Conserved Protein Domain Family
Rax2

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pfam12768: Rax2 
Cortical protein marker for cell polarity
Diploid yeast cells repeatedly polarise and bud from their poles, due probably to the presence of highly stable membrane markers, and Rax2 is one such marker. It is inherited immutably at the cell cortex for multiple generations, and has a half-life exceeding several generations. The persistent inheritance of cortical protein markers would provide a means of coupling a cell's history with the future development of a precise morphogenetic form. Both Rax1 and Rax2 localize to the distal pole as well as to the division site and they interact both with each other and with Bud8p and Bud9p in the establishment and/or maintenance of the cortical markers for bipolar budding. thus Rax2 is likely to control cell polarity during vegetative growth, and in fission yeast this is done by regulating the localization of for3p.
Statistics
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PSSM-Id: 403848
View PSSM: pfam12768
Aligned: 69 rows
Threshold Bit Score: 105.722
Threshold Setting Gi: 356889830
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCH61493     1010 LALLNLNTYNVSIL--------LQNtNLTSFEFTGNQIAAW---------NSSTLFQYNNEAWSQIL-LPnGTES--LKL 1069 Tetrapisispor...
XP_002770498 1122 FITYKFGESSANSIskln-klgSKH-FVENFIISGMDNKDLdggm--vayGSDFIYGYDGSKWTRIDkEIkYSSD--TKF 1195 Debaryomyces ...
CCE87192     1109 FITYNFKDQSISTSsasklnslSSKnIVKNFVFSDVKSDGLsgpi--iayGSDFVTFFNGSGWQNIDkDFvYSDN--TSL 1184 Millerozyma f...
XP_002617589 1096 FAIYDFGTGSFEDAgktvndigISNdAIKKFIINDRVDNDLdfrm--vafGSGFVAGFDGNKWAKVDsAIdYSDE--TDF 1171 Clavispora lu...
EGW32505      825 FLIYNFDTGVFSTKds-----lNSGrPVEKFIITDTSNADLngrm--itvGKDFVAGFDGSKWNTIDsDIdYSQS--AKF 895  Spathaspora p...
CCE42534     1139 FLTYNFKGGSFDTEssln----slnkSVNRFILNDRSNSDSsgrm--iamGDDFISGFDGSKWSNIDsGIdYSDSqpAIF 1212 Candida parap...
XP_001386918 1130 FITYNFDKGTYSTQaaln-dlgSSK-VIKRFIINDYSNNDLkarl--vafGDDFVYGYDGSNWHQIDdDInFDNS--TTF 1203 Scheffersomyc...
EER33112     1139 FLTYNFQTAAFATKdtl---ndIDA-SVERFILNDENNKNLngrl--vamGQDSIYGFDGTHWNRIDdDIvYENY--TTF 1210 Candida tropi...
EMG49463     1009 FLTYNFDTGVFATKdpl---ngISG-NVQRFILNDQNNKNLngrlialgdGNS-ISGFDGTKWQRIDgDIiYDNF--TTL 1081 Candida malto...
XP_001485505 1099 FVTYDISKSAYSTDvksl----dsdeLVQKFILVDES---DmpngriiayGPGFVKAYDGKQWHSIDkDIlFDSA--TEL 1169 Meyerozyma gu...
CCH61493     1070 DSISIFDIT---NKNSSsilEKRaLRDTNIMVATGQFYSKGLGTVQALYYTSDTWIPYFYGnltnnmDTSNsinifPNKD 1146 Tetrapisispor...
XP_002770498 1196 TALTLLDLEk-aNSKNK---EAY-FDKNKVLIVSGAFELSDYGLVNAALYDGTNWTPYIYS------SRNN------KLG 1258 Debaryomyces ...
CCE87192     1185 KDVTFIESSk-hKGNSK---SVN-ISNNKLLILAGKFELSPFGHLNTAIFNGSHWFPYLFS------SKGK------EYG 1247 Millerozyma f...
XP_002617589 1172 QDLKLVELKnpiSSNSR---QSY-FDKDKAVVLSGTFNISKYGLVNAAIYDGNSWIPYIFS------QDSN-----AKVG 1236 Clavispora lu...
EGW32505      896 TDVKLLTVEk--STDYN---QTY-FNNNQILILAGTFSLKQYGPVNAAFFNGTSWIPYIFT------STQT-----NKLG 958  Spathaspora p...
CCE42534     1213 HDLKLLTLSk-sSSSYN---GDL-FDKNNILLVAGTYALKDYGLVNMALYNGTSWIPYVYT------TSPNs---fSTIG 1278 Candida parap...
XP_001386918 1204 SDLKLLDLKn-kNGQYN---STL-FSQGNILALAGAYSLKDYGLVNVALYNGSQWIPYVYT------TSGA-----NQLG 1267 Scheffersomyc...
EER33112     1211 NDIKLLTLSs--SSNYN---GTY-FDKSNILTVAGIFDLKDYGLVNMALYNGTSWIPYVFT------SQSSdssnsLEIG 1278 Candida tropi...
EMG49463     1082 NDLKLLTVAq--NTNYN---ETY-FAKNKVLTVAGTFALKGYGLVNMALFNGTSWIPYVFTs----qESAG-----SQIG 1146 Candida malto...
XP_001485505 1170 TDIKLLPLKk-sNTANK---QTY-FDKNQVLALAGRFNLTDYGPVNLALFNSTSWTPFVFT------KQNS------TLG 1232 Meyerozyma gu...
CCH61493     1147 ISSKIISDfvlKNWNFNlsdvgnstnttnstnttsttnltspsnttspqpsssiipiigkqqNKKHKIQRGFVVLIGLAL 1226 Tetrapisispor...
XP_002770498 1259 EITTILIK---DDIRFQssd----------------------------------------dlSSPKNLSEGKVVGISLAC 1295 Debaryomyces ...
CCE87192     1248 TINSIHLK---DVSRIDwsa---------------------------------------rleKQFHKMSRGKVVGISLAC 1285 Millerozyma f...
XP_002617589 1237 SINTLLLE---EVYRFQsss---------------------------------------dlkKGKSKLSTGKVVGISLAC 1274 Clavispora lu...
EGW32505      959 NIQSLLIQ---DSYRFQss-----------------------------------------qdLTPKLLSRGKVVGISFAA 994  Spathaspora p...
CCE42534     1279 DVRTILID---DYYRLQssd---------------------------------------dlkNLHNYLSRGKVVGISLAC 1316 Candida parap...
XP_001386918 1268 QVKTMLID---DSYRFQssd----------------------------------------diSSVKHLSKGKVVGISLAC 1304 Scheffersomyc...
EER33112     1279 DIRSILID---DSNRFQssd---------------------------------------dlkSKNRFLSRGKVVGISLAC 1316 Candida tropi...
EMG49463     1147 EISSLLID---DPYRFQssd---------------------------------------dlkNQNRFLSRGKIVGISLAC 1184 Candida malto...
XP_001485505 1233 SIGSILMK---DSLRLQsle----------------------------------------dvKKESKMTRGQVVGVSLAA 1269 Meyerozyma gu...
CCH61493     1227 SLATVALLGIFGILLSF--IFRDSRGdYESLKP----RTTEHEMFDAVPP 1270 Tetrapisispora blattae CBS 6284
XP_002770498 1296 ALGSTTLIGLLYIIPFLa-LSRKNKE-HDN-SQ----RIQENDMMNAVNP 1338 Debaryomyces hansenii CBS767
CCE87192     1286 AIGSTMVVGLLYLIPAL--LFLRKNK-ERGNDQ----RIEEKEMMEAVRP 1328 Millerozyma farinosa CBS 7064
XP_002617589 1275 AIGSTFFLGLLYFIPLLy-LFKSSEK-SENVNQ----RIHEDEMMHAVRP 1318 Clavispora lusitaniae ATCC 42720
EGW32505      995 AVGSTVVLALLYIIPYFv-LFKKKES-HGQFERaegmRIHEKDMLDAVNP 1042 Spathaspora passalidarum NRRL Y-27907
CCE42534     1317 ALGSTSLFGLLYLIPYLa-LFKNRKG-YVQ-------RIQEQDMIDSVNP 1357 Candida parapsilosis
XP_001386918 1305 ALGSTTILGLLYVIPYFllFRKQRDE-EVLHQQ----RIEEDQMMKTVNP 1349 Scheffersomyces stipitis CBS 6054
EER33112     1317 ALGSTTLLGLLYIIPYFalFRPRKDG-YVPAQR-----IEENEMMNAVNP 1360 Candida tropicalis MYA-3404
EMG49463     1185 ALGSTALLGLLYIIPYFalFRNRKDG-YVQGRR-----IEENDMMHAVNP 1228 Candida maltosa Xu316
XP_001485505 1270 ALGSTALMGLLYLIPYY--AFFRQNN-RKGAQQ----RIHENEMMDAVNP 1312 Meyerozyma guilliermondii ATCC 6260
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