Conserved Protein Domain Family
LRR_4

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pfam12799: LRR_4 (This model is not part of the current CDD release)
Leucine Rich repeats (2 copies)
Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Statistics
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PSSM-Id: 520460
Aligned: 225 rows
Threshold Bit Score: 24.8628
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001961349  286 DTLRSLNLM--EN-GIE-EIKLp--dCDplaklNiFMSLEQLNLs--H-NPIW--NEA--DAFNE 337 
A0BPX3         67 INLKVVHAS--DC-NLQ-DQNIendfFE-------LDSLKEFNMtknQ-------LSIidR-FTS 112  Paramecium tetraurelia
Q4Q6A2        306 CFLRSVHLS--GC-NVK-DADV----PHl----AqLPCVEEL-Ll--S-RTRI--TNV--QALAA 350  Leishmania major
A0BHX4        110 INLQKVYLSy-N--MLI-T--L----PHfl--eS-LTFLEVLDL---SyN------QI--QIYNV 150  Paramecium tetraurelia
XP_002502128  217 GTLQHLRLS--RN-WFA-AVPP----EV-----KeLWALRELDMsrnF-V-RNteDALplAALAK 266 
XP_001565316  149 TRLRRLYLQ--GN-RIGsLNGL----PP-------LRHLRELWL---S-RNRL--SAL--THLTS 191 
Q60ER5        444 RNLTRLHLQd-N--KLN-GTVP----QTl---gI-ITSLRELFL---Q-N--N---EL--DGAVP 485  Japanese rice
XP_002178211 1014 TQLRVLRIDr-N---ML--GSL----PSi----FqMVSLVEL-Ta-aR-N------KL--TTLPA 1053
O81765        300 SNVTVFDASknS--FIG-R--L----PTsf--vG-LTSVEEIDI---SgN--K---LT--GLVPH 342  thale cress
Q4QJ80        346 RALKKVDVS--GCaALR-DAAA----LT-----H-LSQLTHVDL-----S-FTavDDV--SSLAY 389  Leishmania major
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