Conserved Protein Domain Family
DUF3723

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pfam12520: DUF3723 
Protein of unknown function (DUF3723)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 374 and 1069 amino acids in length. There is a conserved LGF sequence motif.
Statistics
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PSSM-Id: 372162
View PSSM: pfam12520
Aligned: 28 rows
Threshold Bit Score: 501.01
Threshold Setting Gi: 242759941
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EJP69837      61 GETQNRIPAIISETELQDALAISNLTRgdlVARGDSF-----ARLDLPSAFQLKCLRGEDRVQAAREVLNSP-----EPR 130  Beauveria bass...
XP_001536438  63 LEPQHWIPAVVTRNGLQVILNANSLSS---IGGDDPGd----FPLSLPSGHEVTCLQGRIRHAAGTKWLETD-----DQW 130  Histoplasma ca...
EMD97598      60 LDPENFVDALISRECFDTALFRKGITLeafKESCSTVddcvqTPIKLDLNTSIQCLNGLQRIRAAEAFLDNN-----DKW 134  Bipolaris mayd...
XP_003838685  62 LHDENILNAVVREDDLATALSRSNLTAaalRRIISATd---aPALHLE---KVSCLTGLHRIRAADRFLDPN-----DKW 130  Leptosphaeria ...
XP_001942238  61 LEEENVINAVIADEDLVAELSSQGKSIedfCNLQWPQd---aLDLPLE---YVDCLSGMHRIEAARRFLDEN-----DKW 129  Pyrenophora tr...
EOA84436      62 LQDENVIDAVVEDARLDAALRAIGLSIealQKVRSPKd---aPTLHLR---ELKCLNGLHRIRAADQFLDEN-----DKW 130  Exserohilum tu...
EMD95298      62 LQDENVIDAVVENDRLDAALRAIGLSIealQNIRSPKd---aPTLNLR---ELKCLNGLHRIRAADQFLDEN-----DKW 130  Bipolaris mayd...
EEH06960      62 LQPENYIPAVVSHEDLANALQLSEISQgdlLQDGEP------HTLELPLGVSITVIHGKHRLLAAKQFAVDKfllesEQW 135  Histoplasma ca...
EED21208      57 LDPWNHVPVAIDRNTLSARLRLAGLDNddlIREGEP------PLLRFTT--PLRVLHGRRRLLAAEEYLW-------DKW 121  Talaromyces st...
EDN08139     116 EDPENYVPVLISQNTLSQAIDDSRTTQvvlLNGIEP------PNLILGHGTRLLCLQGKSRIRAAQEFFSPG-----ERW 184  Histoplasma ca...
EJP69837     131 WVVDLYAA-----------------DISDETRRDLAEEYACEQAPADGDFYFKIREYQgvfGQENSRAEDTWKARLgats 193  Beauveria bass...
XP_001536438 131 WILKLYDS-----------------RLSSEARRSLREDRDASQEFSSGEIYWNVRHHE---RQGNDDERRKWLARWp--- 187  Histoplasma ca...
EMD97598     135 WIVNLYEDa----------------TFERTLETHLYESYNHEQQYTDGIIFRNIRRYA---RVHDTENEKKWWARL---- 191  Bipolaris mayd...
XP_003838685 131 WTVRLFSN-----------------DTPQPVLCHIIESYANEQKPRDGDIFRKIRYYH---REKDAEAENRWWARL---- 186  Leptosphaeria ...
XP_001942238 130 WVVRLFSH-----------------NTPKPVLAQIIESFANEQKPSDGEVFRKIRLYH---RENDEEAQKRWWSRL---- 185  Pyrenophora tr...
EOA84436     131 WVVRLFSS-----------------ESPTPILFHMVDSYINEQKPSDGEIFRRIRLYR---LENKVEAERKWWARL---- 186  Exserohilum tu...
EMD95298     131 WVVRLFSR-----------------ETPTPILCHIVESYKNEQRPSDGEIFRRIRLYH---RENKVEAERKWWARL---- 186  Bipolaris mayd...
