Conserved Protein Domain Family
3-PAP

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pfam12578: 3-PAP 
Myotubularin-associated protein
This domain family is found in eukaryotes, and is typically between 115 and 138 amino acids in length. Myotubularin is a dual-specific phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bisphosphate. 3-PAP is a catalytically inactive member of the myotubularin gene family, which coprecipitates lipid phosphatidylinositol 3-phosphate-3-phosphatase activity from lysates of human platelets.
Statistics
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PSSM-Id: 403693
View PSSM: pfam12578
Aligned: 24 rows
Threshold Bit Score: 93.997
Threshold Setting Gi: 123785603
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q3V1L6       553 QQQSLMVPGPPSsmwlfSRGTLTPLNQLCPWQDSSSLLAVSSHWLprPARSSESLAdqEWGLPSHWGACPLPP-GLLLPG 631 house mouse
EEC15212     509 RAYRNVWDWSGPesrlsAQDLELFQNPLYLLRRSRELLNAGRPVPppLPPSGSGDR----------RCAPSEDeDLLSMD 578 black-legged tick
A2BGG1       551 LSLPSSAFKTPT-------KKGFFKDETDSLKKMLRVKRISR-----WMGSPDSPVvaSREFYESWQQRPLDYhGLLLPS 618 zebrafish
XP_006628855 570 KYHSSTMRGMP------SLRNGLMSEQDSIPRRNSLVLRLKPDFS--QLREPQDSP--SEQFFRDWLSRPPDLqGLLLPQ 639 spotted gar
XP_022520842 567 KNYSSTLRGVPT-----ALRNGVSNDHDTLPRRNSLMPRLRPDLA--QLREQQESP--AERFLQDWLSRPADPqGLLLPQ 637 Mexican tetra
XP_005467113 563 KAYSSTLRGPPT-----NLRNGVKGGEETLTRRSSLANELKSELT----PVKDESP--SERFFKDWFSRPADLqGLLIPL 631 Nile tilapia
A0JMF6       553 KNYSSTVRGLPS-----LMRNGSLGPNDTLTRRNSLVLRLRSDLS--QVREQPETP--SERFVRDFFSRAVDLqGLLLPQ 623 zebrafish
KFV43849     226 LSLPLTQTKPST-------KRGFFREETDHLIKNILGKRIGK-----FINSSDEPPnsFREFYDSWHSKPIDYhGLLLPR 293 red-throated loon
CAH10604     210 LSLPLTQSKSSP-------KRGFFREETDHLIKNLLGKRISK-----LINSSDELQdnFREFYDSWHSKSTDYhGLLLPH 277 human
XP_319467    527 AALTVPSASSSSsspqnPIQNSLFNARRAEDSNGQTIVNVVGKL--------------QLYFFPLNLVFNQNNeQFLEPQ 592 Anopheles gambi...
Q3V1L6       632 YLGPQIRFWKRCYLRGRPEVQMGSSAL------------TVSALQDELSHLQELLRQWTPRISP 683 house mouse
EEC15212     579 ATVKALSVWTQCYFRWVPKAEVVNGDPgtlflhnvrvarDIQFLAAQVR----LLREHRRDGVE 638 black-legged tick
A2BGG1       619 LDGPSVRIWMQRYLRWIPEVHIMGGGSvai-------mtKLMELLSQVEDLKRVLEQRDPSLAT 675 zebrafish
XP_006628855 640 LLPSHIKLWKLYFLRWIPEAQINGGGFita-------fhKVSLLADEIEKLQNQLRQYKGNPCP 696 spotted gar
XP_022520842 638 LLPSHLPLWKLYFLRWVPEARIPHGGPvta-------fhKLSVLADEIEMLQNQLRQYNGGAtp 694 Mexican tetra
XP_005467113 632 LMPSHMAFWKLFFLRWVPEACISKGGPvtt-------yhKLSQLVDEIEILQSQLRQYKGTSPG 688 Nile tilapia
A0JMF6       624 LLPSHLSVWKLYFLRWVPEAQIPHGGPvta-------fhKLSVLTDEIEMLQNQLRQYKGAAGT 680 zebrafish
KFV43849     294 VDGPEIKVWAQRYLRWIPEAQLHGGGTiat-------aaKILDLMEEVQSLQVKMDEEHSQAI- 349 red-throated loon
CAH10604     278 IEGPEIKVWAQRYLRWIPEAQILGGGQvat-------lsKLLEMMEEVQSLQEKIDERHHSQQa 334 human
XP_319467    593 CCLRDIELWQQCYFRWMPHLEIKYGGMaqcdlfnrillnNIFKLRQNLD---------QSVLSE 647 Anopheles gambiae str. PEST
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