Conserved Protein Domain Family
PPARgamma_N

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pfam12577: PPARgamma_N 
PPAR gamma N-terminal region
Peroxisome proliferator-activated receptors (PPAR) are nuclear hormone receptors that control the expression of genes involved in lipid homeostasis in mammals. This sequence region is found at the N-terminus of these proteins. The family is found in association with pfam00104, pfam00105. It is not clear if this region is a separate protein domain.
Statistics
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PSSM-Id: 403692
View PSSM: pfam12577
Aligned: 9 rows
Threshold Bit Score: 115.661
Threshold Setting Gi: 819328158
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003462784   1 MVDT-EMPFW-PTNFGLSSMDLSVMDDHSHSFDIKPFTTVDF----------------------SSIS------------ 44  domestic guinea...
XP_006004475   1 MVDT-QMPLW-SMNFGLSSVDLTDLDDHSHSFDIKPFTTVDF----------------------SSIS------------ 44  coelacanth
XP_006631094  23 MVDT-QMPVW-PMNFGLNAVDLADLDDSSQSFDMKPFTTVDY----------------------SSIS------------ 66  spotted gar
AKG51674       1 MVDTqQLLAW-PVGFSLSTVDLPEFNDSSHCLDMKHLSTSDY----------------------ASISsssipsslsppl 57  Chinese medaka
XP_012810576   1 MVDT-EMPFWsSLSFGMNAME--ALEEHCQPYDIKPFATVDF----------------------SSIN------------ 43  tropical clawed...
POI35150       1 MVDT-EMPFW-PVNFGISPVDLSAMDDHMHSFDIKPFTTVDF----------------------SSIS------------ 44  Chinese bamboo-...
XP_003217721   1 MVDT-EMPFW-PMNFGISPVDLSAMDEHSHSFDIKPFTTVDF----------------------SSLS------------ 44  green anole
KAA8593290     1 MVDTqQLLAW-PVGFSLSAVDLSELDDSSHSLDMKHLSTLDYasissssipsslspplvssissA--------------- 64  orangethroat da...
CAG07050      46 MVDTqQLLAW-PVGFSLNSMDLPELYDHPHSLDMKHLTTLDY----------------------TSISssstqssmspsf 102 spotted green p...
XP_003462784  45 -------TPHYEDIP-----FPRVDPMVADY--KYDLKLQe-yQNAIK 77  domestic guinea pig
XP_006004475  45 -------SMHYEHSP-----LSGIDQTTTDY--EYDLRIPe-yQYAVK 77  coelacanth
XP_006631094  67 -------SLAYETSP-----LPSEDLAQFDY--MYDFKMNe-nPNTIK 99  spotted gar
AKG51674      58 vssmsstGMAYDPSPp----QSEDHLTNMDYtnLHSYRTEldthSSVK 101 Chinese medaka
XP_012810576  44 -------S-HYEDILdektfLCRGEQSPIDY--KYDLKLQe-cQSSIK 80  tropical clawed frog
POI35150      45 -------SPHYEDIP-----LGRADQTSIDY--KYDIKLQd-cQSAIK 77  Chinese bamboo-partridge
XP_003217721  45 -------SPHYEDLA-----LARTDQMAIDY--KYDVKFQe-cQNTIK 77  green anole
KAA8593290    65 -------GVAYDPSPp----QNDEQLTNMDFtnMHSYRMEpdthNLIK 101 orangethroat darter
CAG07050     103 vacisptDMGYDPSPp----LSEEHMTGMDYlnMHGC-------NSIK 139 spotted green pufferfish
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