Conserved Protein Domain Family
Vac14_Fab1_bd

?
pfam12755: Vac14_Fab1_bd 
Vacuolar 14 Fab1-binding region
Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. This domain appears to be the one responsible for binding to Fab1. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.
Statistics
?
PSSM-Id: 403838
View PSSM: pfam12755
Aligned: 27 rows
Threshold Bit Score: 131.95
Threshold Setting Gi: 124452248
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_002287142  506 DARKGGAVALAACAIGLKKAnegrrdVMECRDLILASVVHACQDHSQRVRYYATESLFNVTKVIPSLAVQHFFILFEILR 585  Thalassiosira...
A2VE70         67 HSRKGGLIGLAACSIALGKD------SGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLS 140  cattle
XP_002070532   65 NRRKGALIGLAATGLGLGKD------SDKYVNELVMPIINCLSDPDLRVRYFACESLYNVVKVSRAAIIPFFPELFAALS 138  Drosophila wi...
Q7QE90         65 NKKKGGLIALAATSIALGKD------TEKFIEDIVNPIMNCLIDNDNRVRFFASESLYNVVKVARGAVLPFFPSVFNALS 138  Anopheles gam...
Q16Q69         65 NKKKGGLIALAATSIALGRD------TERFIEEIVNPILNCLMDTDTRVRYFASESLFNVVKVSRGSIIPLFPSLFTSLS 138  yellow fever ...
XP_002639898   65 NQRKGGLIGMAASSIALGNKn-----APPYTAKLVEPIVPCFLDADLQIRYYACESLYNIAKICKTAVLDHFGDIFDVLW 139  Caenorhabditi...
Q4UF45         78 NLRIGGLMAMACTALSLEKY------LLDFCEKFIKLVILSFYDQDNKVRYYSCEALYNIVKKCKVESISCISEIFDGIC 151  Theileria ann...
EDO06722       79 EYRIGGMIGLASAAIALDAH------LNRHGDTFIKLVLPYFTDQDST-------SLYNIIKKAKQASMRCFNDIFDGVC 145  Babesia bovis
ESS31638      148 NHRKGGLVALASVAIALEAQ------VSPFLPFLLPPLLRAFSDPEPRVRYYACEALYNVLKVAQTSALPFLNDIFDGIC 221  Toxoplasma go...
EEC51351      366 DARKGGVVALAACAIGLKKAelqdsaAEECRDLILASVVHACQDHSQRVRYYATESLYNTVKAIPNLAVQHFFILYEILR 445  Phaeodactylum...
XP_002287142  586 SLYADVDLDVRSGAELLDKKLKE 608  Thalassiosira pseudonana CCMP1335
A2VE70        141 KLAADPDPNVKSGSELLDRLLKD 163  cattle
XP_002070532  139 RLVTDSDQSVKDASELIDRLLKD 161  Drosophila willistoni
Q7QE90        139 RLVTDPDQTIKNGSEILDRLLKD 161  Anopheles gambiae str. PEST
Q16Q69        139 RLVTDPDHSVKNGSELLDRQLKD 161  yellow fever mosquito
XP_002639898  140 RVTADSDQNVRGGAELLNRLITE 162  Caenorhabditis briggsae
Q4UF45        152 KLTCDIDEDVKYASQILNRLLCD 174  Theileria annulata
EDO06722      146 KLCCDEDEDVRQSSQFINRLLKE 168  Babesia bovis
ESS31638      222 KLYGDVDLDVRGGVVFVDRLLKE 244  Toxoplasma gondii VEG
EEC51351      446 SLYADVDGNVRGGAETLDKTLKQ 468  Phaeodactylum tricornutum CCAP 1055/1
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap