Conserved Protein Domain Family
Pannexin_like

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pfam12534: Pannexin_like (This model is not part of the current CDD release)
Pannexin-like TM region of LRRC8
Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.
Statistics
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PSSM-Id: 520318
Aligned: 39 rows
Threshold Bit Score: 385.434
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_023414199   1 MFTLAEVASLN-DIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVV-CLPVLPSpvnskahtspgnadvttd 78 
9_pfamImport   1 MIPVGEFRSLGtEPNSKYRVLKPWWDVFTEYLCIAMLMIGVFGCTLQLTQDKIA-CLPSHFT------------------ 61 
XP_011611391  60 MIPVGEFRNFStEQNTKLRVLKPWWDVFTEYLCVAMVMIGVFGCTLQLTQDKIA-CLPSHYT------------------ 120
3_pfamImport   1 MIPVGEFRNFGaEQNSKYRVLKPWWDVFSEYLCVAMLMIGVFGCTLQLTQDKIS-CLPSPFT------------------ 61 
XP_005801058   1 MIPITELRYFV-DTQPAYRILKPWWDVFTDYISIVMLMISVFGGTLQITQDKMI-CLPCK-------------------- 58 
XP_027326473   1 MIPVTELRYFA-DTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMI-CLPCK-------------------- 58 
XP_030134981   1 MITLTELKCLA-DAQSSYHILKPWWDVFWYYLTMIMLLVAVLAGALQLTQTRVLcCLPC--------------------- 58 
NP_001100674   1 MITLTELKCLA-DAQSSYHILKPWWDVFWYYLTLIMLLVAVLAGALQLTQSRVLcCLPC--------------------- 58 
XP_056671351   1 MLSLSELKYIA-DAQSSYHILKPWWDVFWYYLTLIMLLVAVLSGALQLADTKLLcCLPC--------------------- 58  gray short-tail...
XP_064416159   1 MFTVTELKHFS-DTQAAYHILKPWWDVLCHYISMVMLLIAVLGGALQFSQSKLL-CLPC--------------------- 57  coelacanth
XP_023414199  79 ipkieaatdrdrdgqaangisfgtsavtpdipLRATYPRTDPTVPSQEAR--------------KEKkDPTGRKTNLDFQ 144
9_pfamImport  62 --------------------------------SPTPKAIDCSNISGYGDNeklqhtl-vtpaspIIV-EVFGRKNNLDIH 107
XP_011611391 121 --------------------------------SPTPEAIDCSHIRHYGDNrtalak----pvnaviS-EVFGRKNGLDIH 163
3_pfamImport  62 --------------------------------SKTPEAIDCSYIRTYRDNetsqrtv-dppakpEIR-EVFGRKNNLDIP 107
XP_005801058  59 ---------------------------------WIVNETCKKNlsst-------------lstsFLL-EPKGIQYNLDRH 91 
XP_027326473  59 ---------------------------------WVTKDSCNDSVRGWTAAapertyfnsslvpsADT-GPTGIRYDLDRH 104
XP_030134981  59 -----------------------------------KLEFDNHCAVPWDLVkanlnm--stsstaPII-IPLKIQNYLHRQ 100
NP_001100674  59 -----------------------------------KVEFDNHCAVPWDLLkasent--ssnsglPLP-LPLRIQNDLHRQ 100
XP_056671351  59 -----------------------------------KVELNNRCVVPWDMLklnstp---snpllPVT-PPIRIQNDLHKQ 99  gray short-tail...
XP_064416159  58 -----------------------------------KLTRDKNCTVAWDFGdtissv--qsetivNVT-LPNGITNYLDRQ 99  coelacanth
XP_023414199 145 QYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEEN 224
9_pfamImport 108 QYVFVNNYCYERSVHWYAKYFPYLVVIHTIIFMVTSSFWFKFPGTSSKIDLFVNILEKCFDSPWTTRALSEVSEERGEEK 187
XP_011611391 164 QYVFVNHYCYEKSVHWYAKFFPYLVLIHTMVFMVASGFWFKFPGTSSKIDLFVNILAKCFDSPWTTRALSEVSEERGEEK 243
3_pfamImport 108 QYVFVNHYCYEKYVHWFAKFFPYLVVIHTMIFMVASSFWFKFPGTSSKLDLFVTILGKCFDSPWTTRALSEVSEERGEEK 187
XP_005801058  92 QYNYVDAVCYENKLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEESDPK 171
XP_027326473 105 QYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEESDTK 184
XP_030134981 101 QYSYIDAVCYERQLHWFAKFFPYLVLLHTFIFAACSNFWLYYPSTSSRLEHFVAVLQKCFDSPWTTRALSETVAEQSARK 180
NP_001100674 101 QYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVSILHKCFDSPWTTRALSETVAEQSVRP 180
XP_056671351 100 QYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVSILNKCFDSPWTTRALSETVAEQSVR- 178 gray short-tail...
