Conserved Protein Domain Family
CK1gamma_C
?
pfam12605: CK1gamma_C (This model is not part of the current CDD release)
Casein kinase 1 gamma C terminal
This domain family is found in eukaryotes, and is typically between 54 and 99 amino acids in length. The family is found in association with pfam00069. CK1gamma is a membrane-bound member of the CK1 family. Gain-of-function and loss-of-function experiments show that CK1gamma is both necessary and sufficient to transduce LRP6 signalling in vertebrates and Drosophila cells.
Links
?
Statistics
?
PSSM-Id: 520356
Aligned: 12 rows
Threshold Bit Score: 71.8149
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
EFN77420     263 KPMSTPVGSLQTGQEIVVSP-NRDRH-PAAYKeyddfeedvvlmmdevrfelqgqydvagggvgggGGKGVGATWPDT-- 338
7_pfamImport   1 KTMSTPVGSLQTGHEIVVSPgNRDRH-AAIKG----------------------------------GGVKGLSAWPDA-- 43 
EDS32121     298 SAKSTPVGSLQTGHEVVVSP-NRERH-TPVNKdgdffsyydeeld--------davtleimaqqqtNSKGGVAAWPDV-- 365
EFX89320     312 KTMSTPVGSVSTNQEVIISP-NRERH-PATNRvr------------------------------rvKASAASAGTSGG-- 357
EEC11649     334 KQMSTPVGSLQTGQEVIVSP-NRERH-ITTNArs-------------------------------nPQKNAWLDQGGGnp 380
6_pfamImport   1 RPIPTPVGPLPVHVESGPSV-TREVH-PHRDR------------------------------------------------ 30 
XP_007244372 328 RQIPTPVGSVPVD--SGASAiTRDTH-TNRDRpsqhqpl--------------------rnqtassEHRGAWDVQPHR-- 382
XP_029702483 333 RQIPTPVGSVHID--SGASAvTRETH-PHRDRpsqhppi--------------------rnqtavsDRRGAWEVQPTR-- 387 torafugu
XP_029684726 331 KSLPTPIGPIPSD--TPLQPsSRDKA-QQQTKnq-------------------------------sPEPKGSESQPTP-- 374 torafugu
XP_029684725 332 KSLPTPIGPIPSD--TPLQPssRDKA-QQQTKnq-------------------------------sPEPKGSESQPTP-- 375 torafugu
XP_005171263 335 KPLPTPIGPMPSD--TPLQPsNRDKAqPQTKNq--------------------------------sPEPKGSESQPTP-- 378 zebrafish
XP_005993849 332 KPLPTPVGPVHND--TSVPP-SREKT-QQTKHq---------------------------------SPEQVWDPQPGP-- 372 coelacanth

EFN77420     339 -VKQSG-AGGTL-TPADRHGSVQVVSSTNGELANDDPTAGHSNTPI 381
7_pfamImport  44 -SKQGGhTLGNL-TPADRHGSVQVVSSTNGELANDDPTAGHSNTPI 87 
EDS32121     366 -PKQTGtLGNL--TPADRHGSVQVVSSTNGELNADDPTAGHSNTPI 408
EFX89320     358 --PGGNlLGGTL-TPADRHGSVQVVSSTNGDLGGDDP-AGHSHTPI 399
EEC11649     381 rQAGNTlLAEKLgQPGPPQGSVQVVSSTNGDLANDDPTTGHSNTPI 426
6_pfamImport  31 ----------SL-IPVHRN---QVVSSTNGELNTDEPTGAPSNIQL 62 
XP_007244372 383 -QTNLSyLSSYL-AADRHGGSAQVVSSTNGELNADDPLAAHSSAPI 426
XP_029702483 388 -QANSSyLTSHL-AADRHGGSVQVVSLTNGELNADDPLTAHSNAPi 431 torafugu
XP_029684726 375 -VTNKEtLGSHL-TAERLGGSVQVMSSTNGELNTDDPTAGHSNAPI 418 torafugu
XP_029684725 376 -VTNKEtLGSHL-TAERLGGSVQVMSSTNGELNTDDPTAGHSNAPI 419 torafugu
XP_005171263 379 -VTNRElLGSHL-TADRLGGSVQVMSSTNGEVNTDDPTAGHSNAPI 422 zebrafish
XP_005993849 373 -QSCREnMGAHL-AADRLGGSIQVMSSTNGELNTDDPTAGHSNAPI 416 coelacanth
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap