Conserved Protein Domain Family
End3

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pfam12761: End3 
Actin cytoskeleton-regulatory complex protein END3
Endocytosis is accomplished through the sequential recruitment at endocytic sites of proteins that drive cargo sorting, membrane invagination and vesicle release. End3p is part of the coat module protein complex Pan1, along with Pan1p, Sla1p, and Sla2p. The proteins in this complex are regulated by phosphorylation events. End3p also regulates the cortical actin cytoskeleton. The subunits of the Pan1 complex are homologous to mammalian intersectin.
Statistics
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PSSM-Id: 403842
View PSSM: pfam12761
Aligned: 46 rows
Threshold Bit Score: 164.779
Threshold Setting Gi: 387513978
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEA25677             191 NKDASLAFLHILNFRHE-GFRIPRTVPPSLRASFESNKIDYQV--DNvr------pAQKWGADGDTETTTGRKAKFGDTY 261 Talarom...
WGS:AFWA:PNEG_00976  190 EKDQAFYFLHILNQRNK-GIRVPSVVPANLRATFEKNPVDYNI--NEvssykndhkNAIFPQSSKHTSPVKKY------- 259 Pneumoc...
CCE40165             189 DKDQTLVFLHILNQREN-GKRVPRGVPASLRATFSKEVPSYDL--------------SAQAKPLETTKTQASKRSFAESY 253 Candida...
XP_013935177         189 DKDQCLVFLHILSQRSS-GKRVPKSVPPSLRATFNRETPSYDV--ND-------------YQAEERKKPSSTKQAFGESY 252 Ogataea...
LoveMIT:GQ68_04400T0 194 DKDQCLVFLHILNQRSN-GKRVPRGVPASLRATFSKETPTYDLksSQaq----------vTKPSSAPGHESRKHSFADSY 262 Komagat...
EPB83755             230 tQDQCLMFYHVLNQRTR-GIRIPKELPPDLHAAFA----------GEyaadfgerpGSGTGARKGTNQSMSNSAKLADSY 298 Mucor c...
Q755V2               189 DRDPVMYLFHLLRQRSDvGAKIPAGVPASLGETFAKERVTTDI--ANegqgairksELHIASASRSNSARPK-------- 258 Eremoth...
XP_003646946         191 DRDPVFYVLHILKQRNDlGIKIPSSVPSALKEVFSKERVSTDI--SGgaqgtvrkgSTYVSSSGNKGVTDNGRRK----- 263 Eremoth...
CAR24967             214 NRDPAFYLIHALKQRNDmGCELPSELPHAIKEICNQHRVSYDL--NSsqadvkrssSPTKPADYHASASVR--------- 282 Lachanc...
CCE91312             186 DKDPAFYFIHCLRQFNDvGARIPSELPKAMADICNKERVSYDL--NSpqadvkkviSEPSQTSKSNTQETGKSGGH---- 259 Torulas...
EEA25677             262 LSRLGv--K-StyrPQGTDFSNTIqDEEWE-KVRLRRELAELEQKLEAANRVSDER--RsgdasSSTRQd-GRPnwAIIK 334 Talarom...
WGS:AFWA:PNEG_00976  260 --------------DSSKEMHATY-VEDSN-MDGIRQKRQEIHYQGKKYRSDGSDEhiSh----------------NIIL 307 Pneumoc...
CCE40165             254 LSKIGhgsNgNa--EKGTDFSATE-GTDWE-EVRLKRELANLEKLLSEVQNRSK-----------ADEKesEEQ--RMIK 316 Candida...
XP_013935177         253 LSKITgssKiP---NNKTDFSATD-GTDWE-EVKLRRELKELEELIQKAEDAKN------------NKGldDKL--SLAK 313 Ogataea...
LoveMIT:GQ68_04400T0 263 LSKIGasqNsSa--EVGTDFSATK-DTDWE-EVRLTRQLQDLEELISKVEKDRSQR--------LDPDPavNAS--SMTK 328 Komagat...
EPB83755             299 VNRLGa-------aSTSLSSKSTKaGNKYDeEDMLKRELAELKERVKEAERKANEa-------kESENYesFAS--RPLR 362 Mucor c...
Q755V2               259 --------------NENSDYSATA-GTDWE-VVQLQRELAALDSQLSDLKQ-------------QQESAppTRA--EVLR 307 Eremoth...
XP_003646946         264 --------------MAGTDFSATK-GTDWE-LVRLQRELANLETELASLNR-------------EQSVPcsSGP--KTLE 312 Eremoth...
CAR24967             283 --------------ERSSNFRSGG-GAEGE-VGQIKKQIADLDAQPSGTPQVV-----------SNPSDvpSDP--NTAR 333 Lachanc...
CCE91312             260 --------------RQAASYSSVDsVTDIE---TLERDLAQLDTELSQVE--------------AKNASasSQNsvRTLR 308 Torulas...
EEA25677             335 KEALQLLEYKERELREMKEGTGRTKDgQD-LERLREDIKTVADQVDGLK---DHLDRRNEVLAELR 396 Talaromyces marneffei...
WGS:AFWA:PNEG_00976  308 AELEQMLEFKKNELKLLKEGNIKSVTgMNdLESVQSDVLVMKQQIDNLG---SYLIKKTDELQKLR 370 Pneumocystis murina B123
CCE40165             317 YEFEQLLKYKQDQYNRQQSGSGQ----DD-LSKVENDIKDLETQAESLQ---EYLDSRSQELARLN 374 Candida parapsilosis
XP_013935177         314 YEFENLLKYKEQQVAELGTG-------SD-LQSIRANIEVVQSQVSQLE---SFLEQKRTELGGLQ 368 Ogataea parapolymorph...
LoveMIT:GQ68_04400T0 329 YELEQLLKYKEDKLTSLKSSNGASS--GS-LSSIKADVDLIESQVQTLQ---EYLQSKKEELKQLQ 388 Komagataella phaffii ...
EPB83755             363 DQFQALYDYKLRQLTDQSDIE------DK-VRKQERDIDAARDAVRRLNrivDDVRSKKRELESll 421 Mucor circinelloides ...
Q755V2               308 EQFEGLLKFKQAQL----STSTNSSPaMN-VLSLTEDIDSLEEQVTVLQ---HYLSTRSETLQQLQ 365 Eremothecium gossypii...
XP_003646946         313 QQFQGLLTYKQNQL----SNSTTSQSsIG-VLGLIDDIDSLEGQVQILE---QYLSSKRGELHNLQ 370 Eremothecium cymbalar...
CAR24967             334 KQFEELLRYREEQLRYSGNTHNGS---IN-VKGIKEDLKTIAQQVGVLE---QFLANKKQELQQLQ 392 Lachancea thermotoler...
CCE91312             309 EQFEGLLRYKQQQTLEHTENSRISVP-IN-SRAVKEDLDNIEEQITILE---SYLSNRQSELQSLR 369 Torulaspora delbrueckii
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