XP_064416159 100 QYSYVDAVCYEKQLHWFAKFFPYLVLLQTFIFVICGNFWLKFPSTSSRLEHFVAILHKCFDSPWTTRSLSETVAEQRSEK 179 coelacanth
XP_023414199 225 KQRITGAQTLpkhvsT---SSDEGSPSASTPMINKTGFKFSAEKPVIEVPS-MTILDKKDGEQAKALFEKVRKFRAHVED 300
9_pfamImport 188 LVNWRRNTMTkg------sTERQMDEEETVGLLRSCSVKSNQEKKSAEPKStPSLLDKKEGEQAKALFEKVKKLRTHVEE 261
XP_011611391 244 LVSWRRNTVSk--------SAEKAEDEETVGLMRSSSVKSNPEKKNLEAQPpPSVLDKKEGEQAKALFEKVKKLRTHVEE 315
3_pfamImport 188 LVSWRRNTMS-----KdstDRRAEDEEASVLLLRSSSVKSNPEKKLPEIQSpASVLDKKEGEQAKALFEKVKKFRTHVEE 262
XP_005801058 172 PM--KMNGSFd-------hKESVISEDVEASVPMIQKTKTRFEQGIVD-RTeTGVLDKKEGEQAKALFEKVKKFRIHVEE 241
XP_027326473 185 PAFGKMNGSMd-------kKSSTVSEDVEATVPMLQRTKSRIEQGIVD-RSeTGVLDKKEGEQAKALFEKVKKFRTHVEE 256
XP_030134981 181 LPIAKSKTVI---------SSPQSSGDIGASRQSLPYSQHGLETTGREn---SSVLDKKEGEQAKAIFEKVKKFRVHAEE 248
NP_001100674 181 LKLSKSKTLL---------STSGGSADIDASKQSLPYPQPGLESPGIE-SPtSSVLDKKEGEQAKAIFEKVKRFRLHVEQ 250
XP_056671351 179 VPLSKSKALF---------SPSGLSTNISASKQSLLFAQSGLDS-GIE-SPtSSVLDKKEGEQAKAIFEKVKRFRLHVEQ 247 gray short-tail...
XP_064416159 180 LSFSKSSNLL-----------GFSTTDVESSKSLISHAQIGPEIKAVD-TTiSKVLDKREGEQAKAIFEKVKKFRMHVEE 247 coelacanth
XP_023414199 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLTGYEVFECTHNMAYMLKKLLISYISIICVYGFIC 380
9_pfamImport 262 KDILYHMYVLQTSVKVIHFLLIIIYTALLVPNIEIVVQCLVP-PELTGFDIYCCNHNKAHLFSKLAYCYICFVAVFGLLR 340
XP_011611391 316 ADLLYFMYVLQTCLKVFKFLLIIIYTAVLVPNIEIVVRCLVP-PELTGFDIYCCNHNKANLFSKLAYCYVSFVGVYGLLC 394
3_pfamImport 263 ADLLYVMYVLQTSLKVFKFLVIIIYTSVLVPNIEIIVRCYIP-PELTGFDIYCCNHNKAHLFSKLAYCYICFVGVYGILC 341
XP_005801058 242 GDIVYRLYIRQTIIKVIKFILIICYTGYYVQDIQFNVDCSVNIENLTGYRVYHCAHPLATLFKILACFYICLVVVYGLIC 321
XP_027326473 257 GDIVYRLYMRQTIIKVIKFILIICYTVYYVNNITFDVDCKVDIESLTGYRMYRCAHPLATLFKILASFYISLVIVYGLIC 336
XP_030134981 249 KDVVYTVYMKQIIVKVFVVVIIVIYVPYYLSFITLEIDCVVNVQAFTGYKRYQCVYSLAEIFKVLASFYVVLVIFYGLTC 328
NP_001100674 251 RDIIYRVYLKQIIVKVILFVLIITYVPYFLSYITLEIDCSIDVQAFTGYKRYQCVYSLAEIFKVLASFYVILVMLYGLTS 330
XP_056671351 248 KDIIYRVYMRQIIIKVILFVIIIAYVPYFLTYITLEIDCPIDMQAFTGYKRYHCVYSLAEIFQVLASFYVIMVLFYGLTS 327 gray short-tail...
XP_064416159 248 KDIIYKLYMKQIIAKIEALpdslfqcknlqylllgrnslstlspqicelvnlikleltgnqlellpvelercrrlkssgl 327 coelacanth
XP_023414199 381 LYTL 384
9_pfamImport 341 IYTL 344
XP_011611391 395 VYSL 398
3_pfamImport 342 IYTL 345
XP_005801058 322 MYTL 325
XP_027326473 337 MYTL 340
XP_030134981 329 TYSL 332
NP_001100674 331 SYSL 334
XP_056671351 328 SYSL 331 gray short-tailed opossum
XP_064416159 328 ivee 331 coelacanth
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