EEH06960     136 WVVKLYSD-----------------SLPAPARSAVREEYSHTLQFCDGDIYRSWRFYQ---TQGNVEEAARWLARL---- 191  Histoplasma ca...
EED21208     122 WIAELYSDgdyqttyiivlninlyeDLPAKLKTSICEQYSHSRPFCDGDIYRHIFKYQ---RDGNIDEEEKWIRRL---- 194  Talaromyces st...
EDN08139     185 WGARLYLD--------------------TAARDRLREKYSNEQNFGDGDIYRNLRYHQ---LRGNGPRAEAWWARW---- 237  Histoplasma ca...
EJP69837     194 gSGHKKNRMDQI---VTDPRLCVAFDAFRRIPVLYGDLKLS---------LVNKMTSMGCHEESLHYLNHIKDFWHSVFD 261  Beauveria bass...
XP_001536438 188 -SPYMERDFTQLresIYSRPLYEALDRLLEFRALWPAFHVG---------NLHRLLPMRCPEALASYLDFIRDVWMWITD 257  Histoplasma ca...
EMD97598     192 -TATKRKDLAQL---LSNQKLSLAFDALIDYAGLWTPIRLG---------TLHRFHALKCTKELKSYLRHIHTVWDSLIP 258  Bipolaris mayd...
XP_003838685 187 -DKSKPKDLRQL---LKRHKLASAFDALIDFPGLWAKIQLG---------ALHRLLTLKCDEEMIRYLNHVALTWTTILK 253  Leptosphaeria ...
XP_001942238 186 -EKSKPKDLRQL---LRRPTLIAGFDALIDMPGLW-------------------------AKEMALYLDYIAKAWSKILR 236  Pyrenophora tr...
EOA84436     187 -DNSKPKDLRQL---FKRREIISGFDRLLEMPGLWAKVQLG---------ALHRLLTLKCDEEMANYLSHISKVWTKILT 253  Exserohilum tu...
EMD95298     187 -DNSKPKDLRQL---FKRTEIISSFDKLLEMPGLWAK-------------------------EMAYYLNHVSKVWTKILT 237  Bipolaris mayd...
EEH06960     192 -SPRKRADVQQLq--IKHHALSRGFDQLLPFIGLWPKLEIVprydasfllLLNR--SSQPTQALLHYLDRMHSMWSVILG 266  Histoplasma ca...
EED21208     195 -SNSKTMNVRQLr--TKYRRLANGFDRLTPFVGIWYQLHLG---------CLSRLLPDKTPEEFLHYLERMRHQYSSIMG 262  Talaromyces st...
EDN08139     238 -SSPKRRHVRQM---QKQERLLNQFDRLLPYVGLWASVNVK---------LFRRIVDSRCYEESINYLDQTFKVWSVL-P 303  Histoplasma ca...
EJP69837     262 GNEsa--mMKLDRTSLEALQLTAPGACEKQARDLHARIRSGDILSAFTEAE-RERIWSKIYDAtvDCTVPSLHSFFEDRK 338  Beauveria bass...
XP_001536438 258 SRP-----WRLEETDVEHLEGRSPMWSKADGIYIDEVFKDGTVFCRIINQDeREVLRQRVRQC--STIIPSIRTFLEDSK 330  Histoplasma ca...
EMD97598     259 NEHrv----hVDSRTVSMLEMLAPSVSTRDAARARQLMLDGCIFPQLEDIHaRNEILNRIQSQ--KCMIPSLRTFFEDQK 332  Bipolaris mayd...
XP_003838685 254 YESttmspSIVDAVTVNHLELLAPNHSKIDRDLLLDLMDRQILFPSVIDNQqRRALASNLCAT--IGLIPSLWTFFEVLK 331  Leptosphaeria ...
XP_001942238 237 CGErtlpfSIVDAVTVQNLQLLAPAHSDMDKNLVIELMERRDIFSSLKSGTiRRTLTDNLCAF--PGVIPSLWGFFEMLK 314  Pyrenophora tr...
