8UCQ


Conserved Protein Domain Family
Sec7-like_HUS
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pfam12783: Sec7-like_HUS (This model is not part of the current CDD release)
Mon2/Sec7/BIG1-like, HUS domain
The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF. This is the HUS (homology upstream of Sec7) domain of Sec7 and related proteins such as protein Mon2 and BIG1-like proteins, which plays a regulatory role together with DCB domain (pfam16213).
Links
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Statistics
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PSSM-Id: 520449
Aligned: 208 rows
Threshold Bit Score: 74.465
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8UCQ_B         333 YIRDAYLVFRSFCNLs--TKIL-PPDqlyDLR---GQPMRSKLISLHLIHTLLNNHIT--VFtsplctirntknnEPTNF 404  Thermothiela...
5_pfamImport     1 GVRCVVDIFHFLCSLlnvVDIVeSEGf--SSQ---ASDQNIQIFGLVLINSAVELSGD--TIg------------KQPKL 61  
XP_002324976   250 GVRCAVDIFHFLCSLlnvVQVVeTEGs--TSH---AADEDVQLFSLVLINSCIELGGP--EIg------------KHPKL 310 
22_pfamImport    1 GIRSAVDIFHFLCSLlnvVEVMeTDGs--TSQ---TSDENVQLFALVLINSAIELSGD--SIg------------KHPKL 61  
XP_002281184   255 GVRSAVDIFSFLCSLlnvVEVVdMDGs--QVQ---TADEDVQLFALVLINSAIQLSGD--EIg------------KQPKL 315 
F4K2K3         238 GIRCCIDIFHFLCSLlnvVEVVeNLEg-tNVH---TADEDVQIFALVLINSAIELSGD--AIg------------QHPKL 299  thale cress
XP_001420107   327 glpaLIEIFRFATSLiapDTH---G----RGS-----EDANSLFGLKLVTIMIDANAE--YFr------------ANHAL 380 
XP_003055639   308 glMCVLEIFRFSVSFvslERD---A----DEN-----AEGACAFGLQLVLASLESSGD--HFa------------RHAPL 361 
XP_002947274   219 GVRAAMNILEFLIDLihkGPS---L-----QGatkETVEEMVVFSLDTIHSIICVAGSalVL--------------AEPL 276 
XP_003533383   256 GVRCAIDIFHFLCSLlnvVSIVeADGs--TSH---TADEDVQIFALVLINSAIELSGD--EIg------------KHPKL 316  soybean

8UCQ_B         405 LQAIKYYLCLSITRNGas-sVDRVFDICCEIFWLMLKYMRSSFKNEIEVFLNEIYLALl-AR-RNAPLSQKLTFVGILKR 481  Thermothiela...
5_pfamImport    62 LRMIQDDLFHHLIHYGis-sSTLVLSMICSTVLNIYHSLRSFIRVQLEAFLGFVLLRTa-GA--GSPSQLQEVALEAIIN 137 
XP_002324976   311 LRMIQDDLFHHLIHYGtr-sAPLLFSMICSIVLNIYHFLKRFIRLQLEAFFRFVILRVa-ST--GSSVHLQEVAVEAIIN 386 
22_pfamImport   62 LRMIQDDLFHHLVHYGts-sNPLVSSMICSIVLNIYHFLRRSVRLQLEAFFSFVLLKVa-SL--ANSLQLQEVAIEGIIN 137 
XP_002281184   316 LRMIEDDLFHHLIHYGmc-sSPLVLSMICSTVLNIYNFLRRFIRLQLEAFFTFVSFRVavQA--SSSLQLKEVALEAVIN 392 
F4K2K3         300 LRMVQDDLFHHLIHYGas-sSPLVLSMICSCILNIYHFLRKFMRLQLEAFFSFVLLRVt-AF--TGFLPLQEVALEGLIN 375  thale cress
XP_001420107   381 LNLVLDDLSRALCGVVts-cSPHVLAASTSLITIIYSEFREELKLHLEVFVRMVLLPLc-SSrNGVEEETQRVALEALVD 458 
XP_003055639   362 LELVQDDLCRAVLSVApa-gHPSTLAAVAAVILQLYLVMHSHLKLQLEAFLRMVLLPLg-EGaGGVPMESQRIALECLVD 439 
XP_002947274   277 ARLVQVELLHAMCQAVvqnpSIAVITGFCQTLLCVSTYLGHVSMAQLETVIQRVLLRLa-DGkGVPGLEQQEAALEGLLD 355 
XP_003533383   317 LRMIQDDLFHHLIYYGtw-sSSFILSMICSTVLNAYHFLRRFIRFQLEAFFGYVLFRIa-SF--GSTIPLQEVAVEGIIN 392  soybean

8UCQ_B         482 LCEDPRALVELYLNYDCNQN 501  Thermothielavioides terrestris
5_pfamImport   138 FCRQPSFIVEMYVNYDCDPI 157 
XP_002324976   387 FLRQSSFIMEVYVNYDCHPT 406 
22_pfamImport  138 FCRQPSFIVEVYVNYDCHPM 157 
XP_002281184   393 FCRQPTFIFEAYANYDCHII 412 
F4K2K3         376 FCRQPAFIVEAYVNYDCDPM 395  thale cress
XP_001420107   459 LCKNDNFATDLYMYYDCELT 478 
XP_003055639   440 LCRQPNFVPDVYLNFDCDME 459 
XP_002947274   356 LVRQPNFVHDMFVNCDCRLE 375 
XP_003533383   393 FCRQPTFIVEVFANYDCDPC 412  soybean
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