Q185A1 15 MVYYIFIVV-LVFFYISqLGSSVS-NDVS---------------KNIP-------NDGNPL---VAPQKVENIEE-YYS- 65 Clostridioides ... 2_pfamImport 1 ISFL-IMIL-VPFIMLGiIYVAGN-FAQQn-------------sDVNKi------GVLADNe-qISQQMSQVKTD-DFE- 55 Q835G8 19 lSFL-IMIL-APFLLVGiVYLAGS-LASGf-------------sGDTTi------GLVSEN-----QALVKELTK-NKTe 70 Enterococcus fa... WP_271867332 19 WSFL-IMVL-APFLAIGlGFLLGK-VSSDn-------------aEDMVk------DVTEIAvvaTSKDLQKQFEN-QTN- 74 Ligilactobacill... WP_015911677 19 WSFV-LMVL-SPFLFLAfSAGIGY-VSGSsa------------eKSNKi------AIILP-----QDNMKAAFKQ-LDH- 70 Streptococcus u... Q03PG8 19 WSFF-FMVI-SPFLMIAlTVGISY-ASADsa------------aSSKQi------AVISDS----ATLRQSYLKQ-HATg 72 Lactobacillus b... WP_015901077 19 RAFIIMTVI-ISLLIIGgANANKI-IDMFn-------------gGPDKi------GIVSEN-----QQVYQMVKSqSAK- 71 Staphylococcus ... Q2FVS4 19 KSFVIFMII-IAALMIGl-SNIDKiINMFd-------------dGPDKi------GVAAPNe-qIYKVFKQQANT-F--- 72 Staphylococcus ... WP_015924688 19 KSFIISTVLiLVIVVAAmVIPAAI-SKSRtggnlnpkeqtqteaSNIKt-----vYFIDKTg--IFEQETNGLQH-QMSg 89 Ruminiclostridi... CDC07628 19 KAFW-ISTI-VIMVLLGvMCAIPRvMSFFdng---------eegTDTKteysgtcYLVDETg--VFEKEIEYLKAaYPG- 84
Q185A1 66 -VHn---QYPYGQKESMKteKVIPNA-TIN--LIREYQKNTYttypt-----------------gvvkyIKLDQ-NKT-- 118 Clostridioides ... 2_pfamImport 56 -FK------AVDSEEKAQ--KELSEE-KID--AYLVVSTENDking-------------------mlysENSLG-QSTq- 102 Q835G8 71 dFS----FKAVSSEKKAQ--EQLKDE-KID--AYLLLDTTDNqisg-------------------qlysERSLG-NATem 121 Enterococcus fa... WP_271867332 75 -VT-----IRYESLDKAK--KALNKD-KIA--GYVSVSLEKGryeary---------------hgkgsiDETSK-AGI-- 125 Ligilactobacill... WP_015911677 71 -VT-----FDYKDVQKAK--KDLKSD-KIL--AYITLSENNQvita-------------------kyfsKEEPS-QSQ-- 117 Streptococcus u... Q03PG8 73 -VN-----RKITQPTQAK--KAMREN-HLA--GYLTLSTTTDrvradyhgnnsl------------------------ss 117 Lactobacillus b... WP_015901077 72 -IEdkgtKFQHVSEKQAI--KDVKNE-KLD--KAYIIKTKGkqvegeivskdsvsdetkqklesiltpiQTQAI-AKS-- 142 Staphylococcus ... Q2FVS4 73 --Hsd-aKFTKVSIEDAE--KEVKKH-KLD--KAYIIKVNQNrtlqgti--------------isekrvSHEDS-QKV-- 127 Staphylococcus ... WP_015924688 90 -FKl--eKVPADKEEGLK--DQIKDKgESY--MIVVSLKDNIpsveyf----------------tkqygSGPNPeMIS-- 144 Ruminiclostridi... CDC07628 85 -MNf--kSIEEDEVKGLE--KAVDES-KSRnvAILSIQEKDAapvlei---------------tvsnflSKVQAdTIA-- 141
