Conserved Protein Domain Family
Vezatin

?
pfam12632: Vezatin (This model is not part of the current CDD release)
Mysoin-binding motif of peroxisomes
Vezatin is a peroxisome transmembrane receptor that is involved in membrane-membrane and cell-cell adhesions. In the movement of peroxisomes it binds to class V and class VIIa myosins to guide the organelle through the microtubules and allow pathogens to internalise themselves into host cells. Vezatin is crucial for spermatozoan production. In mouse cells it interacts with the cadherin-catenin complex bridging it to the C-terminal FERM domain of myosin VIIA.
Statistics
?
PSSM-Id: 520373
Aligned: 28 rows
Threshold Bit Score: 130.938
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_001641926  158 LFAMFVALAALAFnp-----itYShFTKPLVYTLTILAVTlvvLVVSffTVTYLKFRISKQYWRYIGILREYCSNIRSLL 232 
1_pfamImport    1 --FALAWLTHWTR----------ShGSPSARRGRMAILLFviiLVVAvsYAHMRRQWLQYLRQQSLAEISGFAAKAQRLD 68  
5_pfamImport    1 -AFSLAWLIHWAR----------TsARSAAGRGRLAVMLTvlgIAGMisYAYFRRQWLQNLRQETVTELSNLIVSAYELD 69  
XP_011275534  231 ILGVLSHLQKHKG--------------NYQNSQIRLVIIIsliILNA--HTISHTQSLDLIQHKTLNQLKRFIKIQQKFD 294 
XP_002617729  183 TVLLIVYLLKQRLlp------rQTlDSSQHYQLFKLLLIMatkIVKF------QRAAILIYSSKTLRSLDDFMLSNCQIN 250 
Q59N02        327 VILMIIYLLKQQQlmsyqhhhnYGlSIKIQFKLFKIIIYIsmkLIKV------KKFKLIIESNQILLNLQKFLILNYKIN 400  Candida albicans
XP_001382466  296 IINLIIFLMKQEQrrhl--nysATmSYSNRMKMFKILLIIstkLIKF------NRFKLLVMSQSNLSYLNSFLLSNYSIN 367 
XP_007373754  183 IINLIIYLLKQRKt-------nEHtNQSNQLKFFKIILIIstkLIKV------KKFRTLVQTSQILNLLNEFLMSNYIVN 249 
KAJ9113383    164 VIHLIIFLIKQSLke------dSHlLSHSKHKLFRILLVVstrMIQF------KRIGLRIKANKILNYTEEFLKLNYKIN 231 
Q6BGY9        189 TIYMIIFLLKQSLkg-----vkSKmSTQNKFKMFKILLIIsvkLIQF------KRINLKIQSTKVLNMLNDFLVNNYKVN 257  Debaryomyces ...
XP_001641926  233 LLVRKSINMIQE--VELICRGQML----VGSGMPKGMLstslNDNFENVIYPKLRQCMFDKLSNIHEQTSKAAKNLNEnL 306 
1_pfamImport   69 SAIGAALTLVQE--VELVSRGYRL----STPLPPVSRI----EERCQTRRCARLRKQLLRCFSAVIPRYNQACVALKL-L 137 
5_pfamImport   70 RAAANAISLVQE--VELVSRGYRI----SSPLPPISRI----EDRSQSRRCIRLRKQIRKSFVDVTTKYVEAVSQLQP-L 138 
XP_011275534  295 LQEQKLITKYKE--LKLYNNILPI------------------QQQHSSEDPSQLFDLVSSTIIVASTSVINSIHKILP-Y 353 
XP_002617729  251 KDIITSIITLKE--FQMFSFLDRP------------K-----QEQISSGYPKDLAKHLNTTLRLLSLNMKHSISALLP-F 310 
Q59N02        401 KKLIIQLINLKGdqLNLISNS---------------------SGGGGDGFEQQLKQYLFNILSLLNLNLQNSIIKLLP-F 458  Candida albicans
XP_001382466  368 KKLIQKLIILKE--LDVYYYVNRNkdeaNH------------DSKSREVYKSSLREHLANTLHFLNLNLRTSIARLLP-N 432 
XP_007373754  250 KKIILQMIRLKE--LHTYNFLP--------------------GQGDNVSYKSHLHSHLLSSLSFLNLNLKSSIMDLLP-V 306 
KAJ9113383    232 KKLISHMIRAKE--MAIFTGTS--------------------LSSSGSNDPTSLMKTLDETLSFLIFNLKSSIVRLLP-F 288 
Q6BGY9        258 KKLIMNLINLKE--MEIFGFMK--------------------NSAISKNKVHDLKENLDNTLNFLNFNLKSSIIKLLP-F 314  Debaryomyces ...
XP_001641926  307 AQFPELDSMFTSMSVAPMesLFVQE--------------------ASLSTHHLKNLLAIAASQQSEFLSRYLLLLSDQAY 366 
1_pfamImport  138 AEELDLEKYFDIYDINDS--DFSDAmagfs----------ekefeDAESVRVLKILAARFCTSRTIFLCCLMALDADGAK 205 
5_pfamImport  139 AEELDLEKYYDIYDITEN--DLTEAslgys----------eieaeDQESVRTLKLLAARYNTLRRIFLCSLMALNADGNK 206 
XP_011275534  354 VNGYELENYCELYNIELTqlGFETEnlkpf-----------niseSESSIDQLVNKFRRFQYLRRFLIVLFLAMNHQFST 422 
XP_002617729  311 SNGEILEKYCQINNVQMS--WIFEEhde--------------sieEVSSLEILTSKLGHFNNLRRFFICQLLTIHDPPSH 374 
Q59N02        459 MNGELLEQYCLMNNIKID--ILNQDneiistvgrg-ytlgsnsnsNSSCLDNVKFHFKKFDNLRKLFICQLLIINQ-PSK 534  Candida albicans
XP_001382466  433 LNGDLFEQYCNLNNIDIL--LLQEDyrdgdeeelngmdspvssskEKNSLDEIVFNMNKFNQLRKLFICQLLTINESSVK 510 
XP_007373754  307 LNGDLLQQYCNINSIDLE--ILTQEytp--------------ddnQDEYINEIIFNITKFNQLRRLFICQLLAINQTPVR 370 
KAJ9113383    289 LNGPTFEQYCHINNINID--ILGKSld-----------------eTELTIDTLRSKLDKFHKLRKMFLCQLLTISERQSY 349 
Q6BGY9        315 LNGPMFEKYCNINNINVC--TLNSKydadgti-------einrssEKITIDELTFKLNKFNQLRKFLVCQLLTVNESPIR 385  Debaryomyces ...
XP_001641926  367 GDMEERSVQ--------------------IELMSKMNTVFIEPACTIaqalaslqrsyhaHKVAMNFSGE---------G 417 
1_pfamImport  206 PDFDRWSTA--------------------VEQIQGVALVTGDAEDRL-------------RRILSEEENFsisptpqvpT 252 
5_pfamImport  207 NDFHVWKIA--------------------LERIRDTRVATASAGARL-------------ATLLNTEESFpvpptpklpL 253 
XP_011275534  423 HSPFLMKVFgifqiksrltcsilkssvlvSQ------------------------------------------------- 453 
XP_002617729  375 -NFFISKIRdy-------------------------------------------------------------------lP 386 
Q59N02        535 PNFFLFKLMdqfnid---------dsnssSSFSENFFNNSVPIFDSL--------------------------------- 572  Candida albicans
XP_001382466  511 KNFFIYKLMdqfpp------------------------------------------------------------iktedW 530 
XP_007373754  371 YNFFIYKLMdq--------------------------------------------------------------------f 382 
KAJ9113383    350 -NFFLSKAWdlfnlp---------qaetrELCSTPISVLE---------------------------------------- 379 
Q6BGY9        386 -SFFLFQVWdqfnit---------eyevdEVLQNDFLFFE---------------------------------------- 415  Debaryomyces ...
XP_001641926  418 DPSPKQQHLAPQSNWILFSTAIHSLELHLK 447 
1_pfamImport  253 TP-GRERCRAQLRKLNSLSTGIRGLQAKL- 280 
5_pfamImport  254 TP-GRERWRAQSRQLNSLSTGIRGLQAKLQ 282 
XP_011275534  454 -------------SLESLQELISGLVESLS 470 
XP_002617729  387 TPIKTSTYTSTIDKLKSLQLVFQEHTAALE 416 
Q59N02        573 -------------RLKIIHDLLIDHNLTLS 589  Candida albicans
XP_001382466  531 ERDDDITAFNNIAKLGFIRQVLHDHNKITN 560 
XP_007373754  383 NLDSREVQISDYNRLNLIKRVMTNHNQTSS 412 
KAJ9113383    380 -------------KFIILEDIFHEHNQTVS 396 
Q6BGY9        416 -------------KLLVVEELFEEHTNIVK 432  Debaryomyces hansenii
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap