7DA4,6JPD


Conserved Protein Domain Family
RHIM
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pfam12721: RHIM (This model is not part of the current CDD release)
RIP homotypic interaction motif
RIP proteins are receptor-interacting serine/threonine-protein kinases or cell death proteins. This interacting domain is involved in virus recognition. The RHIM domain is necessary for the recruitment of RIP and RIP3 by the IFN-inducible protein DNA-dependent activator of IRFs (DAI), also known as DLM-1 or Z-DNA binding protein (ZBP1). Both the RIP kinases contribute to DAI-induced NF-kappaB activation. RIP3 undergoes auto phosphorylation on binding to DAI.
Links
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Statistics
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PSSM-Id: 520412
Aligned: 24 rows
Threshold Bit Score: 24.6281
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7DA4_B         63 PLVNIYNCSGVQVGDNNYLTM 83   human
9_pfamImport    2 WPLIIQNANGIQIGSNNQMNF 22  
5_pfamImport    2 GFLSINNCQGVQFGNNNHMVM 22  
Q80UF7        678 QPLIIHHAQMVQLGVNNHMWG 698  house mouse
XP_014978020  676 QPLIIHHAQMVQLGLNNHMWN 696 
Q9Z2P5        438 QSIVLNNCSEVQIGQHNCMSV 458  Norway rat
Q06A28         51 YVRIMNGVSGIQIGNHNAMSI 71   Murine cytomegalovirus (strain Smith)
7_pfamImport    2 RDIYMLHCKQVQLGHHNKMSL 22  
NP_067369     182 SHISIANSNAIQIGHGNVIVR 202 
EGV93716      639 GPLIIHHAQMVQLGVNNHMWG 659
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