Conserved Protein Domain Family
DUF3731
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pfam12531: DUF3731 
DNA-K related protein
This domain family is found in bacteria, and is approximately 250 amino acids in length. There are two conserved sequence motifs: RPG and WRR. The proteins in this family are frequently annotated as DNA-K related proteins however there is little accompanying literature to confirm this.
Links
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Statistics
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PSSM-Id: 492691
Aligned: 36 rows
Threshold Bit Score: 283.337
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_013564722  694 PRHEGRWCNLAGFALRPGTGFPLDEARVKALWPLFHQGPKHPKDQTVWNEWWVMWRRVAAGLNRRQQDEFHRKVAPLV-- 771  Isosphaera pa...
WP_011697216  711 AQHEARWLNLLGFCLRPGYGDPLDEWRAKEAWKLYPAGLSFARQPQNRSEWWIFWRRAAGGLSAGQQQRICQEVLPGL-- 788  Syntrophobact...
WP_013907166  667 AAHEARWFNLLGFFLRPGYGDISDPFRVGKIWGLYFEGVTHKRDKAVQLEWWIFWRRVAGGLSRGKQEQLFAKIKPYV-- 744  Thermodesulfa...
WP_012609911  679 ADYEARWLNLMGFCLRPGFGDALDEHRMRTLWSFYKKGPVHPKNPQVMLEWWVLWRRAAGGLTPGQQRQVFQDLMPQM-- 756  Desulfatibaci...
CCK81477      690 AQFEHRWLNLTGYAVRPGFGQSFDEERVKKIWKIFKQGPVFNKSAQVKSEWWILWRRVAAGLTAGQQRQFVQELSSLI-- 767 
WP_015904814  681 PEHEVRWLNLTGFCIRPGFGDAFDGERMRKLWKIYLAGPIFPKVKQNVSEWWIFCRRIAGGMNAGQQRQFFQDVTPLL-- 758  Desulforapulu...
WP_004075096  704 PEHEIRWLNLTGFCMRPGFGDAFDEARMPKLWKVYLQRNVFPKAKQNAVEWWIFCRRIAGGLTAGQQRQFFQDVSGYL-- 781  Desulfobacter...
WP_013108903  707 AAHEARWLNLVGFCLRPGYGVAIDDWRVAETWKAISGKLTH-ADPQVRAEVLVLWRRISGGLNAGIQQAIAAPYISMVkt 785  Planctopirus ...
jgi:Psta_1952 696 PAHEARWLNLLGYALRPGYGLAVDDWRVAETWKLVHGKLAH-GVPTSRTESLILWRRIAGGFTAGQQKAISQPMLTTL-- 772 
Q7URC3        739 PAHESRWLNLAGFALRPGYGVAVDDWRTSQTWRMIYGKISH-PDHQVRAESYVMWRRIAGGMTAGQQSQLATSLGRWL-- 815  Pirellula sp.

WP_013564722  772 LpakPGAAGARKLGrAKPEGQEAVELWRCLASLERLAPSQKETLGEVLIRDLAR--PKPGPASL-WALGRLGARNLVAGP 848  Isosphaera pa...
WP_011697216  789 QleeQRKKGTTRKGgAPRTVQEELETWMMLANLERLPAAVKTSLGRLMLRRLQR--GAPRPQEL-WTFARFGARVPFYGP 865  Syntrophobact...
WP_013907166  745 -------LPGQGKKvPKVSPQERREIWLCVANLERLSPEVKYELARKVLPQAL---KKNDRLFI-FVLSRLLARVLLYGP 813  Thermodesulfa...
WP_012609911  757 -------KNAKAGK-LKIPPQQKLEMWMLLANLERLHIKDKLECAKLLMEELHP--KKAKPQQW-WSLSRLGSRELLYGP 825  Desulfatibaci...
CCK81477      768 -------SHKKTSA-PKISPQERLEIWMAVANMERLLVKDKVKWGNQLLSEMIA--KKSVDQHF-WSLSRIGARELLYGS 836 
WP_015904814  759 -------LGGNGLK-KKVSPQELTEIWMAAANMERLLVKDKVSLGRAICALLNP--GKSPAQLF-WALSRIGARELLYGS 827  Desulforapulu...
WP_004075096  782 -------LANNGAG-KKVPKQEMTEVWMAAANMERLLIKDKIALSQKLIPQLKP--DKTPHQMF-WALSRLGARELLYGS 850  Desulfobacter...
WP_013108903  786 AlkrGLDHRKSANK-SGPTSHELSEMMRMFGAFEELSKTTRSELAGLAEVSLQQknSPITMDAAiWSLGRFGQRTPVYGS 864  Planctopirus ...
jgi:Psta_1952 773 KafhKRATSAGKSSePMLSPHESIELVRLVGSLELLDVPTKITLGQMFLELLGRpkLANIRAALaWSIGRLGSRVPVYGP 852 
Q7URC3        816 ----LAGTSNQDMA-------EANEAWRTIGSLERLPIDQKRSFATAVMESLDRkkASPLYPSLfWTLGRLASRVLAYGP 884  Pirellula sp.

