Conserved Protein Domain Family
CD45
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pfam12567: CD45 (This model is not part of the current CDD release)
Leukocyte receptor CD45
This family of proteins is found in eukaryotes. Proteins in this family are typically between 77 and 1130 amino acids in length. The family is found in association with pfam00041. CD45 plays a critical role in T-cell receptor (TCR)-mediated signaling. CD45 interacts with SKAP55 which is a transcriptional activator of IL-2.
Links
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Statistics
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PSSM-Id: 492725
Aligned: 14 rows
Threshold Bit Score: 65.1101
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005608102  172 VNYSYNHANQSYDAKLNVTDEVECNSTepngyisCVNNMFHGLPECKIF-TVRIYHNSCSSYKEFK 236 
XP_027630350  238 VGYEYDYINHTYSATLNATETVECQPE-------CINNTVHGLKECENI-DISISHTSCAFPNKIV 295 
XP_023370328  109 VDYNYDSTKKSFTAKLNVNDKVECSGFv-----nCTNNEFHNLQQCTSF-TVNITHHTCAGPPKQL 168 
XP_008266916  237 VEYTQIKENESITAKLKVQEEVECSPLi------CKNNSLH-LQGCEQI-SINISHNSCVSPPKSL 294 
XP_030674554  282 VDYLYNKETKEFMAKLNVNEKVECGNNn------CTNNEVHKLAECKEI-NVSISHNSCTSYKELK 340 
1_pfamImport    1 VDYLYNKETKLFMAKLNVNETVECEKNn------CINNELHNLKECEN--SLSIFHNSCTAPYRKL 58  
XP_011217208  231 VEYHYDNKDGSYKAKLNVSDQVNCEKAt------CSKNEILNLTECENK-NVTISHNSCGTPNKIL 289 
XP_013013472  238 VEYKYDSRTKLFTANLLGADSVKCHSPe------CEK-TLQGLHECSHV-TVLIGDGNCSSPIHLQ 295 
NP_001255215   49 VNYTYESSNQTFKADLKDVQNAKCGNEd------CEN-VLNNLEECSQIkNISVSNDSCA-PATTI 106 
EGW06747       75 VYYDYNSNKKSFEAKLKGDKNPQCEAAd------CEK--LKNLQECSQS-NFTVSNGSCI-PHKII 130
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