5OQR


Conserved Protein Domain Family
Cnd3

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pfam12719: Cnd3 
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Nuclear condensing complex subunits, C-term domain
The Cnd1-3 proteins are the three non-SMC (structural maintenance of chromosomes) proteins that go to make up the mitotic condensation complex along with the two SMC protein families, XCAP-C and XCAP-E, (or in the case of fission yeast, Cut3 and Cut14). The five-member complex seems to be conserved from yeasts to vertebrates. This domain is the C-terminal, cysteine-rich domain of Cnd3. The complex shuttles between the nucleus, during mitosis, and the cytoplasm during the rest of the cycle. Thus this family is made up of the C-termini of XCAP-Gs, Ycg1 and Ycs5 members.
Statistics
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PSSM-Id: 403809
View PSSM: pfam12719
Aligned: 122 rows
Threshold Bit Score: 105.385
Threshold Setting Gi: 154341302
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5OQR_B            461 RCLSYVQCLFENITSs---lNENLYMVDMLKTLIIPAVRSH-DLPIREKGLECLSLVCLLNA--DLAFENVPLYL-HCYE 533  Schizosac...
EED95860          601 RVIAILSIVLENISg----rMVGHPILDGFFEHLSPAITSK-NAVIREHGVVCLSKFCLLTEedKVMGQFKPLLM-TIAG 674  Thalassio...
XP_002183659      546 RILAILSLVLERVSpg---fGSNPDALTSWATHIIPAVTSE-NLLIRQLGVSCFGKLGLFTPvdTISEQFLPLIL-RMAS 620  Phaeodact...
jgi:MICPUN_61425  507 QALFLASLVLEECPrh---vVNGDVVEALMATLVRPGVTSA-SAAVRREAVRCLGLVGIVFGv-RDDGECVRVLR-AALC 580  Micromona...
XP_001421348      475 QALYIAGSLLERTSk----rLPSVAAEAVMDSLIKPAVTHS-TTAVRRESMRVLGLLLASQG--VINPDAVVILR-TALS 546  Ostreococ...
EFJ32042          515 QCLATTGILLENLRSirqfpAHVMETQEMVDGLLIPAANHL-VADVRRAGVRCLSLYCLSEE--HPSVRVIRQLE-EALI 590  Selaginel...
EEE65468          423 HCLAVTGLLLENASSlqslqGKAIEPLELLQSLLLPATKQN-HDDVQRVALRCLCLFGLLEN--RPNAELVKQLR-LSFI 498  Japanese ...
AQL02920          524 HCLAVTGLLLQNTSTlrnlqATAIEPSELLHSLLLPAAKQN-HVDVQRAALRCLCLLGLLEN--RPNAELVKQLR-LSFI 599  Zea mays
XP_001566604      546 RMQLIVLEFLSHSQ--------RGDAIPMFCYHIIQMGRHLdNESVRVAAIKSLCLQCLINP--ESVHTFIPLILaDSHE 615  Leishmani...
XP_018686806      373 HCLALTGLLLENIPSlwslqGKAIEPSELLHSLLLPGAKHS-HIDVQRVATRCLSLFGILER--RPTGELVSQLR-QSFI 448  wild Mala...
5OQR_B            534 ----Kg-sVV-----LKCTAIRTLTDMLIQHGKAKFtey----------------------------------------- 562  Schizosac...
EED95860          675 sveeRv---E-----VRAQAALALCDMALLHDKtlessdve----------------------------------gedds 712  Thalassio...
XP_002183659      621 neveTd---E-----IRAQALLALSDWATLFPVvlktqe-------------------------------------ldgk 655  Phaeodact...
jgi:MICPUN_61425  581 gd-----cPA-----VRAVAARALGDLSLLYGVQALdahnpsrdecepaqaalaapletalldavdeeygdaavaekgte 650  Micromona...
XP_001421348      547 ad-----aAP-----VRCMAARALGDAALLHGPAALdkyrvlvdpededvtesafn-------aslpleialmkcldeeg 609  Ostreococ...
EFJ32042          591 ----Ks-yGA-----EKIMAIKGMFDLVMSHGAGLMdsqrash--------------------------------spgqm 628  Selaginel...
EEE65468          499 ----Ng-pDL-----VSAMACKALIDLVTWHGPQEIdqtigiessdatneksq-------------fttvdvsnmndddl 555  Japanese ...
AQL02920          600 ----Ng-pDL-----VSAIACKALIDLVTWHGPQEIdraigiespdpsyeksq-------------ftqvdlsdmndddl 656  Zea mays
XP_001566604      616 naaaKtacPEgtgmsLPIAAIGVIFDLIMEYGLRFFdvekqppketravynaeseie-----arlqheqklaeedvhkvg 690  Leishmani...
XP_018686806      449 ----Dg-aTS-----VRIMASKSLIDLFTWHGPQEVdkaigidikqpnneke--------------glvsinssnlrdde 504  wild Mala...
5OQR_B            563 edAISSILFEALg--EFe-------------nAELQTLGAEAIAKLLVILHY------RDE--L-FLKPLIIQYFEPN-- 616  Schizosac...
EED95860          713 tlSFKDMLLEMLgh----------------skPGIVIIAAEITAKLLLAGRF------HDP--N-LVAWLLTVFFDTSl- 766  Thalassio...
XP_002183659      656 mvSISDVVHYWLdnlpk----------gsgnhTSLAFIAAEVATKLLWSGRI------VDS--S-WLANLVVIFFDPNls 716  Phaeodact...
jgi:MICPUN_61425  651 deEAVD---------EAdmltggaaaaeaerdASVATAAGEALAKLILRRGAravadpAA-----VVARLVRCYFNVD-- 714  Micromona...
XP_001421348      610 kpFVFKANAYDLedvDVedvdatkaaaaveaeESVGTVAAESLCKIILRRGEgafeaaAA-----VVSRLLGSYFAAD-- 682  Ostreococ...
EFJ32042          629 qlPLLQLLADILs--DQhdiyvq---edigetESARSVAAEGFAKLLLHSKRfp--elGLVr-SrVLSDLFRMYFDED-- 698  Selaginel...
EEE65468          556 niGVLDILFSGF---LKddwefn---legdnhDNVPTILGEGFAKILLLSENya--riSADlhPiILARLVSLYFMEE-- 625  Japanese ...
AQL02920          657 niGVLDILFSGF---HKdhwefd---legdnhDNVPTILGEGFAKILLLSGNfa--siPADlhTvILAKLIKLYFSEE-- 726  Zea mays
XP_001566604      691 skRLLATLQSYLqpgS----------------EAKHTITASGFCKLLSCNRLpve-vvSH-----VITVLLIHYAGAMas 748  Leishmani...
XP_018686806      505 siGLLDLLYNGL---NSddsgev---gdadddESVHSILGEGFAKILLLSENyp--siSTClsPlILHKLVNLYFCDE-- 574  wild Mala...
5OQR_B            617 TVD-------------NH--ALRQVLGYFFPVYAFGAH--En-qWRIATI--FCDALLS----LLEIYRDLded-----d 667  Schizosac...
EED95860          767 TENhdaeengaevkevGSpvRLQQLLSIFFPTYSMSHL--DandAVMASVgpLLSIINEk---LGGAKSAKal------- 834  Thalassio...
XP_002183659      717 TGEmeeeyheeeskeiGSlvRWQQLQSVFFPAYVRRGP--Vy-qEALLNS--ISHILQV----FSSRSQKTtr------g 781  Phaeodact...
jgi:MICPUN_61425  715 ARR-------------RP--RMAQCLAVFFPAIASAPAdrR---ALVAES--SLFALRTsa------------------- 755  Micromona...
XP_001421348      683 AQR-------------RP--RLAQCLAVFFPALASGPEdrR---RLLADC--ALPALRAaa------------------- 723  Ostreococ...
EFJ32042          699 TKS-------------IP--RLGQCLSVFFHNYASATPehK---RCIAEV--FVPVLRKewpgLTGSACNShiaai-rkk 757  Selaginel...
EEE65468          626 TKE-------------LK--RLKQCLSVFFQHYPALSDkhK---RCVSSA--FVPVMRAmwpgLYGNVGGSahavskrrk 685  Japanese ...
AQL02920          727 TKE-------------LE--RLKQCMSVFFQHYPALSDkhK---SCICNA--FVPVMKAmwpgLYGNAGGSthviskrrk 786  Zea mays
XP_001566604      749 KKEs------------TTaaYMVDYLGTFFRSYAASHP--Kr-qVQLCEG--GITAFRV----VLERN------------ 795  Leishmani...
XP_018686806      575 TKE-------------LQ--RLKQCLSIFFEHYPALSCthKr---CISTA--FIPTMRSlwpgVYGKSGGPaitvsklrk 634  wild Mala...
5OQR_B            668 vQLSIGHIAQQML------DWT-----D-NEKLYERKTQTgddy-----------ialnHNVHLHLANMIFESLPNASEg 724  Schizosac...
EED95860          835 nKWPITKIVEFICyt---vDLA-----DkKKNAEVETENDependrlae--ptevgplsKSSSDK--------------- 889  Thalassio...
XP_002183659      782 kSLPVVKMIDFVC------ALV-----E---EGVAKADSTksateldna--kdeecmalTSVGLSSAVQIATFLYASHDn 845  Phaeodact...
jgi:MICPUN_61425  756 kDKGVAKVASYLA------HLL-----A-CNTQEVEEKEEkdgviqtttksvvapavggAALVAELAKEALAVTFRPAPt 823  Micromona...
XP_001421348      724 kIKGLSRVAALLV------QLLtasee---------------------------ptaggAELALALANESLALSTKQTPs 770  Ostreococ...
EFJ32042          758 nASHLSRFMLELLkqplfsQQNpdesaDf------------------------------AILAIDLAREIMRFSSRKTLa 807  Selaginel...
EEE65468          686 yAAQAARFMVQMVqtplfsTET-----T-----EQASSSPesqstkpdm--lnnfdiseEGLAIRIAVEVANCPDKKTAa 753  Japanese ...
AQL02920          787 lAVQASRFMVQMVqtqlfsTES-----M-----DQASKSSesasglada--snnfdiseEGLAIRIALEVASCPDKKTAa 854  Zea mays
XP_001566604      796 -IVMASKLIEFVArlsdayTLTvirdiD-PQAAKRATRDVvdetadv-----------aeeeeaqRKSNRINATRSSMQ- 861  Leishmani...
XP_018686806      635 rAVLAAHFMLQMMqiplfsNER-----K-EDELSSGNlsssvqts-------ddfdsgeEGIAIRIAAEVAGCPEKKTSa 701  wild Mala...
5OQR_B            725 -K-------E-RKFMISLLGKLKI 739  Schizosaccharomyces pombe 972h-
EED95860          890 -K-------EvIEASSTLLASIDI 905  Thalassiosira pseudonana CCMP1335
XP_002183659      846 ln------aagLRALCKYLGNIKL 863  Phaeodactylum tricornutum CCAP 1055/1
jgi:MICPUN_61425  824 aaaekqltkayVAALAKLAAAVPL 847  Micromonas commoda
XP_001421348      771 gaqap-lakayTNAIARVLSVVPV 793  Ostreococcus lucimarinus CCE9901
EFJ32042          808 vK-------AyKSALCKVLVSLKF 824  Selaginella moellendorffii
EEE65468          754 aK-------AyCLALCKVAVLLRF 770  Japanese rice
AQL02920          855 gK-------AyALALCKVVVLLRF 871  Zea mays
XP_001566604      862 -----------SGRLFRELSRYSL 874  Leishmania braziliensis MHOM/BR/75/M2904
XP_018686806      702 gK-------SyILALCRIAASINF 718  wild Malaysian banana
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