Conserved Protein Domain Family
AAA_8

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pfam12780: AAA_8 
P-loop containing dynein motor region D4
The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
Statistics
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PSSM-Id: 492896
Aligned: 17 rows
Threshold Bit Score: 349.242
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q57YY8       2956 MNLVFFTDALEHLCRIHRIVRQPRGNALLVGLGGSGRYSLTRLATYLAGYSIFSIETHKKYDLDRFHEDLRSLYKGCGLK 3035 Trypanosoma b...
4_pfamImport    1 MSLVFFPDAVRHLLRISRILRQPRGNAMLIGLAGSGRESLVHLATSMAGSTLVRVNVTHDYGIQKFEQDLKNAVLTAGID 80  
Q5LJP0       1829 MNLVFFREAIEHIVRILRVISQPRGHILNMGIGGSGRQVLTKLAAFILEMAVFQIEVTKKYKTGDFREDLKNLYKVTGIK 1908 fruit fly
Q7RIW0       2126 LPLVLFDYAIIQICKICRVLDFNISHLMLVGFGGSGKQSLIKLSIFINSLNLLNISTNNKYDVNCFKSDLQEFHLKCAIK 2205 Plasmodium yo...
5_pfamImport    1 IDITLFRYALQHLARICRVLAIPCGNLLMVGTGGSGRQSLTRLSSAIAGYGLRQPEITGTYGMQEWREDVKWVLKNSGGV 80  
3_pfamImport    1 IDLVLFDHALEHLSKICRILSIPYCNLIQVGMCGTGRQTLVKLACLIMNQNFFKIEITEKYKLDDWHRTVKAFLKEAGGY 80  
2_pfamImport    1 IDIVISQYILECLIKISRILIIPGSNLLIISSMGSGRKSIASLAAYIQQQELFEPSVQSYCDFNMWRKDIKMVLRKCGEL 80  
XP_013753128 2823 LELVFFRDAVKHLARILRILRQPRGSALLLGPDGCGRRSLARVAAHVAGYEVASVELSKGYGPAEFREDVKGVLGRAA-A 2901
XP_001581588 2304 LDLCLFSEAIQHLCRICRIIREPGRNGLLLGVGGSGRQSLTRLAAYICGVQLFQPEVSRSYSRVEWRQDLKRLLLDCGLQ 2383
XP_001309927 2808 MNLVLFKEASFHCCRIMRIIGRQFGHALLIGLGGSGRQSQCRLAANILEMQFFQITITKGYKERDFREDLKKVIDLTAIE 2887
Q57YY8       3036 GQ-QRVFYFSDNQIMQPAFLEDLNNMLSTGEVPNLFPKDELQNIRDTVCKQAIAS----GYRDTPDEMYNFFIDRARTNL 3110 Trypanosoma b...
4_pfamImport   81 TK-HTVFLLKDAQILDEAMLEDINCLLGSGEVPNLFTPDEEADIVIRVRDAVRAT----GKPDTRARSMAFFTAQVRDHL 155 
Q5LJP0       1909 QR-LTIFIFSSDQIAEVSFLEITNNMLSTGEI-NLFKSDEFDELKPELERPAKKN----GVLLTTEALYSYFILNVRDFL 1982 fruit fly
Q7RIW0       2206 PGtVHVLLLKEKEIL-DSFLPYINDLTSTGLCNDLFTKDEYLGIFSSIRNQIKYL----NIGESNEDVFNYYISKIRKNF 2280 Plasmodium yo...