WP_013564722  849 ANAVVPPTVAAHWLAPL---LNRE---PTDprdcaaLALTIAWLIQFTGDRARDLEPDLRDRGRAALERLGCAPELIDAV 922  Isosphaera pa...
WP_011697216  866 LDQTVPREEAALWLAAL---LDLDlepTQP------LARTLVSLSRLTGDRARDLDRADRDRVLRRLESIPGTSHLRALV 936  Syntrophobact...
WP_013907166  814 ADAVVPPKKVKPLIEEM---ISHLkkqKIPekiarlWAEALINIGRLSGDRALDLPEEIRLAIKELLVSWNIPAENYQPL 890  Thermodesulfa...
WP_012609911  826 LDRVVYSKDATAWINTI---LETEwknPKP------VCQALAHLARMTGDIKRDIEEADRAKVLEWMKNKGAAKSLTKMV 896  Desulfatibaci...
CCK81477      837 VDRVIPPSKVEPWIEKL---LSFKqqnPKP------VAAALVQLARKTGDRMRDINPETIDRIQEWMTNQNISDAMTKPL 907 
WP_015904814  828 VDRVVPPREAAVWIRKM---IKKQkrrDLP------LAKALAQIARKTGDRTRDLDSETIAPLVEWFD-LTKTQKCSAIV 897  Desulforapulu...
WP_004075096  851 VDRVVPAKEVERWTKKL---IKIRwnpKDQ------IAAALAQILRKTGDRTRDVSRDIIQIMVPWLEQMQAPKKSFDII 921  Desulfobacter...
WP_013108903  865 LDHVLSPERVESMLAAL---MTCGgpi-------glVGLSLAQIARRTHDRYRDLPQALREEVVQWLNQHPETEDLAKLV 934  Planctopirus ...
jgi:Psta_1952 853 LNTVLPASEVATWLEKL---LATApld-------vpLQLAIVQLARKTDDRFRDISGALRTTIAAQLTASGASDESLKLV 922 
Q7URC3        885 LNLILPATDVSHWLQKLshsPSLN---TSDeatkrlAAFTITQMTRRCDDRFRDVDQPTRDRALSLLDRLGAPDHWIELV 961  Pirellula sp.

WP_013564722  923 QRPpHdDIDRTRAAAVLGDSLPIGLRL 949  Isosphaera pallida
WP_011697216  937 NDArT-DLEGTEREWLYGESLPSGLIV 962  Syntrophobacter fumaroxidans
WP_013907166  891 EKV-V-ELEEAQRTRLFGETLPLGLKI 915  Thermodesulfatator indicus
WP_012609911  897 AQV-V-AMDRQEEDSMFGEALPAGIVL 921  Desulfatibacillum aliphaticivorans
CCK81477      908 HHV-V-CLSKKEENTIFGEALPSGIVL 932 
WP_015904814  898 REK-V-EIKAVETSAIFGESLPQGLVL 922  Desulforapulum autotrophicum
WP_004075096  922 HTV-V-PIESADEASIFGESLPQGLIL 946  Desulfobacter postgatei
WP_013108903  935 KEG-G-EFTQESAGQLLGDQLPPGLSL 959  Planctopirus limnophila
jgi:Psta_1952 923 EQG-G-DLDSLQQRHVFGESLPIGLRI 947 
Q7URC3        962 KNG-G-QLDHEEQQAVFGDTLPLGIEL 986  Pirellula sp.
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