Conserved Protein Domain Family
TRAPPC-Trs85

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pfam12739: TRAPPC-Trs85 
ER-Golgi trafficking TRAPP I complex 85 kDa subunit
This family is one of the subunits of the TRAPP Golgi trafficking complex. TRAPP subunits are found in two different sized complexes, TRAPP I and TRAPP II, and this Trs85 is in the smaller complex. TRAPP I, but Not TRAPP II, functions in ER-Golgi transport. Trs85p was reported to function in the cytosol-to-vacuole targeting pathway, suggesting a role for this subunit in autophagy as well as in secretion. The overall architecture of TRAPP I shows the other components to be Bet3p (TRAPPC3), Bet5p (TRAPPC1), Trs20p (TRAPPC2), Trs23p (TRAPPC4), Trs31p (TRAPPC5), Trs33p (TRAPPC6a and b) and Trs85p.
Statistics
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PSSM-Id: 403826
View PSSM: pfam12739
Aligned: 74 rows
Threshold Bit Score: 187.897
Threshold Setting Gi: 209558256
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCH61492      294 YDTAKEMLIKFKNIHSKTPNf------------PVYLNIn-DI---LPVFLLCYDASS----PEQLD--IAKKISTkIKK 351  Tetrapisispor...
XP_011471282  165 VEQFLKLSQEQHRIQHSGEYt-----------hPRWFIP--NT---LKYYVLLHDLSE----GDEQR--AETVYED-MKQ 221  Japanese medaka
EEN68410      119 MAEFTRLSQQQHELQHTSQAk-----------yPKWFTP--NT---YKYYVLLHDVAE----GDDSR--AEEVFKG-MKS 175  Florida lancelet
EFX86884      150 MEQFQQLNDQLTQLMSSNGTvd----------gPRWFNM--LS---LRYHVLIHDACD----GETSK--AEELLQT-MRN 207  common water ...
XP_002065801  160 VETAHKLTQRVQQMQSITPQk-----------lPKWFHPs-EV---LNSYVVLHEARQ----GDLSK--AQQAFEM-LKS 217  Drosophila wi...
EEY66454      176 RHSFEELTSPRNLP-------------------APFQMGlyDAtlvPKFFVVLHDVLE----TEGTSidPDAILRS---M 229  Phytophthora ...
EEA08301      255 ILDGLRTGISFTNIDGNSNYyhnqgyfrshylqETYLN---DF---PLVFILISDSSL----EDNCNldVQSIISK-LKQ 323  Cryptosporidi...
EEH51492      182 LGDATRMTEDGSSWPGGLPN-------------QPLLERagDVdvfARHYVLVHDARDatatRE-----AVAAKERiLAD 243  Micromonas pu...
Q57ZE9        179 VEGILKEFNELKRGQEIGEIwrnmp------------cmeeEM---HSHFLLLHDVTEgpgmDEVNR-----MFAA-VQS 237  Trypanosoma b...
XP_029285269  193 VEQFLKLSQEQHRIQHSGEYt-----------nPKWFIP--NT---LKYYVLLHDMSE----GGEQR--ADSVYED-MKQ 249  Cottoperca gobio
CCH61492      352 QLFFE-SILLPL-------------------------------------------------------------------- 362  Tetrapisispor...
XP_011471282  222 RYGSQgCYLLKInsravsaeedeqipdpwsqylhknnlr-------------------------------yqdpadgapa 270  Japanese medaka
EEN68410      176 SYGQNgCHLLKVnsrplnsakensaggpetmtgnlpdpwsqflnkkdv--------------ehdspdsgqsghstentd 241  Florida lancelet
EFX86884      208 AYGSHgCHLLVInskpkkgsmvepglpapdpwlrflprkasksdasiegetvvdgadagemelpgkvvegtnsqslgslp 287  common water ...
XP_002065801  218 TFGDSkCFLISInsneggqpaaqdmqdlwkdyikrqpkstlaqegs-----------------sdpsapkspqeatsavg 280  Drosophila wi...
EEY66454      230 NISTVnGAVLKInslpvesapvp--------------------------------------------------------- 252  Phytophthora ...
EEA08301      324 LFPENeFYLWNIkgiskcsc------------------------------------------------------------ 343  Cryptosporidi...
EEH51492      244 AFGDAkVSVLPVnssss--------------------------------------------------------------- 260  Micromonas pu...
Q57ZE9        238 SLGHAnCALVKLnsisnpqnvknmdpsvwtdanpsfmdvps---------------------------------dtacra 284  Trypanosoma b...
XP_029285269  250 RYGHQgCYLLKVnsrtfsaeedeqipdpwsqylhrntvqnqdv------------------------lddaavnsaaven 305  Cottoperca gobio
CCH61492      363 -----------------WNDKIYNND--KFVKLHEPMMSSV---------DETLyflq---------------------- 392  Tetrapisispor...
XP_011471282  271 aekggdeegggesgclnNDPL-QLEAdsSSTSLTDADVMKA---------RTDTeg------------------------ 316  Japanese medaka
EEN68410      242 tfpdkvtesepdqgvtaEVISHPLEQsdDEPELTNTDTMNQ---------LNEAa------------------------- 287  Florida lancelet
EFX86884      288 kmpimdalqeamqeiniNSILAPSPStsALSSLTRDESTNMknnlsqrsaVEIKddplnaglgmttsglsvdeadgtgli 367  common water ...
XP_002065801  281 smpamqmsvlqeqeqdvVGMLHPLSPmqESATDALSTRLSI---------SSESiasqninpn-------------vwaa 338  Drosophila wi...
EEY66454      253 ------sqfstvwtdnpYVRPPLFPHlsETFPQVTEGMGTL--------------------------------------- 287  Phytophthora ...
EEA08301      344 ----------sesifeeQKVDKPVSIgsYAHPYLDTTDYYM--------------------------------------- 374  Cryptosporidi...
EEH51492      261 ------------fssspHDDDIWTAHleRRMITAANASGAI---------TID--------------------------- 292  Micromonas pu...
Q57ZE9        285 vrysqqlesrsgspasaggggdSASSrvAAEPLLFPRVQAM---------FGKWp------------------------- 330  Trypanosoma b...
XP_029285269  306 nmsaaevdspekdsastSPESHPLQLdtASSSGSLHALTAA---------NTELkkaa---------------------- 354  Cottoperca gobio
CCH61492      393 -qylQKNSCVTDNKLPLSLVKYIYEMIANLSVNLIIPFMQRKIRFWDETiLQPRKSIfrNKLF------KSFMnrnsnvs 465  Tetrapisispor...
XP_011471282  317 ---vAPVAVGRGSCLTLNDHDRIRQFVQEFTFRGLLPHIEKNIRQLNDQlV-SRKGLs-RSLFta---tKKWFgggkape 388  Japanese medaka
EEN68410      288 ---rRKGNVPHGLYLTLSDHDRLRIFAHEFAVRGLLPHIERTIRTLNEQlA-SRKGLh-RSFFsa---tKKWFggnkqae 359  Florida lancelet
EFX86884      368 lapsIVESELHGGCLTTEDLDRIQGLVNDFCLKSLLPHMERQMRLLNESaS-ARKSTh-RSLLsa---tKRWFgssrpgg 442  common water ...
XP_002065801  339 sddvAADNAPHGSCLGAKDLENLRHFVQDYAVRALIPYIEHLVAILSEGvT-QKKGVs-KSLLsa---tKRWFvtskpga 413  Drosophila wi...
EEY66454      288 --------------LSRDDVAQIKTFVRDFGLRFMLSSLEGRIFQLNEVvSAMKKGV--KNVFkswlrkPKDLrpsnts- 350  Phytophthora ...
EEA08301      375 ---------NVNRFLTHSDMELLRSIIFSCVTKNFVLWIQNTMNRLYNTvNQSRKGIk-SHLRmfwrrpKPEVntsmnsd 444  Cryptosporidi...
EEH51492      293 ------ETVKRGALLSKEDVAAHARVVKEYVAGSLLKSMEKRSRAANEKiAATRKGLk-NQLKsfwgrstg--------- 356  Micromonas pu...
Q57ZE9        331 ----DGTAKVTGCYLSPENVRDLRAVMHHYLSQCLFTFIERKLRSLNTTvNERRTTTl-GKMAawfrnkNEvnksktes- 404  Trypanosoma b...
XP_029285269  355 repeVGVAGSHGACLTLNDHDHIRQFIQEFTFRGLLPHIEKNIRQLNDQlV-SRKGLs-RSLFta---tKKWFgggkape 429  Cottoperca gobio
CCH61492      466 sstgtssseis-------nsiskhhhslltkdsngHEy--------FSALSTEFQLRKLADWSMMVSDFKTAYTTYESLS 530  Tetrapisispor...
XP_011471282  389 kg-------------------------msepksacGLl--------YPPEAPELQIRKMADLCFLVQHYELAYSCYHTAK 435  Japanese medaka
EEN68410      360 kg-------------------------sgvqsnngGGi--------YSEASAEVQLRKLGDLCFLVQMYDLAYTSYHTAK 406  Florida lancelet
EFX86884      443 lq------------------------------------ttqtvavsYHPESVQLQLRRLGDLAFLLGHYELAYHSYHSAK 486  common water ...
