6IGX,5OQR


Conserved Protein Domain Family
Cnd3

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pfam12719: Cnd3 (This model is not part of the current CDD release)
Nuclear condensing complex subunits, C-term domain
The Cnd1-3 proteins are the three non-SMC (structural maintenance of chromosomes) proteins that go to make up the mitotic condensation complex along with the two SMC protein families, XCAP-C and XCAP-E, (or in the case of fission yeast, Cut3 and Cut14). The five-member complex seems to be conserved from yeasts to vertebrates. This domain is the C-terminal, cysteine-rich domain of Cnd3. The complex shuttles between the nucleus, during mitosis, and the cytoplasm during the rest of the cycle. Thus this family is made up of the C-termini of XCAP-Gs, Ycg1 and Ycs5 members.
Statistics
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PSSM-Id: 520410
Aligned: 116 rows
Threshold Bit Score: 111.948
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6IGX_B        498 KCLILCYELLKQMSi---STGLSATMNGIIESLILPGIISIHPVVRNLAVLCLGCCGLQNQ--DFARKHFVLLLQVLQ-- 570  human
XP_002286219  601 RVIAILSIVLENIS----GRMVGHPILDGFFEHLSPAITSKNAVIREHGVVCLSKFCLLTEedKVMGQFKPLLMTIAGsv 676 
XP_002183659  546 RILAILSLVLERVSp---GFGSNPDALTSWATHIIPAVTSENLLIRQLGVSCFGKLGLFTPvdTISEQFLPLILRMASne 622 
XP_002504647  507 QALFLASLVLEECPr---HVVNGDVVEALMATLVRPGVTSASAAVRREAVRCLGLVGIVFGv-RDDGECVRVLRAALCg- 581 
XP_001421348  475 QALYIAGSLLERTS----KRLPSVAAEAVMDSLIKPAVTHSTTAVRRESMRVLGLLLASQG--VINPDAVVILRTALSa- 547 
EFJ32042      515 QCLATTGILLENLRsirqFPAHVMETQEMVDGLLIPAANHLVADVRRAGVRCLSLYCLSEE--HPSVRVIRQLEEALI-- 590 
XP_006828429  516 HCLAVTGLLLENIKsfksLRGKPIEASEILHSLLLPAAKHIHMDVRRVAVRCLGLFGLAEG--KPSHEMVKQLRISFI-- 591 
NP_001348364  524 HCLAVTGLLLQNTStlrnLQATAIEPSELLHSLLLPAAKQNHVDVQRAALRCLCLLGLLEN--RPNAELVKQLRLSFI-- 599 
NP_198579     542 HMLSLTSLLLENGKslhsLQGKAIEPEEILHALLLPGAKHTHLDVQRIAIKGLGLFGLLEK--KPSEELVRQLRAAFC-- 617 
XP_003552880  584 HCLSLTGLLLKNAKslrfLQGKAIGPDELLQSLLLPGAKQSHLDVQRIAIRCLGLFGLLER--KPSAELLKQLRISYI-- 659 
6IGX_B        571 --IdDVTIKISALKAIFDQLMTFGIEPFKTKKiktlhcegtEINSD--DEQ-ESkeve---------------------- 623  human
XP_002286219  677 eeRv--EVRAQAALALCDMALLHDK---------------------------TLessdv--------------------e 707 
XP_002183659  623 veTd--EIRAQALLALSDWATLFPV---------------------------VLktqe---------------------- 651 
XP_002504647  582 ---dCPAVRAVAARALGDLSLLYGVQALDAHN-------------PsrDECePAqaalaapletalldavdeeygdaava 645 
XP_001421348  548 ---dAAPVRCMAARALGDAALLHGPAALDKYR---------VLVDPedEDVtESafnaslplei-----------almkc 604 
EFJ32042      591 --KsYGAEKIMAIKGMFDLVMSHGAGLMDSQR---------ASHSPgqMQL----------------------------- 630 
XP_006828429  592 --NgPSSVSIIAGKALFDLAMWHSPEEVDRAV---------GLGLs-tPSPdDNgispsgn----------------scd 643 
NP_001348364  600 --NgPDLVSAIACKALIDLVTWHGPQEIDRAI---------GIESp-dPSYeKSqftqvdl----------------sdm 651 
NP_198579     618 --RsPPPISIMACKALVDLGMWHSPTEVDKAM---------GQDLLsqFEDdSIdfapidl-----------------sn 669 
XP_003552880  660 --KgPHSISIEACKALIDLVMWYGPQEVDKML---------NLSIPcqLNSeKTtfspvnf-----------------sd 711 
6IGX_B        624 -etaTAKNVLKLLSDFLd--SE-V-------------SELRTGAAEGLAKLMFSGLL------VSS--R-ILSRLILLWY 677  human
XP_002286219  708 geddSTLSFKDMLLEMLgh----------------skPGIVIIAAEITAKLLLAGRF------HDP--N-LVAWLLTVFF 762 
XP_002183659  652 -ldgKMVSISDVVHYWLdnlpk----------gsgnhTSLAFIAAEVATKLLWSGRI------VDS--S-WLANLVVIFF 711 
XP_002504647  646 ekgtEDEEAVD---------EAdMltggaaaaeaerdASVATAAGEALAKLILRRGAravadpAA-----VVARLVRCYF 711 
XP_001421348  605 ldeeGKPFVFKANAYDLedvDVeDvdatkaaaaveaeESVGTVAAESLCKIILRRGEgafeaaAA-----VVSRLLGSYF 679 
EFJ32042      631 -------PLLQLLADILs--DQhDiyvqe---digetESARSVAAEGFAKLLLHSKRfp--elGLVr-SrVLSDLFRMYF 695 
XP_006828429  644 gdddLGLGVVDLLYSGF---DReQwdncs---dagdhQTVRAVLAEGFAKMLLQSKNyp--siSSSmhPlIFGKLIKLYF 715 
NP_001348364  652 ndddLNIGVLDILFSGF---HKdHwefdl---egdnhDNVPTILGEGFAKILLLSGNfa--siPADlhTvILAKLIKLYF 723 
NP_198579     670 aeedMNFKMLDLLYAGL---ESdDwrast---essenESVKATVGEGFAKLLLLGEKyp--nlPASfyPfVLGKLIALYF 741 
XP_003552880  712 sereLDVGTLDILYGGF---ENdDwaspl---psnedECVHAILGEGFAKILLLSNNyp--siPASlhPvILSKLIYLYF 783 
6IGX_B        678 NPV--TEE-------------DV--QLRHCLGVFFPVFAYASR--Tn-qECFEEA--FLPTLQT----LANAPASSPLAe 731  human
XP_002286219  763 DTSl-TENhdaeengaevkevGSpvRLQQLLSIFFPTYSMSHL--DandAVMASVgpLLSIINEk---LGGAKSAKALNk 836 
XP_002183659  712 DPNlsTGEmeeeyheeeskeiGSlvRWQQLQSVFFPAYVRRGP--Vy-qEALLNS--ISHILQV----FSSRSQKTTRGk 782 
XP_002504647  712 NVD--ARR-------------RP--RMAQCLAVFFPAIASAPAdrR---ALVAES--SLFALRTsa-------------- 755 
XP_001421348  680 AAD--AQR-------------RP--RLAQCLAVFFPALASGPEdrR---RLLADC--ALPALRAaa-------------- 723 
EFJ32042      696 DED--TKS-------------IP--RLGQCLSVFFHNYASATPehK---RCIAEV--FVPVLRKewpgLTGSACNSHIAa 753 
XP_006828429  716 SEE--TKE-------------LH--RLRQCLSVFFEQYPALSDdhK---RSISEA--FIPTIRAewpgVNGQS-GSPVMv 772 
NP_001348364  724 SEE--TKE-------------LE--RLKQCMSVFFQHYPALSDkhK---SCICNA--FVPVMKAmwpgLYGNAGGSTHVi 781 
NP_198579     742 SEE--SKE-------------QL--RFKQCLSVFFEHYASLSEkhK---GYVSKA--FVPLVRSmwpgIDGNTKSSSYVv 799 
XP_003552880  784 SDV--SEH-------------LH--RLKQCLSVFFELYPCLSAnhK---SCITKS--FIPAMRSmwpgIFGNSSGSTFMv 841 
6IGX_B        732 -------IDITNVAELLV------DLT-----R-PSGLNPQAKTsqd---------------yqAlTVHDNLAMKICNEI 777  human
XP_002286219  837 -------WPITKIVEFICyt---vDLA-----DkKKNAEVETENdependrla--eptevgplsK-SSSDK--------- 889 
XP_002183659  783 ------sLPVVKMIDFVC------ALV-----E---EGVAKADStksateldn--akdeecmalT-SVGLSSAVQIATFL 839 
XP_002504647  756 -----kdKGVAKVASYLA------HLL-----A-CNTQEVEEKEekdgviqtttksvvapavggA-ALVAELAKEALAVT 817 
XP_001421348  724 -----kiKGLSRVAALLV------QLLtasee---------------------------ptaggA-ELALALANESLALS 764 
EFJ32042      754 irk-knaSHLSRFMLELLkqplfsQQNpdesaDf------------------------------A-ILAIDLAREIMRFS 801 
XP_006828429  773 saqrrraTQMSHFMLQMMqaplykFFE-----E-GQENQSNEKDsssptdlkl--dtlglesgeE-GLAIRIGVEVVSYP 843 
NP_001348364  782 skrrklaVQASRFMVQMVqtqlfsTES-----M-----DQASKSsesasglad--asnnfdiseE-GLAIRIALEVASCP 848 
NP_198579     800 snqrkraVQVSRFILQMMqtplykKET-----R-GEPESQVNKSpedsiqh-------plncteE-GLAIRIAIEMLSFK 865 
XP_003552880  842 sqmrkraVQASRFMLQMVqiplyaKEI-----Q-PDCENTNTEHpqvidscv----elpfecgeE-GLALRLAVEVTSFQ 910 
6IGX_B        778 LTSPC--SPE-------IRVYTKA 792  human
XP_002286219  890 -------KEv-------IEASSTL 899 
XP_002183659  840 YASHD----Nlna--agLRALCKY 857 
XP_002504647  818 FRPAPtaaaekqltkayVAALAKL 841 
XP_001421348  765 TKQTPsgaqap-lakayTNAIARV 787 
EFJ32042      802 SRKTLavKAY-------KSALCKV 818 
XP_006828429  844 IKKTAagKSY-------LSALCKA 860 
NP_001348364  849 DKKTAagKAY-------ALALCKV 865 
NP_198579     866 EKKTAheKAY-------VAALCKI 882 
XP_003552880  911 SKKTAseKAY-------VSALCRI 927 
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