Conserved Protein Domain Family
DUF3730
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pfam12530: DUF3730 (This model is not part of the current CDD release)
Focadhesin/RST1, DUF3730
This domain of unknown function is found in Focadhesin from animals and RST1 (RESURRECTION 1) from plants. Focadhesin (FOCAD) is a focal adhesion protein with potential tumour suppressor function in gliomas. RST1 was originally identified in a genetic screen for factors involved in the biosynthesis of epicuticular waxes. Later, RST1 and RST1 INTERACTING PROTEIN (RIPR) have been shown to act as cofactors of the cytoplasmic exosome and the Ski complex in plants. It is involved in the suppression of siRNA-mediated silencing of transgenes and certain endogenous transcripts. Structure predictions suggest that this is an alpha-helical domain with and armadillo-like fold.
Links
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Statistics
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PSSM-Id: 520316
Aligned: 27 rows
Threshold Bit Score: 135.1
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_046443298   442 LTLLLKKLTTPs----NGKTKLAILYHLPSLAIDK---------TCVPRVLQIYEALSSS-----PQLKPVRIRLLADLW 503 
4_pfamImport     1 LLELQSALEGT-----DEKFVSLFVKGLGFLIRVGfnrnhgswrFGSPENHPFVRILLCRtevqtELVQQVLLFMAKNMR 75  
XP_014754965    88 LPFLLAPLSASp----SPRLAACLVKAVAAVVSCVlrsg-pagsRFAPYNHPFVQALASGadgarAELSRQAARMVAE-- 160 
10_pfamImport    1 FQELLAGLEAC-----NARSLSLFVKGIGLLCRIAveke-pswlIGPPDLHPFVKVFGCRvevhnELIQQLILQILHMES 74  
XP_009151936    79 LLELQSALEGC-----GSKLVPLFVKGLGFLIRIGyeqklgnwkFNSTENHPFVRILSCRvetqtELIYQVSLFVMRNRR 153 
Q7XZF5          82 LLELQSALEGC-----DSKLVSLFVKGLGFLIRIGyernngnwkFNSTENHPFVRIQSSRvetqtELLHQVSLFVMHNRR 156  thale cress
6_pfamImport     1 LLELQSAIEGS-----NSRFVNVFVKAIGFLVHFGfqknislfrVESPESHPFVKVLSGGtevhsELVQQVLLFISQNKG 75  
1_pfamImport     1 LLELQSALEAS-----DSRFVSLFVKGIGFLVRLGfqnn--slpSLSSENHPFVKVLSCRvevqtELVQQVLIFIMQSKN 73  
5_pfamImport     1 LAVLFYSNIFTrndakNQEILPKLLSMLPSLASHF---------VMIPLVIQTILPMLQKdg--kRVLYATGARLLCQTW 69  
Q7XZF5         523 LAVLYFSNLLSrtnvpCQSLLSKLLGLLPSLAAQQ---------VMIPLVVQTITPMLRKda--kGLLYATAIRLLCQTW 591  thale cress

XP_046443298   504 KIEDRVYPFLEKVLN--------------ADQQQTEEFLIAKATA--------------IDIICMNRSDKYGAE------ 549 
4_pfamImport    76 LGMVKVCEFLKPLAVfsilsipfsnstssLFARQLIPSMASFCCSlpeeal---pvlklLMGCLKYLPHKNSDVgilvyr 152 
XP_014754965   161 -GVHGVVGFLRPFVMfavvr-----kgdaAFARDLIGALAAAAATpaansydavpvlklLGESLLHFGRGDGEEarlwl- 233 
10_pfamImport   75 LNSRDVVKFVRPFLMltvlqas-issassFFVRRLLSTLASLACSlssegl---pifktLIESLKYFPWESSEDfacli- 149 
XP_009151936   154 LGMVGVCEFLEPFLNfvilrvpfadsspsLFVRELISSMASLCCScrheal---pvfrlVLRCLKYISGKNSEDnrnfs- 229 
Q7XZF5         157 LGMVGVCEFLEPFLNftilriplsdssssLFARELISSMASLCCSsrheal---pifrlLMRCLKYIPGNNLEViv---- 229  thale cress
6_pfamImport    76 SRMVEVCDFLRPFSNfsvlriafsdssasSFVRHLISSTASLCCSfpream---pvfklLMGCLRYYPQKNAEDfkifi- 151 
1_pfamImport    74 SGMVEVCDFLLPFLNysivrmp-ssvsvsSFIRSLVSSLAGLCCSipleai---pviklLIGRLKFFPCDNAEDftnis- 148 
5_pfamImport    70 AINDRAFSSLQAVLLpe----------gfTEFKSERTICIGLATS--------------IRDVCRKNPDR-GVD------ 118 
Q7XZF5         592 VVNDRAFSSLQEVLRpq----------gfIEYISERHICISMAAS--------------IHDVCKRHPDR-GVD------ 640  thale cress

XP_046443298   550 ----------LLSVISDLLnsslGKLTACSATIATLSLRSLVSLCRA-----------E-VVDLKSVWDLLAPKLNQDH- 606 
4_pfamImport   153 ildcyyflecVVDAYTVVLrs-lVQTGLLVTKAQLFGVELSETILSLlthvhgrsggaEpIVELVKRLIVIQKDLSLCY- 230 
XP_014754965   234 -----ssvesLVDAYVILLrk-lAHAQRPSYDAQASSVELIETLLSQcslhhqlvgmaCgVLGLSKYLFVVQKDLGLCY- 306 
10_pfamImport  150 -----acaedLVDAFEAILkq-mAGSEELVNEAQALGTDLMDILLSYrypwk-ltigiEpIMELSKRVVLIQKSYTLSY- 221 
XP_009151936   230 -----civktLVDAYTVVArd-lVGSRLEVIEVHVLGVQLVDTVLLLcasphvqnteqEaVIESLRHLLAVQKDLGLPY- 302 
Q7XZF5         230 --------kiLVDAYTVVVrd-lVGTGLEVTEVHLLGVQLVDGVLFLcasphvqtteqEsVIESLKHLLAVQKDLGLAY- 299  thale cress
6_pfamImport   152 -----nimeyMVDAYTVVLkh-lVGVPSLSNEAQLCGLELLETVHSQhsdhhkhfggsEpIVELSKRLLVVQKELGLPY- 224 
1_pfamImport   149 -----hclecIVDAYVVVLqq-lVEMGSLLHQVQLCGVELLDVMFSLctnpk-htssiEnILEVSRRILIVQKDLGLSF- 220 
5_pfamImport   119 ----------IILSVSACI-------ESQDPIIRSFGLQSLAYLCEA-----------D-VIDFYTAWDVIAKYVLGYSs 169 
Q7XZF5         641 ----------LILSVQACI-------ESQNCPVRALGFQSLSHLCEA-----------D-VIDFYTAWDVIKKHAQHIKl 691  thale cress

XP_046443298   607 RASVVSEMCNLLGLTAELRIDNEEYDEFIHQAISTLFRVSLSTNVT------EVHSLALRSL 662 
4_pfamImport   231 IPELSSVILSSFAILIQSELEHEQLSLLKLVIFLVKWKGENECAFD------RATCALSEEV 286 
XP_014754965   307 LPEISAVLSSLSCILSGLEFEHEQLAGLKLLAFLIEWRLENALETN------EAVNHFSEGL 362 
10_pfamImport  222 LPDFSAIVASLFCILIATEIEHEQLSILKLSTLLVKWRHESEYVRG------RHGVCYGEEL 277 
XP_009151936   303 SRDLSLVVLSLLFMLAKSSVEHEQLSILKLLLFLLKWKSENENFSV------RDAACSSVEP 358 
Q7XZF5         300 SHDLSLVVLSLVFMLAKSTVEHEQLCILKFLLFLLKWKTESENLSV------KDAAGSSVES 355  thale cress
6_pfamImport   225 IPELLLLMSSLFVILIRSELEHEQLPVLKLVLFLLKWKNENEYMVG------RAQCDLSEEL 280 
1_pfamImport   221 IPELSTITLSLFMVLMQSELEHEQFLEVKLVLFLLKWKHENENDVF------RDAYDLNEEL 276 
5_pfamImport   170 DPVLAQSICMLLRWGA---MDAEAYPEASRNVLQILWHVGASKHGNdvvqwaKARAYAFQAL 228 
Q7XZF5         692 DPLLAYSVCHLLKWGA---MDAEAYPEDAENVLNILWEIGSSMQKPhdsqwtKARVSAIVAL 750  thale cress
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