Conserved Protein Domain Family
TFCD_C

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pfam12612: TFCD_C (This model is not part of the current CDD release)
Tubulin folding cofactor D C terminal
This domain family is found in eukaryotes, and is typically between 182 and 199 amino acids in length. The family is found in association with pfam02985. There is a single completely conserved residue R that may be functionally important. Tubulin folding cofactor D does not co-polymerise with microtubules either in vivo or in vitro, but instead modulates microtubule dynamics by sequestering beta-tubulin from GTP-bound alphabeta-heterodimers in microtubules.
Statistics
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PSSM-Id: 520360
Aligned: 94 rows
Threshold Bit Score: 73.7975
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009012143  915 LKIFQSFVQQSCEKIDRTRSLAGNLFYKLLYHIPAv---------------------PQIPEMDRL-KDVF---KYKeks 969 
XP_003291594 1085 TEFISKLIQLSGEKLDKIRDVVCKIIHQILWMEPTi--------------------kTIIPHREEL-LKIFvkvPDDhfn 1143
XP_002675465  876 TSLMCSLLKQAVEKIDRVRDNACRSIVRILANEHS----------------------KNIPLREEIsQIIH---SSDdgs 930 
XP_001582319  804 KELVIDVLKLCLDKITGIREYAVKILLKIAYYTEDlpnresvlrllksqnkanvpdaDKLPLLEDV-LKIL---NKDqta 879 
Q10197        821 WCCISYIIRQTFDKIDSLRGLAYQALEQIRVH-------------------------YLIRRCEAL-TNII---N-Rir- 869  Schizosacchar...
XP_003837159  927 HKIYANVLRLSLEKLDKMRVTAAHV----LQHGPQ----------------------STSNANTKL--------PTDdv- 971 
ELR04417      892 GSLYSRTLRLSAEKLDKVRGEAQTALAILIQDSIQh---------------------SAFTSANHVsRTYF---RHLldl 947 
XP_007807717  951 RQLFPCILRLAAEKLDRVRPEAQAVVALMMKERYAh---------------------PSWYRKCNK-KKAD---NKSasd 1005
XP_003714367 1032 LTLFPKILRLSAEKLDKVRAEAQTALALALNQDWAlklr--------------rstySSRPYHSFL-LSL----PTTtse 1092
XP_009650360  947 SKLYLNVLRLAAEKLDRVRTEAQAVLSLTLTPSYAvwf-----------------nkLTFSSRTYL-LALL---Tly--- 1002
XP_009012143  970 m----inwsSPKQ---TFPL-FAQL--LSS-----------RH---YSYHVTLGFVV-SVGGLTESLVKCSAENLIKQLK 1024
XP_003291594 1144 -------wfRTEE---SLPL-ICLI--LQF-----------DI---YLYPLLFGLFS-SLGGNSKYLIDDSINSINNYFN 1195
XP_002675465  931 l----vdwsSAEK---SFPI-FVKL--LPL-----------EI---YRYSLLSGLVV-SMGGMSSHVFKHSTTALIDYLk 985 
XP_001582319  880 pkw-levmrLAEVqniSIEH-FNQL--IVV-----------PD---YAETVVEGLIS-CSGAFAPDLSKRSRNSLLSFMr 940 
Q10197        870 --------nNPNMdgeVLNElNISL--LEI-----------PN---LRLQAFYGITVfTADGFGSDLAVKCFEFYLSYVY 925  Schizosacchar...
XP_003837159  972 --------sSPAY---FLAA-LQSL---KR-----------ARnarIREAISTGYVN-SAGMGSESVVQHARIALLDFID 1024
ELR04417      948 ------qlpSSAS---WLSNtHLHL--H-------------QR---WTDHLFDGYVS-AADSGAEGLIRASRAALNDFCf 999 
XP_007807717 1006 sesfrsltfSSRA---YFET-LLKL--ILSdslspalepseADrsgWMAELMSGLVT-SADAGNDDLVIASRAALTDFCe 1078
XP_003714367 1093 -------rlHPSVs--ATPV-LRDA---DA-----------SR---WMEELMTGYVT-SADAGHEDLVIASRGALAAYCa 1144
XP_009650360 1003 --------aQDEY---IHPL-IMELarADP-----------GA---WMAELLAGYVT-SADTGNEDLVIAARAALTEYCs 1055
XP_009012143 1025 LMPV-----DDLK-----SFCDVFIRLF----EDHHKSDRVIVPIFKTIDKLITSDCFANLDECCknEF--MMQLVKLTI 1088
XP_003291594 1196 NYKNee-keNKII-----KFLQTVLEIS------QNVPERMVQPTFKSITNLLLTHHFDFIITTKdkSI--LERILFICY 1261
XP_002675465  986 t------sdDMSE-----KILTVMLEIG----VQYALDDRVIVPLLKSYALLIGHGVFERFQPPQ---YdyTEKLIVATT 1047
XP_001582319  941 kk-----gtDNAK-----LVSSIIIQLY----TKQWGIVNFQNSLFAFLPLLLGSGVLSGENLAD---F--ADKFLSVTE 1001
Q10197        926 QLEDsfkksNSRYgk--rDLLQLYIDIL----SSEDEIARFYFPIMKSFTSLLAYGCFTDFQNVK---G--MSKAIFIVQ 994  Schizosacchar...
XP_003837159 1025 TLPTsstgnTSTSnfsllDFASCLTSLL----KSNLDNDRVLLPLLEVLAFLFDMQVLERLQDTSsfS---FRTLLSLTQ 1097
ELR04417     1000 a------apANRE-----LVCNTLVGSVk--rLHDAGDERVLLPMMSVVAFLFDAGILEGGHKG-------LRGLFLATQ 1059
XP_007807717 1079 t------sqRHVD-----MVCNALALNL----RAHYADDRIAVPTLEIIAFLFRVGIFHCSRGVD------FRTLCLYTQ 1137
XP_003714367 1145 r------sqDDLD-----RACGALARNLarlsRQQPQPDRVVVPTLNVAAFLFHVGVFSRCSVVD------YKALCLAVQ 1207
XP_009650360 1056 m------apANRD-----DVCTALVRNL----SSRQGQDRVLVPTLEIVAFLYRAGLFAGCRGVD------PKRLCLLVQ 1114
XP_009012143 1089 SEITK-CKDVKK 1099
XP_003291594 1262 ERIKAsHDDIYL 1273
XP_002675465 1048 KEIVGtCKNVQK 1059
XP_001582319 1002 QKYFN-KKTPQK 1012
Q10197        995 RRALT-CKSPGG 1005 Schizosaccharomyces pombe 972h-
XP_003837159 1098 KSHFK-SSNMQK 1108
ELR04417     1060 RAHFK-SGNVRK 1070
XP_007807717 1138 KAGYK-TGNVRK 1148
XP_003714367 1208 RCGYK-TGNVRK 1218
XP_009650360 1115 KAGYK-TGSIRK 1125
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