Conserved Protein Domain Family
WBS_methylT

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pfam12589: WBS_methylT 
Methyltransferase involved in Williams-Beuren syndrome
This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.
Statistics
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PSSM-Id: 403702
View PSSM: pfam12589
Aligned: 46 rows
Threshold Bit Score: 63.8018
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001705075 196 LFSGh---------KPEQLPAALDGDDPTGDTeAQEQIGYSKVRQ---MSNAE--KRRAGGFLkgkkwq----------- 250 Giardia lamblia...
2_pfamImport   1 LFAGy--------mEQQQIPQGLGTGA------TANQISYEGRAR---NQRQR--RGKGREPVkakyvmpqialcwmanc 61 
XP_010759668 204 TVGG----------------GGLQGDITGVVE-GMDDVDILDARKkamDGQSKgrRRGVDPAHvk--------------- 251 Paracoccidioide...
XP_004365347 200 LFAG----------VAAEVPKGLDGTEGEDGQ-AGPSMPYSRKDR---DAHFG--KGKGKKAAt---------------- 247 Capsaspora owcz...
EGD83075     201 LFAG----------VVGSVPAGKSDMMRDTAS--QSTVAYTRADR---RRQARrkKRAGVK------------------- 246 Salpingoeca ros...
EDV22658     200 LFTGq--------tAAAQLPQGL----DTTFSpIANVVQFTNERF---EFSGS--KNKLAAPAhar-------------- 248 Trichoplax adha...
ESO10747     201 LYTGg---------APQAIPHGLGTEEANQRT-VQQQVVCASKRP---KYKDL--KGQSAKLS----------------- 248 Helobdella robusta
1_pfamImport   1 LFAG----------VTGVLPRGLGCETSDRTV--QNQVQFSGQSR---SRF----KNLKGKSAk---------------- 45 
XP_002129806 202 LFCGv---------ASPTLPKALGTEEEAKKK---RQIKYVKERE---QRG----SDKRNKSIk---------------- 246 vase tunicate
ESS32074     297 LWVGgshlpgqqqqLQQLQAAALGADGP-------SQIESTRRER---QKQPR--RGKSSKATv---------------- 348 Toxoplasma gond...
XP_001705075 251 ---qpakfSREWKLHQVVKARLD-GK-DAKPVSRYSGRRRRG 287 Giardia lamblia ATCC 50803
2_pfamImport  62 llicyccvSRDWVMAKKERYRKQ-GK-KVKSDSKFTGRRRPG 101
XP_010759668 252 -------gTKAWITRKKEQMERK-GK-IVKPTSKYTGRKRRI 284 Paracoccidioides brasiliensis Pb18
XP_004365347 248 -------kSRDWIADKKERRKRQ-GK-DVRPDSAYSGRSRGP 280 Capsaspora owczarzaki ATCC 30864
EGD83075     247 --------SREWMMKKKESRRKKyGEnSVKRDSKFSGRKRPT 280 Salpingoeca rosetta
EDV22658     249 ------kkSRDWILHKKQRRRRQ-GF-EIRADSKYTGRRRKH 282 Trichoplax adhaerens
ESO10747     249 --------HREWLLEKKERRKRQ-GR-EVHPDSKYTGRKRAG 280 Helobdella robusta
1_pfamImport  46 -------kGKDWILEKKERRRRQ-GR-DVRPDTKYTGRQRRP 78 
XP_002129806 247 -------kSRDWIIEKKERRKRQ-GK-EVSINTKYTGRKRKP 279 vase tunicate
ESS32074     349 -------sRREWIEKKKERQRLQ-GK-KVRHQSKYTGRKRKD 381 Toxoplasma gondii VEG
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