6L82


Conserved Protein Domain Family
MOZART1

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pfam12554: MOZART1 (This model is not part of the current CDD release)
Mitotic-spindle organizing gamma-tubulin ring associated
The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, this family does not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. MOZART1 is required for gamma-TuRC recruitment to centrosomes.
Statistics
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PSSM-Id: 520332
Aligned: 53 rows
Threshold Bit Score: 44.7816
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6L82_B        20 VDILHEIATILNCH-LDRRTLSICISMIENG-VNPEALANVIKEL 62  Thermochaetoides thermophila DSM 1495
XP_002065642  30 MEILYGMSTLINTR-LSKEALILCIELLEVG-VNAKVLAQVVLKI 72 
5_pfamImport   4 RTSIQGISQLLNTG-LDSYSLELCMKLLEAG-IHPQALADVVNEI 46 
4_pfamImport   4 RANIQNISQFLNTG-LSPETLDICVKLLEAG-VHPQSLSEAVIQI 46 
EDS29242      43 RANIQNISQLLNTG-LTPEALDICVKLLEAG-VHPQALAEVVTQI 85 
XP_070063694 186 RIAVHGMSELINTR-LSTEALEICLELIEAG-VQPRALAEVVLHI 228
XP_001993707  45 RIAVHGMSSLINTR-LSSEALQTCLALIEAG-VHSKALADIVMHI 87 
XP_006957253  18 LENLFELSQTLNTG-LSKETLSNSLELIDDG-LDPSTLADVILAL 60 
XP_029837533  31 FEVLQEMSQLLNTG-LSPEALAVCVQLCERGaADPRSLANLVNGL 74 
Q6BS15        20 NSLLIELADLLNIKeIDDTTLQVCIKLIDQG-IDPQQLATYILKI 63  Debaryomyces hansenii
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