7KMT


Conserved Protein Domain Family
TRAPPC-Trs85

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pfam12739: TRAPPC-Trs85 (This model is not part of the current CDD release)
ER-Golgi trafficking TRAPP I complex 85 kDa subunit
This family is one of the subunits of the TRAPP Golgi trafficking complex. TRAPP subunits are found in two different sized complexes, TRAPP I and TRAPP II, and this Trs85 is in the smaller complex. TRAPP I, but Not TRAPP II, functions in ER-Golgi transport. Trs85p was reported to function in the cytosol-to-vacuole targeting pathway, suggesting a role for this subunit in autophagy as well as in secretion. The overall architecture of TRAPP I shows the other components to be Bet3p (TRAPPC3), Bet5p (TRAPPC1), Trs20p (TRAPPC2) , Trs23p (TRAPPC4), Trs31p (TRAPPC5), Trs33p (TRAPPC6a and b) and Trs85p.
Statistics
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PSSM-Id: 520422
Aligned: 61 rows
Threshold Bit Score: 221.008
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7KMT_B         50 ISNAI-APVITVTSTPLFDKHIQETYKVDsLYMLLRFFGGCvs------------------------------------- 91   brewer's yeast
7_pfamImport    1 IQDSF-VPMVAVLCSEEAERVTNKNHLS--FSELLRPFC-Rlt------------------------------------- 39  
XP_011612710   12 IQDSF-VPMVAVLCSEEAERVTNKNNLN--FAELLRPFC-Rlt------------------------------------- 50  
XP_011471282   12 LQDSF-VPMVAVLCSKEADRVSRKNKLS--FPELLRPFC-Rll------------------------------------- 50  
5_pfamImport    1 VQDSF-VPMVAVLCSEEAERVTRKNNLN--FAELLRPFC-Rlt------------------------------------- 39  
XP_002065801   15 IKNIF-SPLIGVLSSPLADEACQRNNLT--FVELLQPFA-Klp------------------------------------- 53  
XP_002896973    8 VQDTF-APVVLTCTTSEAERIAQKNNLS--VANLLNGFARLed------------------------------------- 47  
Q57ZE9          7 VESRYrHPVVVVLASRTADEAARRNGMD--LINMIRPFAVYdg------------------------------------d 48   Trypanosoma b...
XP_003064587   11 VRARF-TPVVACVTTPEVDAACAATGLS--FVDILRPHARVtg------------------------------------- 50  
XP_002142650   12 LTELF-PSHVVVFGSNQAQDFLR-SEFGLdVSRLLRPFGTDraskylwaennnltsndndidikwrervcleyyrywpys 89  
7KMT_B         92 dRDQAneakvgqhehevcdasdstdsipknknlevpnlskkgsRSRSNSLFQR--------------------DSTQSQY 151  brewer's yeast
7_pfamImport   40 sEGHI--------------------------------------RDPNNQLHVV--------------------KNLRICV 61  
XP_011612710   51 sEGHI--------------------------------------RDPNNQLHIV--------------------KNLRICV 72  
XP_011471282   51 sEGHI--------------------------------------RDPNNQLQTV--------------------KNLRICV 72  
5_pfamImport   40 sEGHI--------------------------------------RDPSNQVQLV--------------------KNLRICV 61  
XP_002065801   54 nDAHF--------------------------------------RDVSGTSVSV--------------------RGLRLNF 75  
XP_002896973   48 aDTPL--------------------------------------RSVTHPI-QL--------------------ARFNFRF 68  
Q57ZE9         49 lFARL--------------------------------------TDRADATLV---------------------RNFGVRL 69   Trypanosoma b...
XP_003064587   51 iEVQM--------------------------------------RTSPEHVAVT--------------------TSYSVRF 72  
XP_002142650   90 kNIMM--------------------------------------NKPPDSDHIWfsnnthfsvkinamnkmikaDNINIRF 131 
7KMT_B        152 IRFTRPLGDLIetrdand----------------mlfnyhsLEVFLDNYLKLVAANTDEMvphnl---------lkksiY 206  brewer's yeast
7_pfamImport   62 SSVTSGSSAPSatlspaqgrv----------lgdvvsscqlHEGALTSAITAGDYDLSVSat---------------tpW 116 
XP_011612710   73 NNVMTSSSAPSatlsqaqcrv----------lhdvvsscqpHEGAVSNVVTAGDYDLSVTat---------------tpW 127 
XP_011471282   73 NAVTTNPVSSPavlspaqyrq----------lgevvsscqpLEGAAATSFKTGDYNLNLSvt---------------tpW 127 
5_pfamImport   62 NNVVTSPNPACaafspaqrrl----------lnevvsscqpQEGAATNVITAGDYDLNFSat---------------tpW 116 
XP_002065801   76 CDVDWRPPQTVlarkmlnd------------------svtnahnDKTKVVTIADMDLELPts---------------epW 122 
XP_002896973   69 LTASQFHTLGVneateqlnatik-------rhppqhdaasaVELDIPRVTNVDDVPTYLRvigadada---egsndpmpW 138 
Q57ZE9         70 TR-AQCVREVGettllhhlrdllc-----gqsevelalgeqLDRALQCLMKKGGGVLTDTrvsaelgst--llershpdW 141  Trypanosoma b...
XP_003064587   73 HSVAEAKRAAPydvveahlarafa----ttrwaaggasgdaLAGALDDVPKDVEALIARArgevrsps----dekwwtpW 144 
XP_002142650  132 ISLCNTKKDVRemyedltvravescrqfsrsfsmseivskiISGTGRKYIESLAKEILKKedsslvnnvpfigisglpiW 211 
7KMT_B        207 HSFFSLAISSTNNLSPYETFNHPILS-----LIALDISNGEVYEDARDLLVNFKNl--nHNTENFPIFMN---------- 269  brewer's yeast
7_pfamImport  117 FESYRENFLQSMPASDHEFLNHYLACs----LLVVSSTEAVPSEQFLKLSQQHRIq--hSGEYSSPKWFI---------- 180 
XP_011612710  128 FESYRENFLKSMPASDHEFLNHYLAC-----LLVVSSTEAVPLEQFLKLSQEQHRiq-hSGEYTNPKWFI---------- 191 
XP_011471282  128 FEAYRENFLQSMPASEHEFLNHYLAC-----LLVVSSTEAVPVEQFLKLSQEQHRiq-hSGEYTHPRWFI---------- 191 
5_pfamImport  117 FEAYRENFLQTMAASEHEFLNHYLACilpqgLLVVSSTETVPVEQFLKLSQEQHRiq-hSGDYTNPKWFI---------- 185 
XP_002065801  123 FEQWRETFLTVQFPAEHEFTRHLLSC-----LLILSSADPQIVETAHKLTQRVQQmq-sITPQKLPKWFH---------- 186 
XP_002896973  139 YRSFKHTLMDTFRCEEYSLLCHPVAM-----LMVVSSTDPNPRHSFEELTSPRNL----PAPFQMG-LYD---------- 198 
Q57ZE9        142 HRQFVQNYVYSVRCSHFDTTDHPVGF-----IYAASTNASGGVEGILKEFNELKR-----GQEIGEIWRNmp-------- 203  Trypanosoma b...
XP_003064587  145 FDAYRAELDDRLAFHDHEAIDVPAGV-----VFAVSASSSDPLGDATRMTEDGSSw--pGGLPNQP-LLEra-------- 208 
XP_002142650  212 LERWFQVFYSELNFATHETISQPIGG-----MIFVLINEESLDKTCETILDGLRTgisfTNIDGNSNYYHnqgyfrshyl 286 
7KMT_B        270 ----TNE-MLPVFLLCYnDDSQE--EFEKCQALAKKLKK-QLFVE-SILLALwkd------sfiYDENSv---------- 324  brewer's yeast
7_pfamImport  181 -----PN-TLKYYVLLH-DVGEG--SEDRANVVYEDMKQ-RYGPQgCALLRTntrp----vsvdSGEQIpdpwgqylhtn 246 
XP_011612710  192 -----PN-TLKYYVLLH-DMSEG--NEERANLSYEDMKQ-RYGPQgCALLKMntrs----isadNGEQIpdpwcqylhan 257 
XP_011471282  192 -----PN-TLKYYVLLH-DLSEG--DEQRAETVYEDMKQ-RYGSQgCYLLKInsra----vsaeEDEQIpdpwsqylhkn 257 
5_pfamImport  186 -----PN-TLKYYVLLH-DMGEG--GEQRADAVYEDMKQ-RYGHQgCYLLKVnsrs----ssaeDDEQMpdpwsqylhrs 251 
XP_002065801  187 -----PSeVLNSYVVLH-EARQG--DLSKAQQAFEMLKS-TFGDSkCFLISInsne----ggqpAAQDMqdlwkdyikrq 253 
XP_002896973  199 ----ATL-VPKFFVVLH-DVLETegTSIDPDAILRSM---NISTVnGAVLKIns--------lpVESAPvpsqfs----- 256 
Q57ZE9        204 ---cMEEeMHSHFLLLH-DVTEGp-GMDEVNRMFAAVQS-SLGHAnCALVKLnsi------snpQNVKNmdpsvwtdanp 271  Trypanosoma b...
XP_003064587  209 ---gDVDvFARHYVLVH-DARDAt-ATREAVAAKERILAdAFGDAkVSVLPVns--------ssSFSSSphdddiwt--- 272 
XP_002142650  287 qetyLND-FPLVFILIS-DSSLEdnCNLDVQSIISKLKQ-LFPENeFYLWNIkgiskcscsesiFEEQKvd--------- 354 
7KMT_B        325 -------------------------------------------------------------------IQLHQPV-----M 332  brewer's yeast
7_pfamImport  247 hpstqdapedvaasp--------------------------gsgrrseqpeltvtllpdgacssldsSPLKPDTpaglgS 300 
XP_011612710  258 ylsnqevlediapaaslpaens-------------vsvaeedshhsgkdgvcnnreisplkldtlssLGSLHSV-----S 319 
XP_011471282  258 nlryqdpadgapaa-----------------------------ekggdeegggesgclnndplqleaDSSSTSL-----T 303 
5_pfamImport  252 nmqnqededaavssgpaenntsa----------aeflhrrppdgastgleghplqldtasspgslhaLSAEQPE-----L 316 
XP_002065801  254 pkstlaqegssdpsapkspqeatsavgsmpamqmsvlqeqeqdvvgmlhplspmqesatdalstrlsISSESIA-----S 328 
XP_002896973  257 -------------------------------------------------------------tvwtdnPYVRPPL-----F 270 
Q57ZE9        272 sfmdvpsdtacra-------------------------------vrysqqlesrsgspasaggggdsASSRVAA-----E 315  Trypanosoma b...
XP_003064587  273 -----------------------------------------------------------ahlerrmiTAANASG-----A 288 
XP_002142650  355 -----------------------------------------------------------------kpVSIGSYA-----H 364 
7KMT_B        333 SSLEEILF-FLQA-------PTQTTLSLALINSIYDMLDYLVYDLMIPFMKRKVSFWEETILQpRKSLFNgaKFF---KK 401  brewer's yeast
7_pfamImport  301 PQAATGDPrGPEArapggprSHGACLTLKDHEHIRQFIQEFTFRGLLPHIEKNIRQLNDQLIS-RKGLSR--SLFtatKK 377 
XP_011612710  320 TATDGMNDaKGLEtrvggprSHGVCLTLNDHEHIRQFIQEFTFRGLLPHIEKNIRQLNDQLIS-RKGLSR--SLFtatKK 396 
XP_011471282  304 DADVMKAR-TDTEgvapvavGRGSCLTLNDHDRIRQFVQEFTFRGLLPHIEKNIRQLNDQLVS-RKGLSR--SLFtatKK 379 
5_pfamImport  317 KKGGRDPEsLVGAa-----gSHGACLTLNDHDHIRQFIQEFTFRGLLPHIEKNIRQLNDQLVS-RKGLSR--SLFtatKK 388 
XP_002065801  329 QNINPNVW-AASDdvaadnaPHGSCLGAKDLENLRHFVQDYAVRALIPYIEHLVAILSEGVTQ-KKGVSK--SLLsatKR 404 
XP_002896973  271 PHLSETFP-QVTE-------GMGTLLSRDDVAQIKTFVRDFGLRFMLSSLEGRIFQLNEVVSAmKKGV-K--NVF---KS 336 
Q57ZE9        316 PLLFPRVQaMFGKwpdgtakVTGCYLSPENVRDLRAVMHHYLSQCLFTFIERKLRSLNTTVNErRTTTLG--KMAa---- 389  Trypanosoma b...
XP_003064587  289 ITIDETVK-------------RGALLSKEDVAAHARVVKEYVAGSLLKSMEKRSRAANEKIAAtRKGLKN--QLKsfwGR 353 
XP_002142650  365 PYLDTTDY-YMNV---------NRFLTHSDMELLRSIIFSCVTKNFVLWIQNTMNRLYNTVNQsRKGIKS--HLRmfwRR 432 
7KMT_B        402 -------------FMNKNPvngnh------------qhnsLTRDSQGNE--------YFASSSSEFLMRKLADWSMMLSD 448  brewer's yeast
7_pfamImport  378 -------------WFGGGKape---------------kgaQEPRSTSGL--------LYPPEAPELQIRKMADLCFLVQH 421 
XP_011612710  397 -------------WFGGSKape---------------ksiSEPKSTCGL--------LYPPEAPELQIRKMADLCFLVQH 440 
XP_011471282  380 -------------WFGGGKape---------------kgmSEPKSACGL--------LYPPEAPELQIRKMADLCFLVQH 423 
5_pfamImport  389 -------------WFGGGKvpe---------------kgvSEPKSTCGL--------LYPPEAPELQIRKMADLCFLVQH 432 
XP_002065801  405 -------------WFVTSKp-------------------gAGANNQNAV--------IYTNESAELQTRKLGDLYFMFGH 444 
XP_002896973  337 -------------WLRKPkdl-----------------rpSNTSSSGGV--------LYKSDSIESQTRLLADTAFLVRD 378 
Q57ZE9        390 -------------WFRNKNevnks-----------kteswVAARGNSRA--------MYLAGSLEMQMRRAADLSLALAD 437  Trypanosoma b...