5_pfamImport   81 GK-DFVFLLAEEQIRDDAFLDDVDSLLNDGEVPNIFNIEERQEIIEMTR--LAAQggdrNLDISVLNVLAFFVGRCREKL 157 
3_pfamImport   81 GR-PCTFFLKEGQIVIDTILDDLNYLLKSGEIPFIYSLEEKQELLDVVR--ASMQeeqpNIDESSESIFLYHQKRCKENL 157 
2_pfamImport   81 RQ-DFILFLKDKQV-KHNFLQDICCLLATGEISDLFSAEEKCNIIETIR--LHAQngnkNEEISNDAVMNFFLEQCRNKL 156 
XP_013753128 2902 GK-HVVFLLSDAQMVDEAFYDDVSNLLNSGEVPQLYSDDEEAMLVSSLRDAAKEA----GVDGSRHEVLAYAADMAREHL 2976
XP_001581588 2384 KK-ETVFLVSESQLIDESFFEDINCLLNSGDPPALFDDDDMEKIITGTTPLAKTL----GIVATRASVYSLFISQVKSHM 2458
XP_001309927 2888 QK-PTVFFFSDTHILQESFLEDVLSILTSGCVPNLFEGEELQQRREAMRAEATKR----KIVQTPQNLFNLYVQLSRENM 2962
Q57YY8       3111 HLVVAMSPAHKLFRARLRQFPALVSCTSIDWFVEWPSEALREVGLRYL--------------------------QETREn 3164 Trypanosoma b...
4_pfamImport  156 HIILCLDPSGATFRERIRNFPSLVNCSTIDWYNAWPKTALHSVAHRVLtela-------------------lvpSGPHEc 216 
Q5LJP0       1983 HVALCFSPIGENFRSYIRQYPALLSSTTPNWFRFWPQEALLEVASHFLigfplnvvvsgkedekhreslvisteAILQR- 2061 fruit fly
Q7RIW0       2281 KIAITHSPISNLYRNRLIKFPSLLSNFSFIYFLPWPYEALINVSNKFLddv--------------------einEELKK- 2339 Plasmodium yo...
5_pfamImport  158 HIMLCLSPIGDAFRIRLRMHPGLVNCCTIDWFDVWPEDALEQVARRTLvdl--------------------elaENVKD- 216 
3_pfamImport  158 HIIFSFNSANSKFRDYIKQYSSLRKFCEINYLKKWPKEALESIAKVWIqdl--------------------ninDETKS- 216 
2_pfamImport  157 HIIFCFRDVNKNIRSYLYKYPELIKYCTINWYEMWPTDTFLQVGLKYIedi--------------------nieENVKI- 215 
XP_013753128 2977 HIVLVMSPVGSGFRARIRQFPALVDCCTIDWFETWPREALLAVARARLssseav--------------vrvvgdAAALE- 3041
XP_001581588 2459 HVMIALSPIGSSFRRRVRMFPSLISCCTIDWFAEWPIEALENVSTRVIg------------------------------- 2507
XP_001309927 2963 HIVFSMSPAGNALRNRIRMFPPLVNNTTIDWFNEWPKQALQAVAENIMkdvd-------------------fkdENTKN- 3022
Q57YY8       3165 keddehlgIISDFFVYMHYTTSTLSREMLEQVHRYNYVTPSSYLDMVRGFRRM 3217 Trypanosoma brucei
4_pfamImport  217 gvgpklaaALIRTSVEVHGGVEPAAASFFSQLGRRIYVSPKSFLDFLRTFLNI 269 
Q5LJP0       2062 --------DIAYVFSVIHSSVAKMSENMYAEVKRYNYVTSPNYLQLVSGFKKL 2106 fruit fly
Q7RIW0       2340 --------NICEHMAYVHTSTNDMNKKYLEQKNRYNYVIPKTFLEYIYFYKNL 2384 Plasmodium yoelii yoelii
5_pfamImport  217 --------ESVVACKFFHSCTKDVSARFYELTGKKTYVTTASFLDLMRMFADL 261 
3_pfamImport  217 --------KVVNAFSYFHQEGEQI--------SNGVHVTPGSYLEFIRLYVDL 253 
2_pfamImport  216 --------NVIKVCIQLHNHMQKISTEYYKESNTKIHVTLTAYLHMLKLYVYL 260 
XP_013753128 3042 --------SVAQVAVSMYLSVAESTASFRASVRRAAYITPASFLRMLEQYEVL 3086
XP_001581588 2508 -------pEYSKFCASAHSIVSNYCQKFFEEMKRTNYVTPSTFLSFLNLITSL 2553
XP_001309927 3023 --------AIVGSFVEFHSLADGMCNKMQTQLKRSFQLTPTTFMEFVKNYKTL 3067
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