pfam12573: OxoDH_E1alpha_N (This model is not part of the current CDD release)
2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal
This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with pfam00676. There are two conserved sequence motifs: VPEP and RPG. This family is the alpha subunit of the E1 component of 2-oxoisovalerate dehydrogenase. This is the enzyme complex responsible for metabolism of pyruvate, 2-oxoglutarate, branched chain 2-oxo acids and acetoin. The E1 component is a heterotetramer of alpha2beta2. The homodimerized beta subunits are flanked by two alpha subunits in a 'vise' structure.
Jiyao W et al.(2023). "The conserved domain database in 2023.",