Conserved Protein Domain Family
Neuro_bHLH
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pfam12533: Neuro_bHLH (This model is not part of the current CDD release)
Neuronal helix-loop-helix transcription factor
This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found C-terminal to pfam00010. There is a single completely conserved residue W that may be functionally important. Neuronal basic helix-loop-helix (bHLH) transcription factors such as neuroD and neurogenin have been shown to play important roles in neuronal development.
Links
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Statistics
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PSSM-Id: 520317
Aligned: 33 rows
Threshold Bit Score: 70.0586
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003222489  172 GKRPDLVAYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQ-GPDLGGRyhg-gpgGG-GGGFGVgphhPYG-YPCA---- 243
XP_030846597  144 GVVPDNISFAQTLSRGLSQPTTNLVAGAMQLNPRTLLPDD-QTSPYSAwpssapmNGmTDSYGYdlsnTSShHRLGe--- 219
Q6NYU3        147 GKRPDLLTFVQTLCKGLSQPTTNLVAGCLQLNARNFIPDQiSGEASF--------SG-RSPYES----VYStYHSP---- 209 zebrafish
Q9W6C7        137 GKRPDLLAFVQTLCKGLSQPTTNLVAGCLQLNARNFLTDH-NGDVSf--------SG-RPAYDS----LYP-YPNA---- 197 zebrafish
10_pfamImport   1 GKRPDLLAFVQTLCKGLSQPTTNLVAGCLQLNARNFLTDH-NGEASH--------SG-RSPYDS----VFPpYQSP---- 62 
8_pfamImport    1 GKRPDLLSFVHTLCKGLSQPTTNLVAGCLQLNARSFVGEP-GADSSFP-------ST-RSPYDA----VYAaYHGH---- 63 
XP_005462360  148 GKRLDLLTFVQTLCKGLSQPTTNLVAGCLQLNTCSVISQP-DEESLSL-------YA-----------AYHhHPGP---- 204
XP_022534450  130 GTRPDLLAFARTLCAGLSQPTTNLVAGCLQLNAARFLADHgGGGIG---------EG-EAQYDV----AYGaTPTGhahh 195
XP_002642781   78 NEQPTPLEYAHTLANGLSQTTTNMLANLLQVQPRHLLPPS----------------------------QFDmFSDA---- 125
EGT45690       78 NEQPTPLQYAHTLANGLSQTTTNMLANLLQVQPRLLLPPS----------------------------QFDmFSDP---- 125

XP_003222489  244 RLSGAQ-CGGGGGGggggssSSHALR-THA-YCAasyeALYg-GNASP--DYNSSEYEG-PLSp-pPPLCVNGNFS 311
XP_030846597  220 NMTSTG-ISNGGPS------SIHQLFlPSDgYCS-----------SPP--DLYHRQYD--PSSataPTSSPSSTFS 273
Q6NYU3        210 SVVTPS-GPSVD--------AVKPFR-SFN-YCSsy-eSFY--ESVSP--ECGSPQFEG-PLS---PPINFNGIFS 265 zebrafish
Q9W6C7        198 EMATPT---GLSSGtr---eSVKPFR-PYN-YYAsy-eSYY--DSASP--ESSSPHFDG-QMS---PPINYNGIFS 256 zebrafish
10_pfamImport  63 ELGTPTgHGSGTVD------SAKPFR-PYG-YCNty-eSFY--ESTSP--ECISPQFEG-PLS---PPINFNGIFS 121
8_pfamImport   64 HHHHHP-HHHHHPHhq---dSAKSFR-PYG-YCGay-eAFY--ESASP--ECASPPFES-ALSpppPPLSFSGIFS 127
XP_005462360  205 EAGGST-TAG----------SGRSLR-PFGsFCSpf-eSLN--DSSSP--ESSGSLDMG-TLS---PPFNFSGLFT 259
XP_022534450  196 AGRSSS-VGTMD--------SGKPLRsTYG-YCSt---SPYehGGGYElgGC-GPRLE--------PPLSYDGIFS 249
XP_002642781  126 ----PL-FPQ----------HPQHLQnPPH-HQSf--cPSS--ESPTSs-SCSPPQYYYsPNQpsaAPLQATCELA 180
EGT45690      126 TSSSST-QHPL---------HLHHSH-PQQ-HSSs---SSF----SSPtsSCSPPQYYYsPNQpsaAPLQASLDLA 182
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