Conserved Protein Domain Family
VESA1_N

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pfam12785: VESA1_N 
Variant erythrocyte surface antigen-1
This family represents the N-terminal of the variant erythrocyte surface antigen 1, versions a and b, of Babesia. Babesia bovis is a tick-borne, intra-erythrocytic, protozoal parasite of cattle that shares many lifestyle parallels with the most virulent of the human malarial parasites, Plasmodium falciparum. Babesia uses antigenic variation to establish consistent infections of long duration. The two variants of VESA1, a and b, are expressed from different but closely related genes, and variation is achieved through the involvement of a segmental gene conversion mechanism and low-frequency epigenetic in situ switching of transcriptional activity from the VESA1 gene-pair to a possible other gene pair.
Statistics
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PSSM-Id: 372315
View PSSM: pfam12785
Aligned: 40 rows
Threshold Bit Score: 629.737
Threshold Setting Gi: 156084546
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001609756   50 AAVTDLLQSVELEYHgkysvvhqlitvpGYEGDGN------ANGGATDADKTpqQHINDLFSLVQGLGGTAVVRTYIDQL 123  Babesia bovis...
XP_001611367   20 AAVTDLLQSVQLEYH-------------G-EG----------NNGPPKKRVT--ECLNELFSLVQGLGGTSVVRTYIDQL 73   Babesia bovis...
EDO08746       50 AAVTDLLQSVQLEYH-------------GYQGDVKds--atTNKGATKDEVT--NHLNGLFSLVQGLGGAAVVRTYIDQL 112  Babesia bovis
XP_001609540   47 AAVTDLLQSVQLEYN-------------GYQGDTKev---dTSKGASEQQVT--DRLNGLFSLVQGLGGTAVVRTYIDQL 108  Babesia bovis...
XP_001609101   48 AAVTDLLQSVELQYH-------------GYQGDSNg----sGKGGPPKKRVT--ECLNGLFSLVQGLGGTAVVRTYIDQL 108  Babesia bovis...
EDO06183        9 SAVTDLLQSVELEYH-------------GYQGEAKqad-ssQNKGATDKQVT--NHLNGLFSLVQGLGGTAVVRTYIDQL 72   Babesia bovis
EDO05217       51 AAVTDLLQSVELEYN-------------GYQGDTNga---eKNKGANAETVK--GHLNGLFSLVQGLGGTAVVRTYIDQL 112  Babesia bovis
XP_001609754   49 AAVTDLLQSVQLEYN-------------GYQGDVKngtdsgDNKGATSDKVT--EHLNGLFSLVQGLGGTAVVRTYIDQL 113  Babesia bovis...
EDO08332       49 AAVTDLLQSVQLEYY-------------GYEGDTKetd-seQKKGPPKARVT--ECLNELFSLVQGLGGTAVVRTYVDQL 112  Babesia bovis
XP_001608619   51 AAVTDLLQSVELQYH-------------GYEGDRKe----sNGNGPPKKRVT--ECLNELFSLVQGLGGTAVVRTYIDQL 111  Babesia bovis...
XP_001609756  124 AQALSAIVGWSRIMKCQKydcntgtcqrgrgtghgkFK-CCCGNNGNHngglrcckgqngadggkcrngkvcdgsskgds 202  Babesia bovis...
XP_001611367   74 AQVLSALVGWSKIDKCGN----------------------CDSSKGN--------------------------------- 98   Babesia bovis...
EDO08746      113 AQVLSALVGWSKIEKCWGs----------------gSSdKCKGTNGKGn------------------------------- 145  Babesia bovis
XP_001609540  109 AQVLSALVGWSEIVKCWGs----------------gGDgSCKGGGTGN-------------------------------- 140  Babesia bovis...
XP_001609101  109 AQVLSALVGWSKIDKCWGs----------------gDSeKCKGGGSSN-------------------------------- 140  Babesia bovis...
EDO06183       73 AQVLSALVGWSKIVKCSNg-----------------GKdKCKGGGTGN-------------------------------- 103  Babesia bovis
EDO05217      113 AQVLSALVGWSRIKECSS-------------------G-MCGGKPHSG-------------------------------- 140  Babesia bovis
XP_001609754  114 AQVLSALVGWSKIVKCDK-------------------G-GCD-------------------------------------- 135  Babesia bovis...
EDO08332      113 AQVLSALVGWSKIETCWD---------------------GCGGSSNNN-------------------------------- 139  Babesia bovis
XP_001608619  112 AQVLSALVGWSRIEQCKNg-----------------GG-NCKSGYGSGhg------------------------------ 143  Babesia bovis...
XP_001609756  203 crvvcangccSHG-GTG---CKYLDDVKLENSCNDCQC-KIVAGK------GHHLAKGCTKCSSDDGkktkSCHCKS--- 268  Babesia bovis...
XP_001611367   99 ----------QHG-TNEk--CQYLQEVKENKPCDTCKCmKWVVPEagk-deAHYLGRRCTRCEGSGQp---PCKCSSssg 161  Babesia bovis...
EDO08746      146 ----------QHG-KNE---CEYLKDIEAKNKCDKCECmKWDVAKaddeknGHHLGRGCKKCASDEEak-kACECGT--- 207  Babesia bovis
XP_001609540  141 ----------EHG-QNGt--CEYLEDVKPNKPCEQCKCmKWKVKNpn--tdGTPLGRKCQRCSDSGDd--dTCSCSPpgg 203  Babesia bovis...
XP_001609101  141 ----------EHG-EKTg--CEYLQDVKHENKCDACGCmKWNVTNad--neGTPLGRKCTRCSDSGSsa-hRCSCNTggs 204  Babesia bovis...
EDO06183      104 ----------EHG-EKPd--CGYLTDVTANDPCKECGCmKWNDPDpns-neGHHLGRRCQRCSDSGGs---TCKCSGtsg 166  Babesia bovis
EDO05217      141 -----------GG-TD----CEYLEDVQKNTPCDKCGCmKWVVTHpd--reGTPLGRRCTRCSGDKK----ECKCDIggd 198  Babesia bovis
XP_001609754  136 -----------HG-KQGsenCEYLKDKTPENKCDSCGCmKWKVKDpn--neGTPLGRKCTRCSDSGGs--sTCKCS---- 195  Babesia bovis...
EDO08332      140 ----------QHGtKDG---CTYLQDVKHENKCGTCGCmKWDVAVadddknGHHLGRGCTRCSGSRD----GCKCSPggg 202  Babesia bovis
XP_001608619  144 ---------aPHG-QDG---CGYLVDIKPSNKCGTCGCmKWDVSEanqndkGHHLGRGCTRCKDNGGr--dACQCSTp-g 207  Babesia bovis...
XP_001609756  269 STCSP--ENCQCAKAGKCCKCCCT--SCsGTC---KE--KCICDKV----------------DPNGYRSAYPKTTGmwvE 323  Babesia bovis...
XP_001611367  162 SACQGp-DSCKCALAGKCCKCCCT--SC-GKC---SD--KCSCIEQeknil-------giyeHNESYVSAYKVKLV---H 222  Babesia bovis...
EDO08746      208 GGCSAg-EECKCAKEGKCCKCCCT--SC-DGC---KEnaKCSCIENgknsl-------rireHKDSYRSAYEVELV---Y 270  Babesia bovis
XP_001609540  204 GGCSP--GKCKCALAGKCCKCCCKg-RC--GC---KK--ECRCIEEdkdkvndt-ykrghriYNDSYQSAYGEM-----S 267  Babesia bovis...
XP_001609101  205 STCTA--ETCKCALAGKCCKCYCKgkGC--GC---KDa-KCSCDKEm--------------kDEDSYLSAYRKR-----N 257  Babesia bovis...
EDO06183      167 GACTGpgQECQCAKEGKCCKCCCNk-KC-GKC---KE--ECSCIIEdgivg-------sdecNRDSYMSAYPSDAIn-iR 231  Babesia bovis
EDO05217      199 ASCSAd-QECQCAKAGKCCKCCCKe-KC-GNC---KK--ECSCDKGsshv--------sdeyNKDSYMSAYPSRTVf-tR 261  Babesia bovis
XP_001609754  196 GTCSPg-QQCQCALAGKCCKCYCKe-DCkEKC---KKdaKCICDK-------------------DIYISAYPKT-----T 246  Babesia bovis...
EDO08332      203 SDCSTg-EECKCAKEGKCCKCCCNg-RC-GNC---KR--ECSCIIEdgvvg-------rdecNRDSYMSSYPSRTVf-mR 266  Babesia bovis
XP_001608619  208 SGCSAg-EECKCAKKGKCCKCCCNggQCsAGCageKA--KCICDKEkqqgkenggntydeeyRIHSYTSSYPHKPIl-iK 283  Babesia bovis...
XP_001609756  324 GGFTI---------TWVQLGDTTFds-ngAMPPSQRRQQCARILLGSVCLIWSGITYMYWTGRYAESSPRWNNHILDGTG 393  Babesia bovis...
XP_001611367  223 EGYFGreyq--vwpKWS------------DRKTSKKRAVAARNLLGSVCLIWSGLTYMYWTGKYAKGSPRWNNHILDGSG 288  Babesia bovis...
EDO08746      271 EWNIGkeyl--vwpKWS------------DRKTSKKRAVAARNLLGSVCLIWSGITYMYWTGKYHKSSPRWNNHILNGSG 336  Babesia bovis
XP_001609540  268 FPYIGeegyyliksVWTDLLERGG-----SMPPSQRRHHCAQTLLGSVCLIWSGITYMYWTGKYHKSSPRWNNHILDGSG 342  Babesia bovis...
XP_001609101  258 TSWVDggi----raTWLNLEEVPYsg--yPVTPSQRRHHCARILLGSVCLIWSGLTYMYWTGKYHKSSPRWNNHILDGSG 331  Babesia bovis...
EDO06183      232 KSFLEseri-dvktRWN------------NVTSSPNRHQCARIFLGSVCLIWSGLTYMYWTGKYHKSSPRWNNHILDGSG 298  Babesia bovis
EDO05217      262 QSFIHseri-daktRWN------------NVTSSPNRHHCARILLGSVCLIWSGLTYMYWTGKWAETSPRWNNHILDGSG 328  Babesia bovis
XP_001609754  247 GSWAEggy----tiTWAQLgdttf-dndgAVNPSQRRHQCAHILLGSVCLIWSGLTYMYWTGKYAETSPRWNNHILDGSG 321  Babesia bovis...
EDO08332      267 ESFTQskrv-dvkpYWKDLIDIPPgdnsyDTTASDRRHQCAQTLLGSVCLIWSGITYMYWTGKYHSSSPRWNNHILDGSG 345  Babesia bovis
XP_001608619  284 DSYVEskri-dvkpYWKDLINPRGf---yPGSASQRRHQCARIFLGSVCLIWSGLTYMYWTGKYHSSSPRWNNHILDGSG 359  Babesia bovis...
XP_001609756  394 LDDGSLSQWLQAVGFPHAMLNNSVPENRLDQVITDEFRDRFYLGFPdTSNS----AVHGRDNNANTFRSPANLTYGGFIH 469  Babesia bovis...
XP_001611367  289 LDDGTLSQWIQALGFPRDMLNNSGPQNRLDKVIWNGIMGKLYLGFP-NTGTggnvDIHGYDGDENTFRDPSSMNYAGYIH 367  Babesia bovis...
EDO08746      337 LDDGTLSQWLQALGFPKDMLNNHGPQNRLDKVIWDGIMDKLYLGFP-DTGKwsaeRVHGNDTDANTFRQPAGMNYAGYIH 415  Babesia bovis
XP_001609540  343 LDDGTLSQWLQALGFPRDMLNNHGPGNRWDAIIWDGFMGKLYLGFPhTSDN----AAHGSDHNDNTFRSPAGMNYAGYIH 418  Babesia bovis...
XP_001609101  332 LDDGTLSQWLQALGFPRKMLNNHGPRNRWDAVIWDGIRGMLYLGFPhTSYN----AAHGSDHDDNTFRQPAGMNYAGYIH 407  Babesia bovis...
EDO06183      299 LDDGTLSQWLQALGFPKEMLNNHGPGNRLDAVIWDGIRGMLYLGFPhTTDN----AAHGKDYNDNTFRQPAGMNYAGYIH 374  Babesia bovis
EDO05217      329 LDDGTLSQWLQALGFPQAMLNNHGPGNRLDEVINSDFVQKFFMGYAdTSNNs---GSHGQDKDDNTFRNPAGLNIGGFIH 405  Babesia bovis
XP_001609754  322 LDDGTLSQWLQALGFPREMLNNSGPGNRLDAVIWDGFKEKFYLGFPdTSSD----NGHGQDSWDNSFRNPAGMNFAGYIH 397  Babesia bovis...
EDO08332      346 LDDGTLSQWLQALGFPKAMMNDHGPGNRWDAIIWDGIMGKLYLGFP-NTGDwhnfAVHGHDNHANTFRQPAGMNYAGYIH 424  Babesia bovis
XP_001608619  360 LDDGTLSQWLQALGFPREMLNNNGPKNRLDKVIWDGIRDMLYLGFP-NTGIggnsAVHGIDDDANTFRNPAGMNYAGYIH 438  Babesia bovis...
XP_001609756  470 KINKGAFDKD-GPFKDYTE------AKIDNNKLGPILKLHILSCAYFTGLQKRRvlASTQSTTNTPKTIREILYWLSALP 542  Babesia bovis...
XP_001611367  368 TMDKGAFCSNaTIFHKNDTts---tTDENTNKCGALYKLYILSCAYFTGLQKK---TPPKGGNTNPKTIREILYWLSALP 441  Babesia bovis...
EDO08746      416 TVDRGAFCKDgTVFKNGSSs----tSEENTNKCGALFKLYILSCAYFTGLQNK---APPKAENKTPKTIREILYWLSALP 488  Babesia bovis
XP_001609540  419 TVDRGAFDSD--VFKENG-------KDINKNKLGAIFKLYILSCAYFTGLQKK---NTTESTPRTPKTIREILYWLSALP 486  Babesia bovis...
XP_001609101  408 TVDRGAFDSS--VFKGTGD------TKIDKNKQGALFKLYILSCAYFTGLQKKT--NTQTTTSTTPRTIREILYWLSALP 477  Babesia bovis...
EDO06183      375 TVDKGAFDSS--VFKGTG-------NGIDKNKLGALFKLYILSCAYFTGLQKKS--STQSSTSTTPRTIREILYWLSALP 443  Babesia bovis
EDO05217      406 AINKGAFGKTsNVFPKNGSsssstgTVPDQNKIGAIFKLYILSCAYFTGLQKK---TPPKADNRNPKTIREILYWLSALP 482  Babesia bovis
XP_001609754  398 TLEKGAFGDS--VFKADK-------SVPDQNKLGPLYKLYILSCAYFTGLQKK---TPPKADNKTPRTIREILYWLSALP 465  Babesia bovis...
EDO08332      425 TMDKGAFCSKaIVFNNGTTs----iTEENIHKCGALYKLYILSCAYFTGLQKK---GPPKAENKTPKTIREILYWLSALP 497  Babesia bovis
XP_001608619  439 TVDRGAFCSNgNVFKKANDat---iTEENINKCGALYKLYIISCAYFTGLQNK---APPLAENRTPKTIREILYWLSALP 512  Babesia bovis...
XP_001609756  543 YSPAYKGLLNHCKEKL 558  Babesia bovis T2Bo
XP_001611367  442 YSPAYPMILEHSKEVL 457  Babesia bovis T2Bo
EDO08746      489 YSQAYKQILEHSKEVL 504  Babesia bovis
XP_001609540  487 YSPAYPEILQHSKEVM 502  Babesia bovis T2Bo
XP_001609101  478 YSPAYKDMLDYAKERL 493  Babesia bovis T2Bo
EDO06183      444 YSQAYKDMLDYAKERL 459  Babesia bovis
EDO05217      483 YSQAYPEILKHGKSAL 498  Babesia bovis
XP_001609754  466 YSQAYKQLLDYAKGRL 481  Babesia bovis T2Bo
EDO08332      498 YSPAYPKILTHSKGIL 513  Babesia bovis
XP_001608619  513 YSKAYPEILQHSKEVM 528  Babesia bovis T2Bo
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