Conserved Protein Domain Family
CWC25

?
pfam12542: CWC25 
Pre-mRNA splicing factor
This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with pfam10197. There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.
Statistics
?
PSSM-Id: 403663
View PSSM: pfam12542
Aligned: 113 rows
Threshold Bit Score: 28.5719
Threshold Setting Gi: 459367386
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
KJE93312      67 AQRLEWMYT---------GQa--V---AASRqqEEYLLGKR-Vs----------dTTSAGAPasslsqasgvagslfvga 121 Capsaspora owcz...
XP_007375454  74 LSKLNWMYEdvp---feeKEeevkndagFIEssNEFTEGKSkVenllk---gnhsFKRTiqssssd-------------- 133 Spathaspora pas...
XP_001524861  74 VSKLSWMYEdvp----feKPtettnssgFIEsnQEFVEGKAeVenmln---gkiaMKRNKGN------------------ 128 Lodderomyces el...
CCE43994      74 VSKLSWMYEdvp---fekQEtetmsssgFIEttTEFTEGKTeAenlls---gnraFKKH--------------------- 126 Candida parapsi...
Q59LQ5        74 ISKLNWMYDdvpfegnekVEensS---GFIEsnVEFTDGKSkVenllk--gnhvvGKKRdgsgtsd-------------- 134 Candida albican...
EER31009      74 LSKLNWMYDdvp---fenNEqveenssgFIEssLEFTEGKSkVenmln--gnnnmVSRK--------------------- 127 Candida tropica...
EMG46424      74 LSKLNWMYDdvp---fenNEqveenssgFIEssLEFTEGKSkVenlln---gnraISRK--------------------- 126 Candida maltosa...
EEQ38493      72 LNKLSWMYEdv-----gnTKepkvneagFREveEDFLKDKDeVerllk---gsgaMKKKpvsrf---------------- 127 Clavispora lusi...
EFC37704      26 RKQIEWMYNkdy-------------dkvNEEslEEYLVGKKsIeklvq--ggdlvDNDYKI------------------- 71  Naegleria gruberi
CAR23914      66 KNGMEWMYNdp---------------aaTNEqnTDFLLGKKrIdtsilkkneqpyTQKKD-------------------- 110 Lachancea therm...
KJE93312     122 gagagagaggsaggagksglpAQSGavqgslaaitqvapSALDMANK---------------IREDPMYLIKKKEQESLQ 186 Capsaspora owcz...
XP_007375454 134 --------------------------------rlnkvigVGISKPSGss------------dLSDDPLLRIKQQQQLQRM 169 Spathaspora pas...
XP_001524861 129 ---------------------NEGRneaggsermnkilsVGITGNNSgknmnkindaknlrsYGDDPLAMIKQQQQQQQQ 187 Lodderomyces el...
CCE43994     127 ------------------------DtngfanermnkvigTGSKKPNSt-------------nYGDDPLAMIQKQQVGQQR 169 Candida parapsi...
Q59LQ5       135 --------------------------------rinkiigVGMTKSSKv-------------sYSDDPLLKIKQQQQQAQR 169 Candida albican...
EER31009     128 ------------------------RdrgdhsdrinkiigVGMSKPQKtt------------sYSDDPLAKIKQQQQQQQQ 171 Candida tropica...
EMG46424     127 ------------------------RsgndssdrinkiigVGMSKSSKst------------tYSDDPLAKIKQKQKQQQA 170 Candida maltosa...
EEQ38493     128 ----------------------------------dqvtkVGSTQKVSs--------------LDDDPLLKIQREQLRKRV 159 Clavispora lusi...
EFC37704      72 -----------------------MLeqkkagalflhsheNRHHSGEA---------------IIDDPMIKIKHESLMRMK 113 Naegleria gruberi
CAR23914     111 ------------------------RhfdtsnkgihsileNKRPAASTd-------------lSRDDPLAAFQKAQEIRRN 153 Lachancea therm...
KJE93312     187 ALLSNP 192 Capsaspora owczarzaki ATCC 30864
XP_007375454 170 NQKKhd 175 Spathaspora passalidarum NRRL Y-27907
XP_001524861 188 QQKQKq 193 Lodderomyces elongisporus NRRL YB-4239
CCE43994     170 lkqrdt 175 Candida parapsilosis
Q59LQ5       170 VARKQh 175 Candida albicans SC5314
EER31009     172 AQRSsr 177 Candida tropicalis MYA-3404
EMG46424     171 lksaks 176 Candida maltosa Xu316
EEQ38493     160 DHREre 165 Clavispora lusitaniae ATCC 42720
EFC37704     114 MYLQNP 119 Naegleria gruberi
CAR23914     154 TARsdr 159 Lachancea thermotolerans CBS 6340
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap