Conserved Protein Domain Family
eIF3_p135

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pfam12807: eIF3_p135 (This model is not part of the current CDD release)
Translation initiation factor eIF3 subunit 135
Translation initiation factor eIF3 is a multi-subunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. The protein product from TIF31 genes in yeast is p135 which associates with the eIF3 but does not seem to be necessary for protein translation initiation.
Statistics
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PSSM-Id: 520466
Aligned: 128 rows
Threshold Bit Score: 104.98
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002550200   718 QAIPFEGKQLTETLHRSGINMRYLGFIAdkiisrreqflaeteelikaneaaaekkqkeeeekakqeaekakedtekgek 797 
XP_002172984   679 SAMPVDGIALARMMHKRGINMRYLGKVAela------------------------------------------------- 709 
XP_013025517   706 SFMPIDGIALSRALHRNGINIRYLGDML---------------------------------------------------- 733 
O59742         704 SFLPIDGVALCRAMHRSGINIRYLGEIA---------------------------------------------------- 731  Schizosaccha...
XP_002290850  1052 FELPVDGKSLTELIHQRGINCRYLGRLAelakqkene------------------------------------------- 1088
6_pfamImport     1 SLCPLDCAELAKVLHGSGVNMRYLGRLAtvaiee---------------------------------------------- 34  
19_pfamImport    1 AIAPADGYALTQLMHSCGINMRYLGRLAsl-------------------------------------------------- 30  
XP_002895256   805 AIAPADGYALTQLMHSCGINMRYLGRLAsl-------------------------------------------------- 834 
XP_067744282   809 ASAPADGYSLTQLMHSCGINMRYLGRLAll-------------------------------------------------- 838 
XP_004039976   753 NSRLADSLSVSDCFHLNGVNIRYLGKVIns-------------------------------------------------- 782 
XP_002550200   798 keddkevkseeeeeeetptkatYQLSLASYSTLY------RVVVQEMIARASKHVLRDLTKN---VSDYLIPYVVAHFHN 868 
XP_002172984   710 --------------------asQYGNDHPLVYLA------EL---EMLARAVKHVFSNNIAK---HSFYNRASSVAYLLC 757 
XP_013025517   734 --------------------------YVILDKYPentamiRLFTSEIFARSAKHLIRAYISK---TPRCLISHVVSHFFN 784 
O59742         732 --------------------------NIILQKSPnnvillKLVTSEIFIRSIKHVFRNFLAV---VPQVLRSHLLSHLLN 782  Schizosaccha...
XP_002290850  1089 -------------deeaekayeKNKREAKLPRHRmpltwlELLECEIVARAAKHVLDSYFLEqggVAAAHPAQTVASFLS 1155
6_pfamImport    35 -----------------eaedaAVRADGKLRRWRmplfwlEMLETEMVARAATHVFNRYMAMsspRARHAQGRAVQQFLN 97  
19_pfamImport   31 --------------------akKLEAIGGISKYMl-----EMLEVEMISRVAKHVLADVFNSd-nSIRAAPGSAIVNLLN 84  
XP_002895256   835 --------------------akKLEAISGISKYLl-----EILEVEMIARVAKHILADVLNSn-dSIRAAPGTAIVKLLN 888 
XP_067744282   839 --------------------akKLEAIGGISKYFl-----EVLEVEMISRVAKHILADVLNSn-dSIRAAPGSAIVKLLN 892 
XP_004039976   783 --------------------lnQNDYPHIL----------MILQKTLLVKCLKHVLREIMRL---SVQNEIPYSISNALN 829 
XP_002550200   869 CLLGGDINQTpsvdip----------------hknfysESEL------------------------EFTKLEHKDILQLL 908 
XP_002172984   758 CIFSEdeafkdspv---------------ykeylqkipSESFq----------------------------TPTQVKESV 794 
XP_013025517   785 CLLAESEDDQsfpflpeesi-------------------------------------sqfypetcqMLVSMSPKLVSEAL 827 
O59742         783 NLFTVYGYVEptkplineni-------------------------------------anlffqatqVIYSINSTSLYSSI 825  Schizosaccha...
XP_002290850  1156 AVLSTGEESAsetdirlelggdidvddi--------------------------nalamseidangtgpirGRSDIWSDI 1209
6_pfamImport    98 CLIGGTENASpptapgcrrmtsa------------------------------------------------------ssr 123 
19_pfamImport   85 GILGSISRKMnsldtrvng-------------------------------------------datvatalsDSMTLWTRI 121 
XP_002895256   889 GILGSSSAAVsekadetc-------------------------------------------stdattttSLDSKTLWTRI 925 
XP_067744282   893 GILGSTSAVAdkkdvfet------------------------------------------ddaaatttASLDANTLWSRI 930 
XP_004039976   830 CIFSVSDIRDrlekgeicqqknntnnenmgggeknkqgKKNKkqhsnkqqkiqvlnksncivlpqwEVSKLKPSQIWEKV 909 
XP_002550200   909 SQQVFIRFRFTL---------------PENWISe-------SVS--LPALFREIAVKYGIQWKSSHYVF 953 
XP_002172984   795 AQNVASRFRYRIh-------------nSAKFVK-------------SPPLLRNICLKLGIQLLCRDYFC 837 
XP_013025517   828 MKESQSRFGYKI---------------PREFVK--------EVN--QISLIRLICLKLGIQLACKDYVS 871 
O59742         826 KKEASSRFRFNL---------------TDDLLH--------SLN--PICILRGTCLRLGIQISCKDYFS 869  Schizosaccharomyces pom...
XP_002290850  1210 EKEIGRRFRYTLslyn---------------------tddgKSRalYTPLLRRICQRSGIRIVTKKYKL 1257
6_pfamImport   124 spptgcgnpcALkcssgsatgwssggrPSNAEN--------AERrhKLPLLRRLSQRLGARVLSKTYRL 184 
19_pfamImport  122 GKEIKTRFDYELal-----------wgPGNNESggddiafpAGRvnKMVMLRRLCQRLGLRVESRNYNF 179 
XP_002895256   926 DMEIKARFDYKLtl-----------wgPGRDESrgenavylVGRvsKSVMLRRLCQRLGLRVVSRNYEF 983 
XP_067744282   931 DKEIKARFDYKLal-----------wgPGRGEAsaddatfpVGRahRIVLLRRLCQRLGLRVVSRNYDF 988 
XP_004039976   910 LNLAKKRYGYDGfp-----------enMSNLNLl-------NLKfnKLSILRDLLRTIGVQILYKDYYF 960 
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