Conserved Protein Domain Family
Inhibitor_I10

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pfam12559: Inhibitor_I10 
Serine endopeptidase inhibitors
This family includes both microviridins and marinostatins. It seems likely that in both cases it is the C-terminus which becomes the active inhibitor after post-translational modifications of the full length, pre-peptide. it is the ester linkages within the key, 12-residue. region that circularize the molecule giving it its inhibitory conformation.
Statistics
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PSSM-Id: 372187
View PSSM: pfam12559
Aligned: 5 rows
Threshold Bit Score: 55.8259
Threshold Setting Gi: 503089940
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Riv7116_3458   1 MSEKENKKINSNAVPFFARYLEGQY-CEDLSEEEMDRVHGGLSKRekiskrypndlkdivtTMKYPSDHED 70  Rivularia sp. PCC 7116
Q8YLC2             1 MPENRQEDLNAQAVPFFARFLEGQN-CEDLTDEESEAVSGGKRGQ----------------TRKYPSDCED 54  Nostoc sp. PCC 7120
WP_013324783       1 MSNNAAALPITNAKPFFARFLATQE--ETPPTEKPAETPAPfpfpe----------fppifTLKFPSDWED 59  Gloeothece verrucosa
jgi:Cha6605_0864  43 TNDSAEKNL-----PFFARFLEGQH--PEVVDNKVALTESSTIQTqplnslsdlgkkgtvtTRKYPSDAED 106 Chamaesiphon minutus...
WP_012625819       1 MSDINKQDASAKAVPFFARYLEEQEvSQELSQEELEGLSGAr------------------tTLKYPSDSDE 53  Cyanothece sp. PCC 7425
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