Conserved Protein Domain Family
WBS_methylT

?
pfam12589: WBS_methylT (492744 is an unknown moldel)
Methyltransferase involved in Williams-Beuren syndrome
This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.
Statistics
?
PSSM-Id: 492744
Aligned: 44 rows
Threshold Bit Score: 59.5763
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_001705075 196 LFSGh------------KPEQLPAALDGDDPTGDTea---qEQIGYSKVRQ---MSNa--eKRRAGGFLKgkkwq----- 250
2_pfamImport   1 LFCGv------------ASPTLPKALGTEEEAKKK------RQIKYVKERE---QRG----SDKRNKSIKk--------- 46 
XP_009011016 201 LYTGg------------APQAIPHGLGTEEANQRTv----qQQVVCASKRP---KYKd--lKGQSAKLS----------- 248
5_pfamImport   1 LFAGy-----------mEQQQIPQGLGTGAt---------aNQISYEGRAR---NQRq--rRGKGREPVKakyvmpqial 55 
Q55DA6       201 LFTG-------------NNNIMPSAKGVEGEEYEQqeeedsNEVKYSNRKR---DRRr--vTKSKGSAQHk--------- 253 Dictyostelium d...
XP_010759668 204 TVGG-------------------GGLQGDITGVVEg----mDDVDILDARKkamDGQskgrRRGVDPAHVk--------- 251
6_pfamImport   1 -FTGgtlvenqdskkkrKTYLILEMAGAKG-----------KSVHIREKKK---ARTf--kKPVANKDLS---------- 53 
XP_004365347 200 LFAG-------------VAAEVPKGLDGTEGEDGQa----gPSMPYSRKDR---DAHf--gKGKGKKAATk--------- 248
XP_025281595 269 LFSG-------------PSTFMPKPLNDSNESNEE------EEVQESVFTR---ERIp--yRIACRGVVRk--------- 315
4_pfamImport   1 LFAG-------------VTGVLPRGLGCETSDRTVq-----NQVQFSGQSR---SRF----KNLKGKSAKk--------- 46 
XP_001705075 251 ---------qpakfSREWKLHQVVKARLDGKDAKPVSRYSGRRRRG 287
2_pfamImport  47 --------------SRDWIIEKKERRKRQGKEVSINTKYTGRKRKP 78 
XP_009011016 249 --------------HREWLLEKKERRKRQGREVHPDSKYTGRKRAG 280
5_pfamImport  56 cwmancllicyccvSRDWVMAKKERYRKQGKKVKSDSKFTGRRRPG 101
Q55DA6       254 --------------TKEWIMNKKDRQRKQGREIKNDSKFSGRKRGP 285 Dictyostelium discoideum
XP_010759668 252 -------------gTKAWITRKKEQMERKGKIVKPTSKYTGRKRRI 284
6_pfamImport  54 --------------YRDWIIRKKAKREEKGLEVPRTSKYTGRRR-- 83 
XP_004365347 249 --------------SRDWIADKKERRKRQGKDVRPDSAYSGRSRGP 280
XP_025281595 316 --------------SREWVLEKKERRRRQGKEVRPDTQYTGRKRKP 347
4_pfamImport  47 --------------GKDWILEKKERRRRQGRDVRPDTKYTGRQRRP 78 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap