Conserved Protein Domain Family
ATXN-1_C

?
pfam12547: ATXN-1_C 
Capicua transcriptional repressor modulator
This family of proteins is found in eukaryotes. Proteins in this family are typically between 49 and 781 amino acids in length. There is a conserved IQT sequence motif. ATXN1 directly binds Capicua and modulates Capicua repressor activity in Drosophila and mammalian cells. The polyglutamine expanded mutant type of ATXN-1 does not bind Capicua with as high affinity as wild-type ATXN-1. It is associated with spinocerebellar ataxia type 1 (SCA1).
Statistics
?
PSSM-Id: 403666
View PSSM: pfam12547
Aligned: 4 rows
Threshold Bit Score: 43.929
Threshold Setting Gi: 123888230
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_005797508 339 MGKPVSRPPSSSnttcsftfPPP-LSADSLKAaVSTLPPQTVIQTTHNASEQLS 391 southern platyfish
XP_006002926 387 LGKHVPRSYALS--------PPQtLGPDSVKA-VATLSPHTVIHTTHSASEHLP 431 coelacanth
XP_015212340 383 LGKPVARASSFTlss---ssSSShLGADGLKAtVTTLSPHTVIHTTHNATEQVS 433 spotted gar
Q1L966       357 AGKPVSRSSSLSssls-falPPPpV--DNLKGaVPAQSPHAVIQTTLNSTESLS 407 zebrafish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap