Conserved Protein Domain Family
TPPII

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pfam12580: TPPII (This model is not part of the current CDD release)
Tripeptidyl peptidase II
This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. The family is found in association with pfam00082. Tripeptidyl peptidase II (TPPII) is a crucial component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It is an amino peptidase belonging to the subtilase family removing tripeptides from the free N terminus of oligopeptides.
Statistics
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PSSM-Id: 520344
Aligned: 45 rows
Threshold Bit Score: 192.409
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004343357 1023 SPLRRE-EVMPSITLKTWRQALKPGEYR----IAPLsTARDTLLDG-QRLYELVVSYKFSQA-DSMEVQITVPVVSDLLY 1095
XP_007875262  790 NTLAPE-IFEPTLKLNSLRRTFYPSFSS----IRPL-GERDVFPDS-KTLFEMILTYSLKFL-ENTEVTFFLP-LSSSLY 860 
XP_002682099  830 SSLRNM-EMNISAKLDSWKETLSPTNSEdsklIQIQnNPRNTYFDTeKCSYEMILDYNLKMA-SDHEIITSLPVLSKLLY 907 
Q9UT05        837 ASIRRE-NFKPDITLKDYVDSFKPTNTV----IKPL-GDRDIMPDG-QQLFELMATYSVEIS-EKTELKADFA-VPHNMY 907  Schizosacchar...
XP_002175998  670 FSLKKE-PFKPKVVFDRFSDSYRPVSAV----IKPL-KFRDVLPDG-QQLFETVITYKFDIK-EKTEVTLKFG-VPEHMY 740 
XP_001732379  811 SLVRCE-DLKPSASLDTRRTYVRPSKYV----LRPLrEPRDRQPSG-HQLHELVLEYPVIVK-DACALTWRLP-LSGYLY 882 
XP_018739161  806 NVLRLE-ECKPQATLETRRTYVRPTKHT----VRPRlEARDQQPSG-HALLELVAEYPVVVK-EAASLTWRVP-ISGYVY 877 
XP_006683005  817 APVRNE-SISPSISLDTLRKSIRPTDFT----ISPL-KSRDVLPDT-RQLHQLVLTYSTKIN-ESGSITPRFPRMNNMLY 888 
XP_067514993  786 APLRREdGLDVKVSFSKLRKYIRPAEST----ITPMhPCRDMLPSS-RVLYQLVLRYNFTID-SATTITARFPTVMNQLY 859 
XP_011386833  833 STVRIE-DFKPSITFDTRRTFHRPSSST----IRPLtTPRDLQPSG-NHMFELVTTYHISVKeDSNKLSYSFPALGNHLY 906  corn smut
XP_004343357 1096 ESPFEAQFWSVYDSNKRRLFSGDAFPSHYalKLD-KGDYVVRLQLRHEKIDVLERCKDFPVMIERSLTKsqEVSLDIFPS 1174
XP_007875262  861 DSSF-CMLTALFNRNKRLLHFGETEPIKT--KLK-AGEYVYRVQLVHDSILILEKVKNMTLSVIQSLGDskELSLNIFND 936 
XP_002682099  908 ECNIESRMLMIFNKNKKLVKVSDYHPEKF--KLK-KGDYVVRAQFRHDNIATLQKLKNYPLVITHVLAK--PISLKLFKH 982 
Q9UT05        908 DNGFNGLFFMVFDSQKQRVHYGDMYTSSH--TLE-KGEYLYKFQLLSVDPSTLERFRNVTLRLTKKLKK--PITLPLYAD 982  Schizosacchar...
XP_002175998  741 DNGFNGIFFMLFDAQKQLIHYGDMYPRPH--ELS-KGEYTVRLQLISVYTQVLETFKDVPLTLGRKLKK--EITLPLFAN 815 
XP_001732379  883 DASV-TLLTQLLDVNQAQVAFGDVYAKPV--DVA-KGEYTLRVQALHESAAVLDHLHAMPLSLEQKLKK--DISLDVYRD 956 
XP_018739161  878 DASV-TLLTQLLDKSHAQVAFGDVYPKAV--SLR-PGEYVLRVQALHESAAVLEKLRDMPVALDRKLKK--EIALDVYAD 951 
XP_006683005  889 DSSLENFGLFVFDSNKRTIAFRDIYPKAI--KAL-EGTYTFRAQVVSHSLDVLEKLQSMPLVLDIALSK--SVSLSIYNS 963 
XP_067514993  860 EHFLAGVFGIVYDTNRKVVGYLDVFDHNI--KLSqKGEYTIMLQLSTEEENVLEKLKDVICELDLDLKA---VNFNTFQN 934 
XP_011386833  907 DSSV-PLLTQLFDLRKKRVHFGDVYMKEI--DLP-KGDYVLKAQLLNESMKVLESLKNVTLMIDQKLSKpeSAALKLYDN 982  corn smut
XP_004343357 1175 YKAALANgARVRA--QTVAPGSILPCYIGcALPASRLPRDCR 1214
XP_007875262  937 HIDAFNK-EKSQDfnMKLQQGDRKSVVIStFIDPKQLPKDAK 977 
XP_002682099  983 INGALTD-VDKQDekFKLSYGRSNSYALGySGVEKDLPKEVK 1023
Q9UT05        983 HIDFCDNkTYER---ENIDAGVVESFVVGtNIEGEQYASELK 1021 Schizosaccharomyces pombe 972h-
XP_002175998  816 HIDFCDN-KKADYgnATIALDRPKSFIIGtDLSADIYPSDVN 856 
XP_001732379  957 HVDLQSH-VRPAKeaLKLHKGERAVLCIDtALHGERWPSDGV 997 
XP_018739161  952 HVDLFGA-APPRKdgIKLLQGERTVVVLDtSLAGESWPAEAA 992 
XP_006683005  964 LAGAISEdAAMSYkrKTLLRGQRSVFWVG-DIASNSVPKDAK 1004
XP_067514993  935 IADAYKN-GNSTLtkFNLERKNIKVLYIApPAGKDALPKDVK 975 
XP_011386833  983 HVDLHSEaPPAKYagVKLQPGERIVLTLDlNLEGDAVPKEAQ 1024 corn smut
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