XP_003064587  354 -------------STG------------------------ASVKTEGDG--------AYTPASQESQIRVAADLAFFLGD 388 
XP_002142650  433 pkpevntsmnsdsFLSTLGmtnaisnlddksqlfesniplFTSYKDTSAkkqlrspiIYSASTIEGQTRILADLCFLIGD 512 
7KMT_B        449 FKTAYSTYESLMDDL--DAFPK-----YLASCIEWCAVSLLM----GAQSIVTVKMI----KNDINPLIERALATYENCs 513  brewer's yeast
7_pfamImport  422 YELAYSCYHTAKKDFlsDQAML-----YAAGALEMAAVAAFLq---P-------GAP----RPYPAHYMDTAIQTYRDTc 482 
XP_011612710  441 YELAYSCYHTAKKDFlsDQAML-----YAAGALEMAAVAAFLq---A-------GAA----RPYPTHYMDTAIQTYRDTc 501 
XP_011471282  424 YELAYSCYHTAKKDFlsDQALL-----YAAGALEMAAVSAFLq---G-------GGA----RPYPAHYMDTAIQKYRDDc 484 
5_pfamImport  433 YELAYSCYHTAKKDFlsDQAML-----YAAGALEMAAVSAFLq---A-------GAP----RPYPTHYMDTAIQTYRDVc 493 
XP_002065801  445 YNLAFQAYHQAKRDFnaDSAWQ-----YYAGALEMAALSAFQl-----------GTA----HRKTYDYMEDAIVCYLTVc 504 
XP_002896973  379 YELALQMYRLVRDDFksDKSVF-----HCANVNEMIAVCLLLt-----------KGS----PMQMTNALDAANAIYAKTp 438 
Q57ZE9        438 YDAAANFYRLCRAEAlaTVETRafnkpLIAAAQEGIGICHFLqgrlLPSSLTPWRAGgtssKNNSDCRLEVAMNDYDACe 517  Trypanosoma b...
XP_003064587  389 YETAASHYRLIQSDYkaDKAWK-----RLAATQEALGHALVMc---KPQQWAAEGPPfresRREAAAAFEAAAACYARAn 460 
XP_002142650  513 FSSATQYYKQILSDYklDKSYM-----CMGSTYEILAVCQVAt---GMDLEAVSNLL----LNACNSYQRSSDYYSYSLy 580 
7KMT_B        514 riqrgkgke----------------------------------------------------snsldvtepVRSYETRCMI 541  brewer's yeast
7_pfamImport  483 ---------------------------------------------------------------------kNMVLAERCAL 493 
XP_011612710  502 ---------------------------------------------------------------------kNMVLAERCAL 512 
XP_011471282  485 ---------------------------------------------------------------------rNMVLAERCAL 495 
5_pfamImport  494 ---------------------------------------------------------------------kNMVLAERCAL 504 
XP_002065801  505 ---------------------------------------------------------------------kLQQFATRATL 515 
XP_002896973  439 s-------------------------------------------------------------------plTQRMAIRTAV 451 
Q57ZE9        518 ----------------------------------------------------------------------MNVYSLRVAL 527  Trypanosoma b...
XP_003064587  461 vhaagggqtvappgtpppgggggggggggvpggtgtpgpafapptptpggvaavaavvappagafdsvaeRTLWATRAAY 540 
XP_002142650  581 mrsiifl--------------------------------------------------------vislfnsPDLYSVDSEF 604 
7KMT_B        542 LASELFLSLS 551  brewer's yeast
7_pfamImport  494 LSAEILKSQG 503 
XP_011612710  513 LSAEILKSQG 522 
XP_011471282  496 LSAEILKNQA 505 
5_pfamImport  505 LSAEILKSQA 514 
XP_002065801  516 LSMECLKTAR 525 
XP_002896973  452 IAGEIYHALS 461 
Q57ZE9        528 LLYEFCRTRT 537  Trypanosoma brucei
XP_003064587  541 AHAALLTACG 550 
XP_002142650  605 SISDLSGSFR 614 
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