Conserved Protein Domain Family
HGTP_anticodon2

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pfam12745: HGTP_anticodon2 
Anticodon binding domain of tRNAs
This is an HGTP_anticodon binding domain, found largely on Gcn2 proteins which bind tRNA to down regulate translation in certain stress situations.
Statistics
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PSSM-Id: 403832
View PSSM: pfam12745
Aligned: 55 rows
Threshold Bit Score: 229.421
Threshold Setting Gi: 409043451
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002770831        1464 WKKSRCDVLVTSLNESYIRLSGYEIVKSLWAHDISSDI--F---TSTSLEDIAHKTDIDGANWVVLIKQPNslqk----- 1533 Debary...
XP_003050523        1360 FNTRRCDVLVASFDAALLRSSGVELLQMLWAHDISAEMakD---AR-SPDELLSKHRDEVYSWIIIIKQ----------- 1424 [Nectr...
EFX02753            1425 FSAKRCDVLVASFDPTILRSVGVELVRTLWAHGISAELagD---AR-STEELVSKNRDEGHAWIAIVKQDGvvkirtmpa 1500 Grosma...
XP_006693326        1380 FSAKRCDVLVASFDPSILRSSGIELLQMLWAHGISAELarD---AR-SPEDLLTTYRDESYSWIVIIKQ----------- 1444 Chaeto...
CDP26091            1374 FSMKRCDVLIASFDPSVLRSSGIELLQMLWAHNISAELarD---TR-SPEDLLSSYREESYSWIVIIKQ----------- 1438 Podosp...
XP_003344545        1374 FNIKRCDVLVASFDPEVLRSSGIELVQTLWAHCISAELarD---AR-SPEDLLSKYRDESYSWIVIIKQ----------- 1438 Sordar...
WGS:AATM:SJAG_00169 1324 WIPRRLDVIVASIGKDSL-TEKCAVLRILWALNIKADVlhK---GATSLEEVVTRFRNDGINWVLVVRQKN--------- 1390 Schizo...
XP_013022734        1322 WLPRRVDVLVTSIGKDSL-MEKCALLQELWSLNIRADIvlR---GATSLEEIVTRFKSEGVNWVLVVRQKN--------- 1388 Schizo...
Q9HGN1              1326 WAPRRVDVLVTSIGKDSI-LEKCSLLQELWALNIQADIvlR---GASSLEEIVTHYRSEGINWVLVVRQKN--------- 1392 Schizo...
EKM52933            1324 WSPRRCDVYVVSHQSGHL-ADRLEVTSLLWRNSISADMmyEfglQTVEHENVVEQCSREGILFIVYPRPRN--------- 1393 Phaner...
XP_002770831        1534 ------skqkRSTGKFKPLRVKNVITNK--VSDIEYEELVQFLQSEIEE-RNnddeFDNLAGSgstESTREGLKSDHNED 1604 Debary...
XP_003050523        1425 ------------DSI---LKIKSMGRKDapDVDIPSTQLLSWLRGEIRE-RD----ARSVVKLr----gNSSQAEPSGSG 1480 [Nectr...
EFX02753            1501 satgggglgsGSGSA-----AAHRNNAP--DVEMALSQVMAWLRAEMRE-REs--tRTGTITKasaA-AAAASSSLEGSS 1569 Grosma...
XP_006693326        1445 ------------ESQ---LKIKTMHRKDvpDADIQAKDLLAWLKAEIRE-RE----SRSGLKIragLIPQSELSGVMPGA 1504 Chaeto...
CDP26091            1439 ------------DNM---VKVKSMGRKDasDADISATDLLNWLKSEIRE-RD----SRVLAKTrsmPTAAHVDSANAIEG 1498 Podosp...
XP_003344545        1439 ------------DNM---LKIKTMGRKDapDADIPAKELLNWLKAEMREnRDa--qMRGTGAGghhGGGISSGAAIKF-R 1500 Sordar...
WGS:AATM:SJAG_00169 1391 ------------TAMQNSIKVRNISKGE--DYEIRTEEIGLWMLSEINE-R-----KRLKNTKqttELSRTSSQEAFSQM 1450 Schizo...
XP_013022734        1389 ------------TQMEHSVKARNIMKNE--DDEIKIDEIGVWLLGEINE-RK-----RNENLSqtrQIIDSDIQDYGKY- 1447 Schizo...
Q9HGN1              1393 ------------TQMEHSVKARNILKNE--DDEIRFDEVGMWLLGEINE-R-----KRNESMLqskRILDSAQQDVAKFV 1452 Schizo...
EKM52933            1394 -----------ARRDQPAFKVKSVLKGV--EYELSKQELVPFLHQQIAE-QKr--iDASLSGApliSVAEGTQAVAA--- 1454 Phaner...
XP_002770831        1605 se----------sDKLSIrsgPIFTVDiDQKVVVV--PNAAPRGR-KNNKKEKWEIENDSKLASASLIKNVA-----NSP 1666 Debary...
XP_003050523        1481 -------------------------DKdPEQEVRV--LIAQTRSK-KFNRRTVVEQ---AQVSASSVVRSFL-----DGP 1524 [Nectr...
EFX02753            1570 vg----------gSHGFGhhaANEHDGyDGQDVRV--LVGHNKSK-KFNRQAVVEQ---AQVNAARLVRSFL-----AGP 1628 Grosma...
XP_006693326        1505 ---------------SAGlggGGAGGYeQQQDVHV--LVAQTKSK-KFNRRAVVEQ---AQASAARLVQGFL-----EGP 1558 Chaeto...
CDP26091            1499 d---------------------------REQEVHI--LVAQTKSK-KFNRHAVVEQ---AQTSASRLVKGFL-----EGP 1540 Podosp...
XP_003344545        1501 gggggaglssfgnNSELNnnlFLGADGeREQEVHV--LVAQTKSK-KFNRRQVVEQ---AQTSAARLLQSFL-----DGP 1569 Sordar...
WGS:AATM:SJAG_00169 1451 ----------------------------EGQDLNL--DVQLVSLKdVNDRKYKWKHKMNAMNKVYDLVKNAIsdcstDAV 1500 Schizo...
XP_013022734        1448 --------------------------NdSSSDIDL--DVQLVPLKgASDRKYKWKHKQNAMNKVNDLVQSAIhdstkDAL 1499 Schizo...
Q9HGN1              1453 ----------------------------DTSQSNL--DVQLISLKdVNDRKYKWKHKQNAMNKVYDLVQSAIresseDAI 1502 Schizo...
EKM52933            1455 ------------------------SKEaTGPEVQLllQGDAKKQR-KQTKQMYM---DRAFEFGVDLKNAMAq---sNVP 1503 Phaner...
XP_002770831        1667 IITIDARDEVLDMISI--TSLNQPDEWiRKVIFSNNNLPKSFATNIYNTLK-----KEASKGTR-----WVILHSSKTDK 1734 Debary...
XP_003050523        1525 ILAIETTDQVMDLIRE--TCLSEPESW-RQVEHAVTTSEKKYIREIHDQLD-----TWRYKFEKknctrHSFLYNFRSGN 1596 [Nectr...
EFX02753            1629 IAAVETTDQVLTMIQA--TSLSDPDSW-RRLEQNVNTVEKKYVREVQGMLVdwrtaYEVGTGSR-----HAFVYNFRTGT 1700 Grosma...
XP_006693326        1559 IAAIETSDTVVDMIKN--TSLSDSESW-RKVEQSVGTAEKNYVRDIHDMLT-----KWRWEFEEkkgpgHAFVYNFRTGK 1630 Chaeto...
CDP26091            1541 IAAIETSDTVMDMIKS--TNIADAESW-RKVEQNVGTAEKKYVREIHEMLKg---wRWEWETKKgp--gHAFVYNFRTGK 1612 Podosp...
XP_003344545        1570 IAAIETSDNVMEMIRR--TSLSDAESW-RKVEHNVGTSEKKYVKEIHDMLKg---wRWEWEAKKgs--eHAFVYNFRTGT 1641 Sordar...
WGS:AATM:SJAG_00169 1501 ALAVDCSTEVMHNLRS--TTLQNEESW-KRFIDSSPASQRQYLEQLHQKLL-----AFKEEGKQ-----RVWVASFRTNE 1567 Schizo...
XP_013022734        1500 ALAVDCDAGAMQGLKS--TSLKDDNSW-KKLIDSCPASQREYMQRLQTKLT-----NLAEKGRN-----RVWICSFRTNE 1566 Schizo...
Q9HGN1              1503 ALAVDCDSEAMEKLRS--TTTLDEESW-KRLIESCPASQREYMQRLQKKLV-----TLAEQDKK-----RVWICSFRTNE 1569 Schizo...
EKM52933            1504 IVAVDVSDSLFDQMTKstMWLSDENAW-KALVAQFPTSQSSYAHQIREAVL-----RRKADGCK-----FLILFAVKEER 1572 Phaner...
XP_002770831        1735 TCIIDL 1740 Debaryomyces hansenii CBS767
XP_003050523        1597 CIYYDL 1602 [Nectria] haematococca mpVI 77-13-4
EFX02753            1701 CIYYDL 1706 Grosmannia clavigera kw1407
XP_006693326        1631 CIYYDL 1636 Chaetomium thermophilum var. thermophilum DSM 1495
CDP26091            1613 CIYYDL 1618 Podospora anserina S mat+
XP_003344545        1642 CIYYNL 1647 Sordaria macrospora k-hell
WGS:AATM:SJAG_00169 1568 LCLYEL 1573 Schizosaccharomyces japonicus yFS275
XP_013022734        1567 IYLYGL 1572 Schizosaccharomyces cryophilus OY26
Q9HGN1              1570 IYLYGL 1575 Schizosaccharomyces pombe 972h-
EKM52933            1573 PFLINL 1578 Phanerochaete carnosa HHB-10118-sp
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