Conserved Protein Domain Family
Rhomboid_SP

?
pfam12595: Rhomboid_SP 
Rhomboid serine protease
This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.
Statistics
?
PSSM-Id: 403706
View PSSM: pfam12595
Aligned: 9 rows
Threshold Bit Score: 281.398
Threshold Setting Gi: 47214956
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q6PIX5        91 VSKDSDST-QKWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQK-------IIDPLARG 162 house mouse
XP_003964817  94 VSKDGDST-QRWQRKSLRHCSMRYGKLKPQVIREMDLPSQDNISLTSTETPPPLYVPASQHGMQK-------IVDPLARG 165 torafugu
3_pfamImport   1 VSKDSDST-QRWRRKSLQHCSHLYGGLKPQVMRDRELHSQDNISLASTETPPPLYLPPYHHGMQRvgkrrgqIVDPLARG 79 
XP_009304980  92 VSNDLDAT-QKWQRKSLRHCTQRYGKLKPQVIREMDLPSQDNLSMTSTETPPPLYVPPPHHGMQR-------IVDPLARG 163 zebrafish
XP_007482652  99 VSEDWDGKrQNWHRKSLHHCSMRYGKLKASCQRDLELPSQEVPSFQGTESPKACKLPK--------------IVDPLARG 164 gray short-tail...
XP_021397326  94 VSSDWEGKrQQWQRKSLQHCSMRYGKLKPA-YRDMELPSQEVPSFQATESPKPTKMPK--------------IVDPLARG 158 Bengalese finch
CAG10778      89 VGEDCESQqQVWHRKSLRHCSQRYGRLKAQ-YREPDTASSLEPGLD---SPGTHRLPK--------------IVDPLARG 150 spotted green p...
XP_011603031  91 VSKDSDST-QRWRRKSLQHCSHLYGGLKAQVMREMELRSQDNLSLASTETPPPLYLPPHHPsnrycg--mqrivDPLSRG 167 torafugu
XP_022522895  94 VSKDGDAT-QKWQRKSLRHCSMRYGKLKPQVIREMELPSQDNISLTSTETPPPLYVPSSQHGIPK-------IVDPLARG 165 Mexican tetra
Q6PIX5       163 RAFRMADDtAD-----GLSAPH---TPVTPGAASLCSFSSSRSGFNRLPRRRKRESVAKMSFRAAAALVKGRSIRDGTLR 234 house mouse
XP_003964817 166 RAFRMVEE-VD-----GYSVPQ---TPITPGATSLCSFTSSRSGLNRLPRRRKRESVAKMSFRAAAALVKGRSIRESTLR 236 torafugu
3_pfamImport  80 RAFRLVEE-VD-----GFSVPQ---TPITPGTASLCSLSSSRSALNWLPRRRKRESVAVMSLKAAAALMKGRPLADSTSG 150
XP_009304980 164 RAFRNVDE-VD-----GVNVPQ---TPITPCAASLCSFTSSRSGFNRPPRRRKRESVAKMGFRAAAALVKGRSLRDGAVR 234 zebrafish
XP_007482652 165 RAFRHPDE-VD-----RHHPPL---PPLTPGVLSLSSFTSVRSGYSHLP-RRKRMSVAQMSFHAAAAILKGRSVLEPAGQ 234 gray short-tail...
XP_021397326 159 RPFRHPDE-TD-----RPHTPHhvlPPLTPGVVSLASFNSIRSGYGRLP-RRKRESVAHMSFKAAAALLRGRSVLEPLAP 231 Bengalese finch
CAG10778     151 RAFRCPEE-MEprsprTPHVPQg--GPATPGVASLSSFTSQRSGFSRFP-RRKRESVARMSIRAASNLMRAS-------- 218 spotted green p...
XP_011603031 168 RAFRVVEE-AD-----GSSVPQ---TPVTPCTASLCSYSSSRSALNRLPRRRKRESVAVMSLKAAASLMKGRTLGGSTAH 238 torafugu
XP_022522895 166 RAFRMVEE-VD-----GYSVPQ---TPITPGAASLCSFTSSRSGLNRIPRRRKRESVAKMSFRAAAALVKGRSIRESTLR 236 Mexican tetra
Q6PIX5       235 RGQ---RRSFTPASFLEEDMVDFPDELDTSFFARE---GVlHEEMSTYPDEVFE-------------------------- 282 house mouse
XP_003964817 237 RAQ---RRSFTPASFMEEDIVDFPDELDTSFFARD---ILmHEELSTYADEVFE-------------------------- 284 torafugu
3_pfamImport 151 RPR---RRSFMPSSFLEDDTVDSTDELDTSFFTRE---GL-HDELYSYVDEVFE-------------------------- 197
XP_009304980 235 RLP---RRSFAAASFLDEDTVDFPDELDTSFFAKD---GVtHEELSTYADEVFE-------------------------- 282 zebrafish
XP_007482652 235 KRRv-iKRSFAYPSFHDEDVVDGADTFDSSFFSKI---DM--QEMYSMPDDVFE-------------------------- 282 gray short-tail...
XP_021397326 232 KRRs--KRSFLYPSFMDEDMVDAADTLDSSFFSKMdmhDE----TYSMPDDVFE-------------------------- 279 Bengalese finch
CAG10778     219 --RslpKRSFVRPSWVEEDTVDFAGISESVFFSKG---DA-HEELLSMADDVFE-------------------------- 266 spotted green p...
XP_011603031 239 RCR---RRSFMPPSFFEEDSVDFLDDLDTSFFNR-----------EGLHDELSSyaddvfetaseaalkqvdeseltgsa 304 torafugu
XP_022522895 237 RAH---RRSFTPASFIEEDVVDFPDELDTSFFARD---VLmQEEMSTFHDEVFE-------------------------- 284 Mexican tetra
Q6PIX5       283 ------------SPSEAALK--DWEKAPDQADLTGGALDR 308 house mouse
XP_003964817 285 ------------SPSEAALKvvESSGKKDETELTGSALDK 312 torafugu
3_pfamImport 198 ------------TPSEADLTq------lDESELTGGALDR 219
XP_009304980 283 ------------SPSEAAIKetDASRAGDERDLTGSALEK 310 zebrafish
XP_007482652 283 ------------SPPLSASYf--rGIPHSASPQTPeglhi 308 gray short-tailed opossum
XP_021397326 280 ------------SPPLSATYlrMHQVAEDAR-VSPEGVrl 306 Bengalese finch
CAG10778     267 ------------SPPLSAF-----------AAAAEPADQR 283 spotted green pufferfish
XP_011603031 305 ldkselershlmLPLERGWR---------------KAKDS 329 torafugu
XP_022522895 285 ------------SPSDSTTRd-vDSKQLDESELTGSALDK 311 Mexican tetra
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap