8RAM,8FTK


Conserved Protein Domain Family
SEN1_N

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pfam12726: SEN1_N (This model is not part of the current CDD release)
SEN1 N terminal
This domain is found at the N terminal of the helicase SEN1. SEN1 is a Pol II termination factor for noncoding RNA genes. The N terminal of SEN1, unlike the C terminal, is not required for growth.
Statistics
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PSSM-Id: 520416
Aligned: 91 rows
Threshold Bit Score: 380.11
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8RAM_O         106 LKNHFNPILSVCDKCILNFARGKCKMLQHFAiQRHvPHEHVAKFNDIVCQWRVEAVF-----PILRNi----sVNDNTGI 176  brewer's yeast
18_pfamImport    1 WRDMFESLMHECPRCVTAFQHAKSEFINRYL-SLRkSEAAVRGFSDGIERLERDRVR-----QAFCDag--fgVDSTSAT 72  
XP_050201655    78 WKAQYSLCVNECVQCALGVEIAKTRARSIYM-SSF-PPDTLVNFFTLLEGWELSNVI-----SELCQrni-lnGQNVVAS 149 
ESK95021        84 WKEVLQGCLMNCSGCVLELEKVKITSRTTYF-GAF-TSNVLNNFWDQFNQWELQTVL-----ERLSS------LGVTLDS 150 
XP_007399310    79 WRAKLQACLAGCSQCVGRLPVIKDQSQRTYL-EKI-EHKTLQQFWDSFAVWELEIALkyceqSNLLPiatgtsSSSSDNS 156 
17_pfamImport    1 WRRYLRKCLAGCCACVRGFQEAKETSRHTYF-GAF-NDSVLKSFYDSLSNWELEAVI-----AGMADagi-tsPSVGADS 72  
7_pfamImport     1 WRQQFERVLVGCCECIRELQWAKLSSRHTYF-GCF-NDIILKDFYTNFDGWEKDVVL-----TELSKldr-ntDEARSPK 72  
2_pfamImport     1 WKKKFQVCLEGCSKCVKGFGEVKVSSRHTYF-GAF-SDSVIKNFYESFDAWELSMVI-----DALSRag--vnVQAPSNS 71  
XP_001835836    82 WKKHFHRCLSSCAFCVESLECIKISARSTYF-GAY-TKEILDTFFQKFEAWELTRVL-----ADLETrgfstaPISRNQG 154 
XP_001875791    82 WKEKLHACLSSCCSCVQKLEEAKVSSRQTYF-GAF-EHATVQAFFESFEGWELKMVT-----ADLSA----------ISL 144 
8RAM_O         177 NITNEIE---TAMYECLCNPHMLrLNKQLKATFEAIFKFFYDtKHrlldvtnPLSIktFISGVIFCWCEGSkeENEWSRA 253  brewer's yeast
18_pfamImport   73 AHLEDVA---PAAIQNCLVNHLLfQDTNIVNLIASGLPVSKPiQL-------PFE---VTPGLLGLRFHREraLRDWTQL 139 
XP_050201655   150 PTLYGVP---IGLTYRMVANLVVfRDPRIRAALEKCHASIPLdKW-------PTDP--LPAGMLALLVDENaaLREWAEE 217 
ESK95021       151 TSTSSIP---SPIAYRMVTNLPIfRDARIQSMIHKHLSLQQYsDW-------PSDP--IPPGVLALLMHDDqaVRRWASQ 218 
XP_007399310   157 ATLLNVP---PSIVLLMLSNLQIlRDPRTFSLIRTLSPDRPIsAW-------PLDS--PPAGLLLLLMDEDkgVRTWAYQ 224 
17_pfamImport   73 HALSIAP---PAITYHMFSNPYIlRDPRISKMVHYGLPEQIItSW-------PTDY--PPPCLFYLVVDERedIRKWALE 140 
7_pfamImport    73 SSLENAP---RTVLYHILSNLRIlQDPYVLEIVNQRVPQTLIkEW-------PIDV--PPPGLLLLLVAEKpeVRTWAQL 140 
2_pfamImport    72 HSLDRVP---STITYRMVSNMHIlRDKRVLPLIRSCPPTL---GW-------PTDP--PPPGLFPLMVDESaeVRQWAKN 136 
XP_001835836   155 RTLAEVP---PPLLYRILANWTVfTDSNVQAILHAFVPDSAVpDW-------PSNH--CPPGLIISMSDDSqkLREWACR 222 
XP_001875791   145 TSSKGLPnalAPLFYRIASNWTIfTDPNAFSILRQLALSGYAgDW-------PKDY--LAPGLFILLMDSNdkIRQWAQN 215 
8RAM_O         254 FLKDLYSRNFHINLSNLTPDIIEEVYIHILFlqnpan--------------------------wteivVSQFWSRLLPVF 307  brewer's yeast
18_pfamImport  140 QLDS-CELVTPRHYTHRGLGLIFGAHLKLLAsrdrgdfnae-----------------tvihlpyvesRVEFWQALTAVL 201 
XP_050201655   218 RYSALKHKPIPPDSLTFAHTSVAETIFRALAsdsasssqg-------------------epaapirsdIEVYWSGILKIV 278 
ESK95021       219 QATRAGVIPISNEILTPLFKDVVNSVVSSLMsnydgsnsa-------------------alvmttvkdPVMLWKSFHEFV 279 
XP_007399310   225 QVARYTTTPMPLECFIQSHVEVLVATVAAVSssnlnaepqs-----------------wspdfsfsrdPLILWSGYATML 287 
17_pfamImport  141 QLGSCKAAAMPADRFLQSHRAVLRTITSVVSnqagdsdat-------------------gigftfsqdSTILWSGYSVVL 201 
7_pfamImport   141 QISLFSTAPVPEKRFSPMHVSVLQGISTRIMsdspavtpdg-----------------savslpmtddATALWAGYLCVL 203 
2_pfamImport   137 QASKCKNVPILKDHFVPAHEIALDAVAGAFTsninsresqngsvniipssltsstssmnlqsfpyasnASDLWPGFCAIL 216 
XP_001835836   223 QLPSLELAIMSLEKFTPSYVKAFRALTAAIQsqsnpaspi--------------------stvqlssdPIILWSAFSTVL 282 
XP_001875791   216 HAAR-YFTPMPNGKFTGAYINVLEVIGRAMQmpkdslathlvaq------------spelapfsftpdLLQLWTGFRLFL 282 
8RAM_O         308 NLfdkdvfieyfqvpknveslkKTF-KFplePIFKMWYNHlSkSYhDKPLDFLLRGLTMFLNKFGSEFWSKIEPFtFHSI 386  brewer's yeast
18_pfamImport  202 ALldsetmhsqltraaslsnpgAPLtASavgDIIQVVAGHlG-DV-EDHFPDVLSCFRIIVDRLQENVWKSAADRfEEVT 279 
XP_050201655   279 ALmdpelllh---------------hlrlrvdIRRTVLGHlS-DN-GPHLHLVLNTFILLLGRLKEKIWQGEGPEyPQVI 341 
ESK95021       280 RFvhpdflv-----------------sngrndIRHFTTSHlH-DH-GPELEHILRCFILILKRLNDRLWSGETPEyPQVV 340 
XP_007399310   288 RFvppermga---------------niahkadLRKAIVTHlS-DT-GTHFFEVLKVFILLLPGLGPELWQGESENyPLHV 350 
17_pfamImport  202 RYvpseylrp---------------tksldvdIRRVVTSHlH-DT-GSNFVDVLRAFLLILSRIGPSVWEDEGTEfPQVI 264 
7_pfamImport   204 RYtpvpllna---------------ekaphldVSRIVASHlH-DT-GNHFINVLKSFCLMLSRIGPGVWAREGPEfPQAV 266 
2_pfamImport   217 RLipsdllvs---------------sshrnidLRRIITGHlH-DV-GPHFPEILRCLLFLLKRLGNGLWQGEGPEfPQVV 279 
XP_001835836   283 RLvpadwils---------------nrnqnldLRHLVTSHlH-DT-GPHLINVLKSLFFLFKRLGKNFWTGEAHDfPQVC 345 
XP_001875791   283 RFvpierlk----------------sshqqiSLWRIVSGHlH-DN-GPQFEEVLRSLLLVLKRMESTFWTGEGPEyPQIV 344 
8RAM_O         387 LDIIFNRDSFPIKLIKIQDNPIvehqtevyfqltgsvtdLLSWTLPFYHAL--SPSKRIQMVRKVSMaFLRIIANYPSLK 464  brewer's yeast
18_pfamImport  280 LHAILDNTSFERIFGGTHEDEPatn-----------depILNWIPPFLRSVaqSSTRFINSLAIIIAaFLGNLQALRFET 348 
XP_050201655   342 FDSIKDNPAYVEGMSKALSTSReaa------------gpYIKWYQPFLVTVe-PTPVYGEVIAKMAGlLCEELQHPRFQD 408 
ESK95021       341 FDALKDNPSFTSLIQIEASSLEkt-------------pwSLSWLSEYLYAIr-SQSVYPEVLAKITEyLCGELQHERFGD 406 
XP_007399310   351 FNIIKNNRFYASSLEPDRPEHGh---------------gSVQWIEAYVKSLg-ELPALRILIPPVIQyLCEELQHERYKD 414 
17_pfamImport  265 FSSIKDNVRYLEMLQSLADTRRdi--------------wVLSWVESYMKSIg-NSAICRDVLPIVIHfLCEELQHQRFQG 329 
7_pfamImport   267 FSSIKDNPRYLDVLQAISDPRKdv--------------wLLTWVETFLKAVg-DKPAFNDIFSSSIQfLCEGLQHERFQG 331 
2_pfamImport   280 FDAIKDNPSYCSLVQTVDVTTEkp--------------wYLSWFTEYLNSLr-ELPIFGDVLAKMVDfLCEELQHERFED 344 
XP_001835836   346 FDSMKDNQAFLELFHGKDRAR------------------ILPGISEFLYTLh-GTGAYGEVLAKAVDlLCRELQHERFAD 406 
XP_001875791   345 FDAIKDNPSFSHLLQRIDNSGErp--------------wFIAWFAEYLHTIr-DLDTYGEVFAKIVDfLCEEVQHERFQD 409 
8RAM_O         465 SI---PKACLMNSATALLRavltikeneRAMlYKND-EFETVLLTKtdsrallnnPLIQDIiIRS---ASNPndfYpglg 537  brewer's yeast
18_pfamImport  349 AArtrAITIAATILSDVFL---------DTDgLIDAqSKWPHAREAaki---ldlHAPTIAdFAFdprFGAE---H---- 409 
XP_050201655   409 -SapaTIAIAAQILEKLVRr-----------------HSQTHAAAVasa---idiHVAKLSqVAFapsFNND---K---- 460 
ESK95021       407 -ArptIMLYATKLLKSQVK---------------------NQSSTVadl---mdiHADMFTaVLFaasHSEA---R---- 454 
XP_007399310   415 -LrasAVCVAAKLLDTFLA----------KAsQDLSaEISPLLSAVlep---ldiHANVFTsVAFgksYVGD---V---- 473 
17_pfamImport  330 -IrpvAISTAAKIIKAVLT-------------QTEKgKSVVPSSLVwei---mdvHSSTFVaISFtkaFAGD---A---- 385 
7_pfamImport   332 -LrpaAMTILFILSSSGNP---------------QDeQSAARDLLVsev---mniHASTIVsVAFgkaHADE---R---- 385 
2_pfamImport   345 -ArpmAMLAAVRLLANLLR---------KVSnEAANeNTTKLRVAVssv---ldiHAEVFIsVAFgrsFMDV---K---- 404 
XP_001835836   407 -ArppIMAAGVRLLTSVIE-------------RSGKdKEARYDDDLrnt---ldiHGLALVgVAYgrsHTSN---D---- 462 
XP_001875791   410 -ArpvIMDSVLCLLSSVFH-------------KFQSdKSFRHRRAVldt---ldiHSGVIVgVAYspdYNSE---K---- 465 
8RAM_O         538 aaSASVATSTMMVLAECIDFDILLLCHRTFKLYSGKPis-----------eiPISTn----------------vLENVTN 590  brewer's yeast
18_pfamImport  410 --WRKATSTARELTMRIMQRDARRVRDAIHTLGSYSMelkraedqakrskkdVLVTfesetstahgppppivayCAPLWK 487 
XP_050201655   461 --WALARKTSRSLLFSAVKVDARTVLAAFDGVYHALAevsrkipvktvivkhTS--------------------REMLWK 518 
ESK95021       455 --WSNARGATRDLVHQALVRDTVNISDAITRLCRWQAylelkkkqpeieekeKAPFr----------------iREQIWK 516 
XP_007399310   474 --WAEARCVARSLIRTSLRMDVGLIFGTIRCLAATSSntksv---------------------------asstiHEQIWR 524 
17_pfamImport  386 --WTEARAFMRKLLNVALMEDIKTISSAISYLHGTTTetlst----------------------------pvtlREQLWK 435 
7_pfamImport   386 --WTEARAFTRKLVKQILQGDVKGVMRSISQVCTSQAtmsg------------------------------pkiHKQMWR 433 
2_pfamImport   405 --WINARVSARELITSALLQDVQDVSSAIHVCCKQLAgyatap--------------------------picnvRKEMWK 456 
XP_001835836   463 --WAETRKSARHLFNLIFGRDSTRILSTVDRVCDIMNgvlpqsegpsipapaI---------------------CSSLWK 519 
XP_001875791   466 --WKKLRMSARTLVTSALVSDIQDISTAISGLCLLLAqkkggkiaegrtdgtEKLGls---------------iRKPVWS 528 
8RAM_O         591 KIDLRSFHDGpLLA-KQLLVSLKNINGLLIVP------------------SNTAVAEAHNALNQKFLLLSTRLMEKFAD- 650  brewer's yeast
18_pfamImport  488 RSYEIVRSTD-ARNlAAIVQGTSACYHLEHLTartw----------iykdQIRAQMKAVNAALDQIRLPLISLVESFTD- 555 
XP_050201655   519 TICQAVDSRD-QDAfAELLTIAYEIAHVDIPTkkayqevft-atrptdsaSPKVALEDVSRSLQVMHDCISGALGRYVEd 596 
ESK95021       517 KMYSAFQSGD-LDGlRSILSIVAQAAHLDYLSenslsqi-----lkvklqGVKELIQAVNQALTVIRTGFLDAITKFTDy 590 
XP_007399310   525 RMYELVLPDD-SDGiAMIITVLSDIAHVDDLHegafgaif---gnntnkdDFMKAVHGVNLALEVMRTGFSDSVSRYLDf 600 
17_pfamImport  436 GMYNSIQPGD-TDAmAMMLTVLSNIAHMDDLKeaafadri---arspdagSLKTLLSSVNRAFGIMRTGSGEAVTRYLDl 511 
7_pfamImport   434 RFYDSIQPGD-TDGmVMVIGSIAQVAHVDDLKetafsatf---rkaehpaGLRSILRGINESLAVFRSGFADATSRYLDl 509 
2_pfamImport   457 RVYGTLQTND-GDGvVAMITVVSQTSHLDTFNkdvylri----qkkpldsATDQAIDAINRSLVVMRDGFLDVLSKFANy 531 
XP_001835836   520 EVHSAIQARD-DTAiANVVLASAQTSHLSVLTktsyhkierveahgqgtiAGAEAIDSINAALAGTRSGFLDAISRFTNs 598 
XP_001875791   529 QLFSSIQTRD-TSGiASIICIVAKSAHLDVVNkstfkdilk-mskdeehqSVERALDEVNTSLKITHDGFLHAISRFADy 606 
8RAM_O         651 IlPGQLSKILADEDASQGFWSCIFSSDKHLYQAATNILYNTFDVEGRLEGILAILNSNLTVNLKNINVMLQRLINCEF-- 728  brewer's yeast
18_pfamImport  556 EaPAALLDFLARPGITENFVVWALSPIEQMHNVAQGVVKQAYDVLTRRDCLGALLLHHPGAALRGLLRSLRSFTTTANfl 635 
XP_050201655   597 NsASAALGLLRRESITQRVVSLMMSPVEVLHTGAKDLVGVAFDVDVRSECFRALFKELPDPAFSGALRHLEMFMSFVNkp 676 
ESK95021       591 NvPTATLDVLQRDGTVKDVVRLMLSPVDVIRNGAQMLIGHAFDVDIRADCYRALIGKFPGHALDGMFEFLTTFVSYAStv 670 
XP_007399310   601 TePRDALAFLRQYHIVGQVTTIMFSPVAVLRQPVQSLIGFALDAESRADCFRALLELDPDRVFEGMYRALQNFTKSTTtm 680 
17_pfamImport  512 SlPSVIAELLRRADVAKNVTILMLSPVEVLQESAQSLAGLAFDVEVRSDCFRALLEKVPTPTFAGVMHSLETFIQYAPtv 591 
7_pfamImport   510 SlTSDVTDLLGRPEVVENLMLLMLSPVDTIQETGQALAGAAFDVEVRIDCLRVLLEKYPHNAMSGLFKFLRTYIEYTRvv 589 
2_pfamImport   532 NlSSFILDILRRPGVVNNVMVLMLSPIDDIQAAAQTLVGQAFDVDVRLDCFRVLIENLPDPSLGGIFDFLENFNRYAPlv 611 
XP_001835836   599 SlSTTAMNLLAKPEVGRAVISLLLSPMPDCQTAAQSIIGLAFDVDVRMDCFRAMFSNLPIITFEGLTDFLTTFQEHANkv 678 
XP_001875791   607 GiSSSALEVLLCPGVGKAVTLLLLSPIADFQVAAQTLVGLAFDVDIRLDCFRALLENIPDVTFDGITEFLSIFREYAIkv 686 
8RAM_O         729 ---YEPCPRAVRVLMDVVSAFVDPISGVFANFQTlks-----qnTEKEFLKFWESCWLFLDTIYKFTLKWASKYDYSELE 800  brewer's yeast
18_pfamImport  636 peaCGQAKRLVRCLSDVIDVLCATANGLLRNASFlrrgveeeehLGSRLFELWRRMCGALALVFKETPSWSTFFENSVMT 715 
XP_050201655   677 peaCSLAKMLVRCFTDIIEVLCESPGGLLRSTSYapas---shsLRRDIPKLWEGMAGSLKYIFRRTPTWARWFENDAMT 753 
ESK95021       671 peaCSLAKSLVRCFTDILEALCASPDGHLHKPQFlqsl--haggLHTKLVALWKSMCKAMNVIFKRTPQWSPLFTPNVMI 748 
XP_007399310   681 peaCNLSKALALCLTDVIDVLSSSSDGLLHRTNFlqsf--kqagPEVQLPKWWSLMCQALTHIFQRTPRWADYFENGMMV 758 
17_pfamImport  592 peaCSLSKALARCLTDVIDVLCSSPDGLLLKRELltkg--agadVPTLLPKWWNMMTQALSVIFAKTPKWAVYFENAEMV 669 
7_pfamImport   590 peaCSLSQALARCLTDVIDVLCSSPDGLLLNIGFlksg--pgskLPDLLPKWWNMMTQALSAIFKWTPRWAVHFDNEEMV 667 
2_pfamImport   612 peaCSLSRSLVRCFTDIIEVLCSSPDGLLHNDKFlkpv--dkqgPAAQLPRLWSLMVQSITVIFKRTPVWSGHLHVDDMV 689 
XP_001835836   679 peaCTLSTSLVRCFNDVLEVLCSSPDGLLLSKTFlrpg--dpqgPASRLLSFWKLLTTCITTIFKHTPVWSSFYKAKEMT 756 
XP_001875791   687 peaCSLSQSLVRCFTDIIEALCASPNGLLLNVHFlrpt--dgegPASRIPQLWHLMTKALTVIFKRTPNWSVYFENQDMI 764 
8RAM_O         801 NFTKDTLDLSRSLVDSFREFSDILHDQT---------------------KNLLLNVLETFKNMLYWLRLSDEVLLESC 857  brewer's yeast
18_pfamImport  716 EWMRDAILFGVDLLEQQHAFEIAIRDTLrsgtnpas-----tkqastqaRHVIAALSEPLEELTSWLRLNDEDLLSAT 788 
XP_050201655   754 EWMRDALIFGRDMIAQRETFEGAAAADKdakttdkeakaadrkfkakigQKMLQDMQPVLLDLTKWLRLTDEELLHQT 831 
ESK95021       749 EWMRDALIFERDLLAHRTILETAVNTPSggrhvsdp------rnpsatgKRMIQDLHETLPELTRWLRLTDSELLHQS 820 
XP_007399310   759 TWMRDALIFGRDMLAQRKLIESGALALSpqslanr--------gkshigSKMVDGLQAVLLELTRWLRLTDEELLFQA 828 
17_pfamImport  670 LWMRDALIFGRDMLAQRRVIESASLVHSgqtavsg--------kmsrvgRRMVDDLQTVLFELTRWLRLTDEELLHQS 739 
7_pfamImport   668 LWMRDALIFGRDMLAQWRVIESGALAHRqessarr--------klsetaKKMIGDLQQVLLELARWLRLTDEELLHQS 737 
2_pfamImport   690 FWMRDALIFGRDMLAQWRVIESAAAASDksslrd---------glsrvgKKMLNDLQEVIPELARWLRLTDQELLHQS 758 
XP_001835836   757 VWMRDALILGRDIVGQWRLVESAINSDSakpskg----------lshagKEIVACFKAMLPQFFKWLRLTDEELLYQS 824 
XP_001875791   765 VWMRDALIFGRDMLSQWRVIENATLSSQqaltnqrl-----sgkpskvgERMVNDLQDVLTELARWLRLTDEELLHQS 837 
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