Conserved Protein Domain Family
CTD

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pfam12815: CTD 
Spt5 C-terminal nonapeptide repeat binding Spt4
The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe. The repeat has a characteriztic TPA motif.
Statistics
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PSSM-Id: 372327
Aligned: 26 rows
Threshold Bit Score: 42.4325
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002794644         875 SSRTPAWNAaaASSSRTPAWKADGSRTsnpydgnrTAYGGGaf---sGSRTPAW-TAG-TKTPYDSssgfgvssnsgfda 949 
Q2GQE5               784 GSRTPMGAG---GGERTPAWG--------------APKGEFyllpcvQGLNANY-------TPAHDg------------- 826  Chaeto...
CAP26184             815 GSKTPMY------GAQTPMYGAM------------TPHA--------GDRTPHY---S-AMTPAYD-------------- 850 
EDO32246             131 IYRTPAFHT----IYRTPAFHTIYCT---------PAFHT-------IYRTPAF-HTI-YRTPAFHtiyr-------tpa 181 
XP_001581848         628 EEETPAVEE--KKKEETPAVEEKKEET--------PAVEEK------KEETPVEeKKE-EETPAQE-------------- 676 
EDO34043              27 SDLTPIYYQ---QSDLTPLYYQQSDLT--------PLYYQQ------SDLTPLYyQQS-DLTPLYY-------------- 74  
EDO43567             136 DSQTPHYCD---LDSQTPHYWDLDSQT--------PHYCDL------DSQTPHYcDLD-SQTPHYC-------------- 183 
WGS:AAPP:GF12341-PA  814 GAQTPSYTA---AGSKTPLV---GSQT--------PNWDT-------DTRTP-Y---G-TMTPSHD-------------- 853 
EEC08092             678 GSQTPMYSS----GSRTPMY---GSQT--------PLYEA-------GSRTPHF---GgGQTPVHD-------------- 718 
P0CR70               853 GGKTPSAAN--ASGGKTPAWGASGGKT--------PAYGMAs-----GGKTPAYgMQG-GKTPNAYama---------pp 907  Crypto...
XP_002794644         950 fAAGSRTPAY----PGGT---------------------GSRTPAWGP 972 
Q2GQE5               827 fGHGSKTPAYgagnNDPW---------------------GSKTPAYGV 853  Chaetomium globosum CBS 148.51
CAP26184             851 ---GGRTPAY----GD-----------------------GGRTPAYGS 868 
EDO32246             182 fHTIYRTPAF----YTIYrtpafhtiy---rtpafslhtIYRTPAFHT 222 
XP_001581848         677 --KKEETPATe---EKKEeespvaeekkeeetpvaeekkEEETPAVEE 719 
EDO34043              75 -QQSDLTPIY----YQQSd----------------------lTPIYYQ 95  
EDO43567             184 -DLDSQTPHY----CDL----------------------DSQTPHYCD 204 
WGS:AAPP:GF12341-PA  854 ---GSMTPRH-----GAWdptanttpar-nnefdysleePSPSPGYNP 892 
EEC08092             719 ---GSRTPVH-----GAWdpttantpa---rpelddyqlEEASPSYQP 755 
P0CR70               908 gPSGGRTPAY-----GAYgrpeasg--------srpsvmAPPSAPYSA 942  Cryptococcus neoformans var. neoforman...
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