3KF8,3KF6


Conserved Protein Domain Family
Ten1

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pfam12658: Ten1 
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Telomere capping, CST complex subunit
Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast, and a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. S.pombe has Stn1- and Ten1-like proteins that are essential for chromosome end protection. Stn1 orthologues exist in all species that have Pot1, whereas Ten1-like proteins can be found in all fungi. Fission yeast Stn1 and Ten1 localize at telomeres in a manner that correlates with the length of the ssDNA overhang, suggesting that they specifically associate with the telomeric ssDNA. Two separate protein complexes are required for chromosome end protection in fission yeast. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution. Ten1 is one of the three components of the CST complex, which, in conjunction with the Shelterin complex helps protect telomeres from attack by DNA-repair mechanisms.
Statistics
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PSSM-Id: 403757
View PSSM: pfam12658
Aligned: 22 rows
Threshold Bit Score: 59.6816
Threshold Setting Gi: 156844867
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3KF8_D         2 SkiilIPSNIPQE-------FPE--ASISNPERLRILA-----------------QVKDFIPHESTIVIDKvpTITSeqs 55  Candida tropica...
EDU44870       2 Ss---TPVASNLV-------LLRdlPTCPHGTKVRFLGwyiastpwrlrftdqkaSVDEYIVETATLRLKH--DYPVssp 69  Pyrenophora tri...
CAP72813       2 Sf---GPLPSQLC-------LLSslSQKDIGDKVRFLG-----------------CVTSYSTESGVLTLQYrgsed---- 50  Podospora anser...
EDN94733       3 SmmtlVP------------------------------------------------SVTNYDRTSAVLTLEH--NFPVdng 32  Sclerotinia scl...
XP_001645494   2 SkillNVSDLTDLinninqsDNNssNNEDESMRIRMFVqlvd----------iryCEPDRKGRRSQLVVQDltDYRKrds 71  Vanderwaltozyma...
EDK38920       2 TnlvlDASCLSVL-------FPK--ASEENLVKVRIFG-----------------QIVDYDGQHGVVTIRKvpGMPSphv 55  Meyerozyma guil...
Q6BH72         2 TklilDPLSLSLE-------FPK--ASESRLHRVRILC-----------------QVIEYDDLTATLKVRKvpNIHKfht 55  Debaryomyces ha...
Q5A873         2 TklilNPGDLSSI-------FPD--ISISNPQRIRILC-----------------QVIKYIPNESCLIIDKipTVAEsst 55  Candida albicans
3KF6_B         5 D-------SAKLI-------FINqiNDCKDGQKLRFLG-----------------CVQSYK--NGILRLID--GSSS--- 46  fission yeast
XP_002175364   2 D-------SAKLI-------FAEqlAGCSTGDKVRFLA-----------------CVEEYK--DGIVVVRD--GGHR--- 43  Schizosaccharom...
3KF8_D        56 ------------tyINICIFNLLEA-CSSR-----------------VLVPGTLVNIDAFYDGES------------INP 93  Candida tropica...
EDU44870      70 -----------plvANLNIEHVLDR-VKRH-----------------EVDVGTWLNVIGYVQRRItdke-----gvfVQA 115 Pyrenophora tri...
CAP72813      51 ---------rqltfASVDVNLVLQS-LKAE-----------------QTRVGEWVNVIGYVTSTDskklgdtnpvveVQA 103 Podospora anser...
EDN94733      33 ------------fkALVNIQLLLNS-VKSH-----------------ETRIGEWVNVVGYV----------------VDI 66  Sclerotinia scl...
XP_001645494  72 tdg-----cdelktVSLMIDDSLFQeVFGDgfknsdmgmapqlgdpiDIRIGLWNNGVc-----------------cTEV 129 Vanderwaltozyma...
EDK38920      56 vslededsapneecTSIDIKSVVDT-LKSG-----------------DLDPGCLVTIIGFYNGED------------INV 105 Meyerozyma guil...
Q6BH72        56 einlidepvaeaytLNVNLFGVLNK-MNAE-----------------SISVGTIVNIVGYFNGEK------------VNV 105 Debaryomyces ha...
Q5A873        56 n---------keslVKIDVFDILEDiLSIE-----------------IINKGTIINIDGYYDGEK------------IQP 97  Candida albicans
3KF6_B        47 --------------VTCDVTVVLPD-V--------------------SIQKHEWLNIVGRKRQDGi-----------VDV 80  fission yeast
XP_002175364  44 --------------IKCDVSAVLPQ-I--------------------RVYRHEWVHCVGRKRADDs-----------VDV 77  Schizosaccharom...
3KF8_D        94 VDIYEVNGANFTMEn-IQLID 113 Candida tropicalis MYA-3404
EDU44870     116 LCIWDAGNLDLAAY--SKAVE 134 Pyrenophora tritici-repentis Pt-1C-BFP
CAP72813     104 TLLWSAGPLNLEKY--EASVQ 122 Podospora anserina S mat+
EDN94733      67 GEHQDTKRTDLNTR--GRVSR 85  Sclerotinia sclerotiorum 1980 UF-70
XP_001645494 130 LDIKRISLQELTIL--KEFLS 148 Vanderwaltozyma polyspora DSM 70294
EDK38920     106 VECCSVNGTYISPR----VMD 122 Meyerozyma guilliermondii ATCC 6260
Q6BH72       106 IECYSVNGSSMIPEnnIKVLA 126 Debaryomyces hansenii
Q5A873        98 IDIYEINGINFTIEn-IEILN 117 Candida albicans
3KF6_B        81 LLIRSAVGINLPRY--RQMVS 99  fission yeast
XP_002175364  78 LLFQSAVGMDLARY--REMVV 96  Schizosaccharomyces japonicus yFS275
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