XP_002065801  414 g-------------------------------------annqnaviYTNESAELQTRKLGDLYFMFGHYNLAFQAYHQAK 456  Drosophila wi...
EEY66454      351 ----------------------------------------ssggvlYKSDSIESQTRLLADTAFLVRDYELALQMYRLVR 390  Phytophthora ...
EEA08301      445 sflstlgmtnaisnlddksqlfesniplftsykdtSAkkqlrspiiYSASTIEGQTRILADLCFLIGDFSSATQYYKQIL 524  Cryptosporidi...
EEH51492      357 ---------------------------asvktegdGA---------YTPASQESQIRVAADLAFFLGDYETAASHYRLIQ 400  Micromonas pu...
Q57ZE9        405 ---------------------------wvaargnsRAm--------YLAGSLEMQMRRAADLSLALADYDAAANFYRLCR 449  Trypanosoma b...
XP_029285269  430 ks-------------------------vsepkstcGLl--------YPPEAPELQIRKMADLCLLVQHYELAYSCYHTAK 476  Cottoperca gobio
CCH61492      531 RDL--ENTSKYM-----ASCLEWWAVSILMGA--QNIVTAKmlk-------ndV-DPLIESALESYEKPLppvpnsrlps 593  Tetrapisispor...
XP_011471282  436 KDFlsDQALLYA-----AGALEMAAVSAFLQGg-GARPYPA---------------HYMDTAIQKYRDDC---------- 484  Japanese medaka
EEN68410      407 RDYtnDHAWMHA-----AGSLEMAALSVFMQGs-PQRQYPS---------------HYMDSAIQMYNQTC---------- 455  Florida lancelet
EFX86884      487 KDFeaDQAWLHY-----AGAMEMAALSVFLQNg-HNRTIPF---------------HYFDKALT---------------- 529  common water ...
XP_002065801  457 RDFnaDSAWQYY-----AGALEMAALSAFQLGtaHRKTY-----------------DYMEDAIVCYLTVC---------- 504  Drosophila wi...
EEY66454      391 DDFksDKSVFHC-----ANVNEMIAVCLLLTKgsPMQMTNA-----------------LDAANAIYAKTPs--------- 439  Phytophthora ...
EEA08301      525 SDYklDKSYMCM-----GSTYEILAVCQVATG--MDLEAVS---------------NLLLNACNSYQRSSdyysyslymr 582  Cryptosporidi...
EEH51492      401 SDYkaDKAWKRL-----AATQEALGHALVMCK--PQQWAAEgppfr---esrrEaAAAFEAAAACYARANvhaagggqtv 470  Micromonas pu...
Q57ZE9        450 AEAlaTVETRAFnkpliAAAQEGIGICHFLQG--RLLPssltpwraggtssknNsDCRLEVAMNDYDAC----------- 516  Trypanosoma b...
XP_029285269  477 KDFlsDQAMLYA-----AGALEMAAVSAFLQAg-APRPYPA---------------HYMDTAIQTYRDVC---------- 525  Cottoperca gobio
CCH61492      594 nninslnsr--------------------------------ssissatkaevsliennhTIRSYEIRCMLLLSELflsls 641  Tetrapisispor...
XP_011471282  485 -----------------------------------------------------------RNMVLAERCALLSAEIlkn-- 503  Japanese medaka
EEN68410      456 -----------------------------------------------------------KNPQFATRTTLLSTEIlks-- 474  Florida lancelet
EFX86884      530 -----------------------------------------------------------TMPYWATRCAVLASEClka-- 548  common water ...
XP_002065801  505 -----------------------------------------------------------KLQQFATRATLLSMEClkt-- 523  Drosophila wi...
EEY66454      440 ----------------------------------------------------------pLTQRMAIRTAVIAGEIyhals 461  Phytophthora ...
EEA08301      583 s------------------------------------------------iiflvislfnSPDLYSVDSEFSISDLsgsfr 614  Cryptosporidi...
EEH51492      471 appgtpppgggggggggggvpggtgtpgpafapptptpggvaavaavvappagafdsvaERTLWATRAAYAHAALltac- 549  Micromonas pu...
Q57ZE9        517 -----------------------------------------------------------EMNVYSLRVALLLYEFcrtrt 537  Trypanosoma b...
XP_029285269  526 -----------------------------------------------------------KNMVLAERCALLSAEIlks-- 544  Cottoperca gobio
CCH61492      642 d------------------twtstpYALRYLEtils--------dyklG----------------PCSQTILWERLsfcy 679  Tetrapisispor...
XP_011471282  504 ----------------------qakYSEAATLlikmt------------------------sedsdLRSALLLEQAahc- 536  Japanese medaka
EEN68410      475 ----------------------mnlFGDAAMQfikmt------------------------sedsdLRSALLLEQAahc- 507  Florida lancelet
EFX86884      549 ----------------------tnqYSDAALQlirlt------------------------sedadLRSAVLLEQAalcf 582  common water ...
XP_002065801  524 ----------------------arlYSEVAKQlirmt------------------------seesdLRSALLLEQAaycf 557  Drosophila wi...
EEY66454      462 k------------------sglftdYMDNASAalirg-------stmeQ----------------GICAAVLMERAalc- 499  Phytophthora ...
EEA08301      615 vkystiydsiidkvksviidmqnldMNSKYFSwilpndkgnysteynsTsrneqivrstniskqsILNFAIMNDLFtrll 694  Cryptosporidi...
EEH51492      550 ---------------------------------------------gsdReaaipltrasaeeaqtHARAALSLEAAata- 583  Micromonas pu...
Q57ZE9        538 p------------------------------------------plvdrTtalllhvqhrgmvgrsKLQIAVLQELLaana 575  Trypanosoma b...
XP_029285269  545 ----------------------qskYSEAATLlikmt------------------------sedsdLRSALLLEQAahc- 577  Cottoperca gobio
CCH61492      680 dlrvdprikrkptitninkgtkatgseashssikevnekyrndgkqekysidrknsliidvnsneeydcgydilsDGFTR 759  Tetrapisispor...
XP_011471282  537 ------------------------------------------------------------------------finMRSPM 544  Japanese medaka
EEN68410      508 ------------------------------------------------------------------------ftsMKMPM 515  Florida lancelet
EFX86884      583 lrsavkp----------------------------------------------------------nsssgdaakpNMVPL 604  common water ...
XP_002065801  558 -----------------------------------------------------------------------lispQPRAM 566  Drosophila wi...
EEY66454      500 ------------------------------------------------------------------------dlrARLPK 507  Phytophthora ...
EEA08301      695 all------------------------------------------------------------------pndahpSGSIS 708  Cryptosporidi...
EEH51492      584 ------------------------------------------------------------------------ylrADPPM 591  Micromonas pu...
Q57ZE9        576 lflnppqca------------------------------------------------------gmrikaslpnnfPVHAH 601  Trypanosoma b...
XP_029285269  578 ------------------------------------------------------------------------finMRNPM 585  Cottoperca gobio
CCH61492      760 KR-----KAAFFKLIAAKKWSEQKQWRQLDWCLKDIENVY-------------KEVGFSDRKDLIL 807  Tetrapisispora blattae CBS ...
XP_011471282  545 VR-----KFAFHMILAGHRFSKAGQRKHALRCYTQAMQVY-------------KDRGWSLAEDHIN 592  Japanese medaka
EEN68410      516 VR-----KYAFHMILAGHRFSKAGQRKHALRSYSQAMQIY-------------KGKSWTLAEDHIN 563  Florida lancelet
EFX86884      605 IR-----KYAFHMILAGHRFGKSGQKRHASRAYQLALQVY-------------KGHGWSLAEDHIH 652  common water flea
XP_002065801  567 HR-----KYAFHIVLAGNRYSRAGQRRHAYRCYRQAYQVF-------------EKREWSLAEDHIQ 614  Drosophila willistoni
EEY66454      508 FR-----KYGFRMVMAGHVYDSLGHEQHSARCYSLARAIY-------------DCSGWFLVEDHIN 555  Phytophthora infestans T30-4
EEA08301      709 RRnlychKWYYHSILAAQAFQYIGFKAISLQSFLNVLLQE-------------DTIKWPDIDTYLR 761  Cryptosporidium muris RN66
EEH51492      592 AR-----KYAIHAVLAGHRYNQAGLRANAIRCYAGALPVYerrrdagpgagkrRGVGWNKAREHLH 652  Micromonas pusilla CCMP1545
Q57ZE9        602 VR-----TYMKYCIAAGDAYCSEDMFQSALRCYLRALFVYgs---------vgRCGSWPHICEHLF 653  Trypanosoma brucei
XP_029285269  586 VR-----KFAFHMILAGHRFSKAGQRRHALRCYCQAMQVY-------------KERGWSLAEDHIN 633  Cottoperca gobio
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