Conserved Protein Domain Family
3-PAP
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pfam12578: 3-PAP (This model is not part of the current CDD release)
Myotubularin-associated protein
This domain family is found in eukaryotes, and is typically between 115 and 138 amino acids in length. Myotubularin is a dual-specific phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bisphosphate. 3-PAP is a catalytically inactive member of the myotubularin gene family, which coprecipitates lipid phosphatidylinositol 3-phosphate-3-phosphatase activity from lysates of human platelets.
Links
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Statistics
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PSSM-Id: 520342
Aligned: 22 rows
Threshold Bit Score: 102.837
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q3V1L6       549 RFSRQQQSLMVPGPPSsmwlfSRGTLTPLNQLCPWQDSSSLLAVSSHWLprPARSSESLAdqEWGLPSHWGACPLPP-GL 627 house mouse
A2BGG1       547 HQRQLSLPSSAFKTPT-------KKGFFKDETDSLKKMLRVKRISR-----WMGSPDSPVvaSREFYESWQQRPLDYhGL 614 zebrafish
EEC15212     505 ARRTRAYRNVWDWSGPesrlsAQDLELFQNPLYLLRRSRELLNAGRPVPppLPPSGSGDR----------RCAPSEDeDL 574
XP_006628855 566 RRAKKYHSSTMRGMP------SLRNGLMSEQDSIPRRNSLVLRLKPDFS--QLREPQDSP--SEQFFRDWLSRPPDLqGL 635
9_pfamImport   1 KRSKKNYSSTLRGVPT-----ALRNGVSNDHDTLPRRNSLMPRLRPDLA--QLREQQESP--AERFLQDWLSRPADPqGL 71 
XP_005467113 559 KRKPKAYSSTLRGPPT-----NLRNGVKGGEETLTRRSSLANELKSELT----PVKDESP--SERFFKDWFSRPADLqGL 627
A0JMF6       549 RRSKKNYSSTVRGLPS-----LMRNGSLGPNDTLTRRNSLVLRLRSDLS--QVREQPETP--SERFVRDFFSRAVDLqGL 619 zebrafish
XP_004017852 563 KRPKKSYSSTLRGMPA-----SLKNGIISEEELRPRRNSLILQVKPASL--EPRDSQDWD--AEQFFREWASRPADLhGT 633
XP_424996    547 HQRQLSLPLTQTKSSP-------KRGFFREETDHLIKNILGKRIGK-----FINSSDEPPnnFREFYDSWHSKPVDYhGL 614 chicken
NP_001281273 449 HQRQLSLPLTQSKSSP-------KRGFFREETDHLIKNLLGKRISK-----LINSSDELQdnFREFYDSWHSKSTDYhGL 516 human

Q3V1L6       628 LLPGYLGPQIRFWKRCYLRGRPEVQMGSSAL------------TVSALQDELSHLQELLRQWTPRISP 683 house mouse
A2BGG1       615 LLPSLDGPSVRIWMQRYLRWIPEVHIMGGGSvai-------mtKLMELLSQVEDLKRVLEQRDPSLAT 675 zebrafish
EEC15212     575 LSMDATVKALSVWTQCYFRWVPKAEVVNGDPgtlflhnvrvarDIQFLAAQVR----LLREHRRDGVE 638
XP_006628855 636 LLPQLLPSHIKLWKLYFLRWIPEAQINGGGFita-------fhKVSLLADEIEKLQNQLRQYKGNPCP 696
9_pfamImport  72 LLPQLLPSHLPLWKLYFLRWVPEARIPHGGPvta-------fhKLSVLADEIEMLQNQLRQYNGGATP 132
XP_005467113 628 LIPLLMPSHMAFWKLFFLRWVPEACISKGGPvtt-------yhKLSQLVDEIEILQSQLRQYKGTSPG 688
A0JMF6       620 LLPQLLPSHLSVWKLYFLRWVPEAQIPHGGPvta-------fhKLSVLTDEIEMLQNQLRQYKGAAGT 680 zebrafish
XP_004017852 634 ILPHLSGAHIKLWKLCYFRWVPEAQIQHGGFitv-------fhKLSLLADEVDVLSRALRQPRGGPMP 694
XP_424996    615 LLPRIDGPEIKVWAQRYLRWIPEAQLHGGGTiat-------aaKILDLMEEVQNLQVKMDEEHSQAVS 675 chicken
NP_001281273 517 LLPHIEGPEIKVWAQRYLRWIPEAQILGGGQvat-------lsKLLEMMEEVQSLQEKIDERHHSQQa 577 human
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