Q185A1 119 --KTIEKY-IEeitgksiseinslwktdesikidyskvslerfeE---------Imqrvddilgggsayafdklqrfgvv 186 Clostridioides ... 2_pfamImport 103 --LLIQQQ-LT---------------------------------Glqsm-lrasQlgispee--------------vasl 131 Q835G8 122 liPQMLNQ-LQ---------------------------------Tmana-nrlnLtaeqva-----------------ml 149 Enterococcus fa... WP_271867332 126 --MNVLSR-LQss------------------------------qNivaaqlnddQlhklqvq---------------pnf 157 Ligilactobacill... WP_015911677 118 --KALLTQsLN---------------------------------Glqqt-lnvaKaqisp-------------------q 142 Streptococcus u... Q03PG8 118 giqaqvqnflS---------------------------------Qyqqa-qnyqDakltak-----------------qq 146 Lactobacillus b... WP_015901077 143 --VNLSPKdLQ---------------------------------Alqq-------------------------------- 155 Staphylococcus ... Q2FVS4 128 --QALLTA-IQ---------------------------------TnmvagelniNkedlq------------------kl 153 Staphylococcus ... WP_015924688 145 --KAFKNVyVT---------------------------------Tvlkg-envsEdv----------------------- 165 Ruminiclostridi... CDC07628 142 --DACNKI-WQ---------------------------------ShlltengleK------------------------- 160
Q185A1 187 pvtYDEAMKNYNYTIq------kDKVS--NGYARIFCD----YIGIVLSIFPVFVAVFMSLKDKRSrMREIIYSKqVSSC 254 Clostridioides ... 2_pfamImport 132 sqqASLTRQKVNFDSkgkmtvgeDNSTv-QYVVSYVAT----IVLFIIILTYAQIIAQEIASEKGTrIMEVILSS-TTAQ 205 Q835G8 150 nqqATFKKAKISFDEngk--iktGEDN--TGIQMALAMgi-tILLFVFISSYSSIIAQEIASEKGTrIMEVILSS-TKAQ 223 Enterococcus fa... WP_271867332 158 veiKNSASKQNQIDKkq-----qEKFA--NKTAYMILL----FVMYFILITYSTTTAQEIGSEKGTkIMEVLFSS-MPAK 225 Ligilactobacill... WP_015911677 143 qleTLSTQAKLDVQTtn-----hTNYDkiSKYISFYGVt---FIMYMILIIYTSQTAQEIASEKGTkIMEVIFSS-VPAN 213 Streptococcus u... Q03PG8 147 rllARTPVFKQHIATkag---ttNLTR--TISFWILIT----MIYIILITYSSI-TAQEIASEKGTkIMEIIFSS-TTAT 215 Lactobacillus b... WP_015901077 156 --qskVTAKVVGKDAkql---seQDKV--ANIIILYAGi---MLMFFIILNYANQVAMEVATEKISrVIEMVITS-ISPV 224 Staphylococcus ... Q2FVS4 154 qaqSKVDNKVISNDEvd----kvSEGQ--KIFNYALAYgi-iFLMFFIVLNYASQIAMEIASEKTSrVIEMIITS-ISPI 225 Staphylococcus ... WP_015924688 166 -itKTLADLNINVNElg-----nSKVG--GFVSSIFIV----IILFFAIYFYGYGVSMSVASEKTSrVMELLITS-VKPS 232 Ruminiclostridi... CDC07628 161 ---GEVDAIQTPLIYtq-----rFIGN--MNLTEYVVGllltFVMFFAVYYYGYGVAMSISSEKTSrVMETLIIS-AKPS 229
Q185A1 255 KIVLSRYFALVFMMILPVLILGmkdllpL---I----FFAkd-----------------------kgISID--NL----- 297 Clostridioides ... 2_pfamImport 206 KHFYGKLTGVLLVALTQMALYG------I---I-----FGigysqfkdm---------emvknildgISLD--NLigpfl 260 Q835G8 224 THFYGKLTGVILVALTQIFIYG------Va--F----VLGysqlknldfmk------sllsgispqsIFSS--TF----- 278 Enterococcus fa... WP_271867332 226 NYFYGKMLGLTMVIVLHISIYA------IgggV----IYAlaprlwgde---------alfrtayemINIIfkHL----- 281 Ligilactobacill... WP_015911677 214 HYFYGRILGIFAVILTHMTIYV------AggyL----CFKlanklemtke-------wiqnmkplldSLIK--HLd---- 270 Streptococcus u... Q03PG8 216 SYFVGKIAGIMLVILTQIGIYL------LggwA------GysiavnnaalkplladnqalingvihnLFNI--NL----- 276 Lactobacillus b... WP_015901077 225 KHLLAKILAIILVAFTQVLIFV------V---Vg---AISiylsdlrdiv--------kkfnvkftdVTMH--LL----- 277 Staphylococcus ... Q2FVS4 226 QHIFAKILGVIAVAVTQIILIV------L---MavicIFAfdlkdl----------------lqgfnVEMN--QLswqii 278 Staphylococcus ... WP_015924688 233 RIIIGKTAGMGVLGLIQLALII------G---Vga-vTYKavfptdftidg------mkldlsgftpFTFSm-VI----- 290 Ruminiclostridi... CDC07628 230 KILIGKCLAMGVLGLLQLVGLM------A---Faa-fCYKfilpegfqi---------agvdlavsgFTPK--TL----- 283
Q185A1 298 AFikyTL-WWILPTLMIVTAVGMSITILT-DTP-VAI-I--VQLIWWlys-inSTGL-K-----GDYS-----TMGLMIR 359 Clostridioides ... 2_pfamImport 261 WY---SL-LFMIFGILIFSVLAALCGSLVnKAE-DTA-KaiLPVTYLslg-gyMLGL-Ilg-asDPNNiviriTSYIPFL 331 Q835G8 279 IF---TL-GFFIIGILVFAVLAALCGSLV-SKPeDTA-KavQPIMYIgli-gyMIGI-Tfg-tnDPQNivvkvTSFIPLI 349 Enterococcus fa... WP_271867332 282 IS---INlVYVLLMIILCTVLAALCGALV-VRI-EDS-NkaVQPVMYlii-agFIASmAfq--gKPESvivvaLSYIPGV 352 Ligilactobacill... WP_015911677 271 WS---IL-FFAIFGILLYVVLAALCGSLV-VRP-EQA-NqaAQLPIFlvi-aaFMGA-FvlgqgNSDPlllkiGSYLPFF 341 Streptococcus u... Q03PG8 277 LF---LF-LGVVIYTILAAYSGALVAKAE-DAS-KAA-QpvVMLSMLa-----FFAA-Fpf-qnNLDAlavkiLSYIPFF 342 Lactobacillus b... WP_015901077 278 IV---GV-ICFIIGIISYTILGTILGSLA-TRI-EDMnQalMPMTAVsfi-afYIAL-Lnl--nTPETmltkiASFIPLL 347 Staphylococcus ... Q2FVS4 279 IV---GI-ISSIVGITAYVLLAAILGSLT-SRI-EDL-NqsLMPLTLlgmiafYIAI-Fti--nNPDGqlaliTSYIPFL 348 Staphylococcus ... WP_015924688 291 IY---FI-LGYTLYALMYAVVGATVSKAE-DVN-SAM-Mp-MSFIAIiaf-yfSYGT-Fav----pDStaakiASIIPFT 356 Ruminiclostridi... CDC07628 284 VF---LI-IYFILGYALYAVMNSVCGAAV-SKM-EDL-NsaMMPVSIlviigfYLGY-FtsvmgGGSGmlsklAVYLPIS 355
Q185A1 360 HNSVLNGDIIIqn--fnQIMINRIVISLGALVLVL-LAIF 396 Clostridioides difficile 630 2_pfamImport 332 SSYIMPVRLANetvgmgGALISLLVLVAVTFLLMI-LSAN 370 Q835G8 350 SSYIMPVRLATetastmEAIVSLVILAVFGIILTI-FSAr 388 Enterococcus faecalis WP_271867332 353 SAFFMPLRIINgtvgtiGIGVSLTLFLATVILA---Ivwc 389 Ligilactobacillus ruminis WP_015911677 342 STFFMPIRLINgf---aHLNQSLISLLILALTTLF-ITMY 377 Streptococcus uberis Q03PG8 343 SSYFMPMRIINnt---aNCGEQLISLTILLATIGL-FALY 378 Lactobacillus brevis ATCC 367 WP_015901077 348 SPFVLFLRASTpe---lQLWEIIVSVLLSLIVMILlLWIA 384 Staphylococcus carnosus Q2FVS4 349 APFQLVVRAQTsglqiyEVILSSLISIVMVAVLIW-IAIk 387 Staphylococcus aureus subsp. aureus NCTC 8325 WP_015924688 357 SPFSVPSRLVStsiplwEIGVSLGVLLIAITFVGM-ISVK 395 Ruminiclostridium cellulolyticum CDC07628 356 SPFAVPFKLITgeitmkELGISVFLLVLAIVIVTM-FStr 394
Jiyao W et al.(2023). "The conserved domain database in 2023.",