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Microcystin synthetase C terminal This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with pfam08242, pfam00501. There is a conserved YAN sequence motif. Microcystins form a large family of small cyclic heptapeptides harbouring extensive modifications in amino acid residue composition and functional group chemistry. These peptide hepatotoxins contain a range of non-proteinogenic amino acids and unusual peptide bonds, and are typically N-methylated. They are synthesized on large enzyme complexes consisting of non-ribosomal peptide synthetases and polyketide synthases. This family is made up of the C terminal of microcystin synthetase, one of the proteins involved in this synthesis pathway. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",