKVIGQAF 218 
61_pfamImport   235 ysksnYKYLEILLTVNTKKTLSIFNAVF 262
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