Conserved Protein Domain Family
TFCD_C

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pfam12612: TFCD_C 
Tubulin folding cofactor D C terminal
This domain family is found in eukaryotes, and is typically between 182 and 199 amino acids in length. The family is found in association with pfam02985. There is a single completely conserved residue R that may be functionally important. Tubulin folding cofactor D does not co-polymerize with microtubules either in vivo or in vitro, but instead modulates microtubule dynamics by sequestering beta-tubulin from GTP-bound alphabeta-heterodimers in microtubules.
Statistics
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PSSM-Id: 403718
View PSSM: pfam12612
Aligned: 105 rows
Threshold Bit Score: 68.7933
Threshold Setting Gi: 552841700
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002897115 1015 LFGSLAKQLAEKLDNMRMTAGSILFRLLHSTNP----RiDGIPDRFQL-EKFFPSS--LVVNWS----MARDTFPL-VVK 1082 Phytophthora ...
GAD97086      956 FVGCLCRLSAEKLDKVRLQAWLSLQKFWKSA--------KDFPPLERE-YEHF--------SLV----SSPSYFRQ-LLE 1013 Byssochlamys ...
EAW13059      949 IIGCLCRLATEKLDKVRLQAWICLQDFWESA--------EDFPPLQNK-YDHFSHV------------SSTEYFTQ-LLH 1006 Aspergillus c...
XP_002381117  951 IVGCLCRLAAEKLDKVRLQAWICLQGFWKST--------DDFPPLQRQ-YEHFSHV------------SLPDYFLQ-LFE 1008 Aspergillus f...
XP_002144816  954 FIGCLCRLAAEKLDKVRFQAWTCLQQYWKHA--------SHLPPMERQ-FEHFSQV------------SSFNYFHQ-LLQ 1011 Talaromyces m...
EED23257      954 FIGCLCRLAAEKLDKVRFQAWVCLQQYWGDA--------THLPAMERK-FEHFSQV------------SSFNYFHQ-LLK 1011 Talaromyces s...
XP_003837159  929 IYANVLRLSLEKLDKMRVTAAHV----LQHGPQ------STSNANTKL-----PTD-----DVS----SPAYFLAA-LQS 983  Leptosphaeria...
XP_012739890  894 LYSRTLRLSAEKLDKVRGEAQTALAILIQDSIQ----H-SAFTSANHVsRTYFRHL--LDLQLP----SSASWLSNtHLH 962  Pseudogymnoas...
XP_007807717  953 LFPCILRLAAEKLDRVRPEAQAVVALMMKERYA----H-PSWYRKCNK-KKADNKSasDSESFRsltfSSRAYFET-LLK 1025 Metarhizium a...
XP_009650360  949 LYLNVLRLAAEKLDRVRTEAQAVLSLTLTPSYAvwfnK-LTFSSRTYL-LALLT-------LYA----QDEYIHPL-IME 1014 Verticillium ...
XP_002897115 1083 M--LDI-----------PE---LTEEVAAGLVVSVGGLTESVVKASEGALFEWVRAHSQ-TKKFGLLT-----RFSFFLV 1140 Phytophthora ...
GAD97086     1014 L--LNV-----------DW---LRFPLIQGLITSASAGTENLIRSSRSALIEYINDQDK-ERRDGVVA-----QLIRESQ 1071 Byssochlamys ...
EAW13059     1007 L--QAI-----------DW---LRLPLYQGLATSAVAGAEGLVRSSRLALVRSISNYSE-EQQQSKAI-----AILSDLG 1064 Aspergillus c...
XP_002381117 1009 L--QAI-----------DW---LRLPLFQGIATSAVAGAEGLVRSSRLALVQRINKYEA-EQRQDIVT-----SIIKDLM 1066 Aspergillus f...
XP_002144816 1012 L--LQI-----------DT---LRRPLVQGLITSASAGTEGLIQSSRFALIDFIESQPSdEKKYEWAN-----KLIEDII 1070 Talaromyces m...
EED23257     1012 L--LQV-----------EN---LRRPLVQGLITSASAGTEGLIQSSRFALIDFIENQPNrEKKYEWVN-----KLIENLV 1070 Talaromyces s...
XP_003837159  984 L---KR-----------ARnarIREAISTGYVNSAGMGSESVVQHARIALLDFIDTLPTsSTGNTSTSnfsllDFASCLT 1049 Leptosphaeria...
XP_012739890  963 L--H-------------QR---WTDHLFDGYVSAADSGAEGLIRASRAALNDFC------FAAPANRE-----LVCNTLV 1013 Pseudogymnoas...
XP_007807717 1026 L--ILSdslspalepseADrsgWMAELMSGLVTSADAGNDDLVIASRAALTDFC------ETSQRHVD-----MVCNALA 1092 Metarhizium a...
XP_009650360 1015 LarADP-----------GA---WMAELLAGYVTSADTGNEDLVIAARAALTEYCs------MAPANRD-----DVCTALV 1069 Verticillium ...
XP_002897115 1141 TLL--TRHHQDDRVTIPLMKTMALLLESNLLRFLLEKRqveddsevttaDFGERLYSALRDEIQKCTAVPK 1209 Phytophthora infestans...
GAD97086     1072 LVL--ESNLEDDRYAIPAMDMLSFLLDSCVTTVSTGSE-----------PIFRKVFFIVQKAHFKSSNMAR 1129 Byssochlamys spectabil...
EAW13059     1065 AIL--SDNLHDDRYAIPVMEFAAFFLDGYVTSSLDVSEt----------G-LRRLFTLVQKAHFKSPNMAR 1122 Aspergillus clavatus N...
XP_002381117 1067 VAL--SDNLQDDRYAIPVLEFLAFLLDSYVSSIPQPSEs----------S-YRKLFILVQKAHFKSSNIAR 1124 Aspergillus flavus NRR...
XP_002144816 1071 SIL--ETNLVDDRYAVPALEISAFLVDMYISEAAVQANk---------aC-LKKLFLLTQKAHFKSSNIPR 1129 Talaromyces marneffei ...
EED23257     1071 SIL--ETNLVDDRYTIPALEVSAFFLDTYISEPLVQANk---------pC-LKKLFLLTQKAHFKSSNIPR 1129 Talaromyces stipitatus...
XP_003837159 1050 SLL--KSNLDNDRVLLPLLEVLAFLFDMQVLERLQDTSs---------fS-FRTLLSLTQKSHFKSSNMQK 1108 Leptosphaeria maculans...
XP_012739890 1014 GSVkrLHDAGDERVLLPMMSVVAFLFDAGILEGGHKG--------------LRGLFLATQRAHFKSGNVRK 1070 Pseudogymnoascus destr...
XP_007807717 1093 LNL--RAHYADDRIAVPTLEIIAFLFRVGIFHCSRGVD-------------FRTLCLYTQKAGYKTGNVRK 1148 Metarhizium acridum CQ...
XP_009650360 1070 RNL--SSRQGQDRVLVPTLEIVAFLYRAGLFAGCRGVD-------------PKRLCLLVQKAGYKTGSIRK 1125 Verticillium dahliae V...
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