Conserved Protein Domain Family
VESA1_N

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pfam12785: VESA1_N (This model is not part of the current CDD release)
Variant erythrocyte surface antigen-1
This family represents the N-terminal of the variant erythrocyte surface antigen 1, versions a and b, of Babesia. Babesia bovis is a tick-borne, intra-erythrocytic, protozoal parasite of cattle that shares many lifestyle parallels with the most virulent of the human malarial parasites, Plasmodium falciparum. Babesia uses antigenic variation to establish consistent infections of long duration. The two variants of VESA1, a and b, are expressed from different but closely related genes, and variation is achieved through the involvement of a segmental gene conversion mechanism and low-frequency epigenetic in situ switching of transcriptional activity from the VESA1 gene-pair to a possible other gene pair.
Statistics
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PSSM-Id: 520450
Aligned: 4 rows
Threshold Bit Score: 753.708
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001609533   13 AAVTDLLQSVQLEYH-------------GYQGEAK---------DKGPQKERVEGCLNEVFSLVQGLGGTAVVRTYIDQL 70  
XP_001609034   34 AAVTDLLQSVQLEYHvph-------galGYDGDTK---------DAGATYEQVKEHLNGLFSLVQGLGGTAVVRTYIDQL 97  
XP_001609040   48 AAVTDLLQSVELEYH-------------GYQGDVKngaegdsktTKGASADTVKGHLNGLFSLVQGLGGTAVVRTYIDQL 114 
XP_051623576   50 AAVTDLLQSVQLEYHvpllvystswcpiGYQGDVKdsa----ttNKGATKDEVTNHLNGLFSLVQGLGGAAVVRTYIDQL 125  Babesia bovis...
XP_001609533   71 AQVLSALVGWSKIDKCWQ------RHGGNNNN----QHGNEPnCGYLTDVKANTP-CKDCQCMKWSVTRPESE--GTPLG 137 
XP_001609034   98 AQVLSALVGWSKIEQCWNg----tCKKDGSNDlngsPHGDSS-CKYLQEVKENTP-CKDCRCMKWKVPGANDHskGHHLG 171 
XP_001609040  115 AQVLSALVGWSRIVKCDGng---eCNGN--------PHGKGK-CEYLKDLTPNDMsCGKCGCLKVGAE-------NHHLG 175 
XP_051623576  126 AQVLSALVGWSKIEKCWGsgssdkCKGTNGKGn---QHGKNE-CEYLKDIEAKNK-CDKCECMKWDVAKADDEknGHHLG 200  Babesia bovis...
XP_001609533  138 RKCTRCSDSSGSD-------ACNCSPgggDSCTA-EKCKCALAGKCCKCCCKSCNGCKENAKCSCMMD------DSYHCR 203 
XP_001609034  172 RGCTRCKDSGSSDa------GCKCTSg-gGGCSSgQECQCAKAGKCCKCCCTSCSGCKTNAKCSCTTEesithsRTTYGE 244 
XP_001609040  176 RGCDKCDGDKCGKpgagggcQCQCKGg-aSGCTSaSDCKCDR-----KCGCT---------------------------- 221 
XP_051623576  201 RGCKKCASDEEAKk------ACECGT---GGCSAgEECKCAKEGKCCKCCCTSCDGCKENAKCSCIENg----kNSLRIR 267  Babesia bovis...
XP_001609533  204 IYKDTYQSAYisytsnkhfekygmaATwNALhkF-TANfgsiRGNPTEKRSKCARILLGSVCLIWSGLTYMYWTGKYHSS 282 
XP_001609034  245 ITIERYMSSY---------------SN-NNHdnPpKWK----DASNTPNRHHCAKILLGSVCLIWSGVTYMHWTGKWASG 304 
XP_001609040  222 --IDTYRSAYrgryss---esyvgeTI-TAYreC-MWN----SPTNTTSRHQCARILLGSVCLIWSGLTYMYWTGKWHGT 290 
XP_051623576  268 EHKDSYRSAYevelvy---ewnigkEY-LVW--P-KWS----DRKTSKKRAVAARNLLGSVCLIWSGITYMYWTGKYHKS 336  Babesia bovis...
XP_001609533  283 SPRWNNHILDGTGLDDGTLSQWLQALGFPKAMLNDAGPGNRLDAVIWDGFRGMLYLGFP-DTGSgsg---hgWDTEGNTF 358 
XP_001609034  305 SPYWNNHILDGSGLDDGTLSQWLQALGFPRDMLNNSGPQNRLDKVIWDGFMGKLFLGFThPSGS--------HASDGNTA 376 
XP_001609040  291 SPRWNNHILDGSGLDDGTLSQWLQALGFPKDMLNNSGPQNRLDKVIWDGLRDKFLLGFLePSGLdsg---svSDTNGNTA 367 
XP_051623576  337 SPRWNNHILNGSGLDDGTLSQWLQALGFPKDMLNNHGPQNRLDKVIWDGIMDKLYLGFP-DTGKwsaervhgNDTDANTF 415  Babesia bovis...
XP_001609533  359 RDPSSMNYAGYIHTLEKGAFCSN-GNVFPKNANGAt----iTEEQMHKCGALFKLYILSCAYFTGLQNK---APPKAGNT 430 
XP_001609034  377 KQPYDMNYAGFVHTAHRDSFNKE-ATVFPKDGTGSsttghiGETNQNKIGAIFKLYVLSCAYFTGLQKRn-sTALSTTPT 454 
XP_001609040  368 RSPYGMNYPGFIHTAHRDSFNTDaATVFTNGSSTTnr---iSDTDQNKNGALFKLYILSCAYFTGLQKKnseSTTGTTAN 444 
XP_051623576  416 RQPAGMNYAGYIHTVDRGAFCKD-GTVFKNGSSST------SEENTNKCGALFKLYILSCAYFTGLQNK---APPKAENK 485  Babesia bovis...
XP_001609533  431 ---TPKTIREILYWLSALPYSPAYPEILKHGKDRL 462 
XP_001609034  455 atnNPKTIREILYWLSALPYSPAYPKILTHSKGRL 489 
XP_001609040  445 ---NPKTIREILYWLSALPYSPAYKEMLDYAKRRL 476 
XP_051623576  486 ---TPKTIREILYWLSALPYSQAYKQILEHSKEVL 517  Babesia bovis T2Bo
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