EOA84436     254 CRNvtlpfSAVDTITVESLESLAPKHSSIDKAYVLDLFKRNIIFPSQLDSGiRQELAENVCAS--EGLIPSLWTFFETLK 331  Exserohilum tu...
EMD95298     238 CRNitlpfSAVDTVTVDNLESLAPKNSSVDKAFVMDLFERNIVFPSLLDSQiRRELAENICAS--EGLIPSLWTFFETLK 315  Bipolaris mayd...
EEH06960     267 DQRys----lVDQGTVALLETMAPGDANADAALIQDRMSRREIFPAIDEQYeRDAILQNILGI--NGRILSFNTFFQDLI 340  Histoplasma ca...
EED21208     263 TEEpf----lLDPKTVYLLETMFPALSVSDADHIKRLMNDGVLFPAVQSQHrRKKLLDNILGV--KGRILSFYTFFQDTI 336  Talaromyces st...
EDN08139     304 HDAaa----lVDAQSVHLLEGLMPAYSLVDQKRIQDLMNNREIFPALIDSErRSKVLERLLQV--SGRILSLHTFSQDLL 377  Histoplasma ca...
EJP69837     339 YIEDAAHCMKRLFPGKLHETIRSALESAYPDvdDQGTECLVQVSNSSYAMVAt---NGADHFDLAYRQLWLYARRH-FED 414  Beauveria bass...
XP_001536438 331 YLEPMAKLVRMLLPPDFKGTVQEGMRRCYQP--SANGVLHIQTSAAGHRTAPr--dADDDGFWSAYRQVWLGAMRDwFGI 406  Histoplasma ca...
EMD97598     333 YLEPCSKILKQLLGVKSKRPIWKEFKANYWE---HESEIKVQISETKNLPLPgs-lGKKERAKLGYLQLWMFCFRH-WPE 407  Bipolaris mayd...
XP_003838685 332 YLEPMCEILKDLIGGKQKRTIHSSLMANYYP----PATPMVQISDTTEAEITip-lSKAEAAKVSYIELWAFCGRH-FDG 405  Leptosphaeria ...
XP_001942238 315 YLEPLAEALRHLLGKDMKRTIRSSLMGLYFA----PSKIMVQTTETQDVEIKva-lSRKQAGMIAYTELWAFCGRY-FDG 388  Pyrenophora tr...
EOA84436     332 YIEPICEILKKLVGSNMRRTIRSSLMGHYFP----PERRHIQVSKLREAEITsl-lSREEAAWISYVELWAFCGRY-FAK 405  Exserohilum tu...
EMD95298     316 YIEPICEVLKKLIGGNMKRTIRSSLMGCYFP----PEKRYIQVAKFREAEITsl-lSQEEAAWISYVELWAFCGRY-FNK 389  Bipolaris mayd...
EEH06960     341 YLEACVNSLCFLLPSTFPGSLRDTFTGVNQV----AGEIRVQTRDHGMVVWPnergEWDQCRELGYQQLILAAMRD-FPS 415  Histoplasma ca...
EED21208     337 YFGACSKILRNLLPPKFQGTVRQAFFNSYQQg-INQGRIRLQSYGERMLDRPg---TEVTHVQLAYRQLYLAAMRD-FPI 411  Talaromyces st...
EDN08139     378 FLELPSKALRGLLPKTFKGSVRNALLKKYVH---TENSYIIQTSAAGYRIAAg---TLKAASYLSYVPLWLCAIRL-F-- 448  Histoplasma ca...
EJP69837     415 MPPEREHI-----------------VAGYKTAGVDEMVLFDFASLAYKLGFRTTEIKKLLQGn--pDRQI-AHRLLKMAR 474  Beauveria bass...
XP_001536438 407 VPGFRPRKmt--------------kVPGTVAQPHPSILWSRFVDLAVSVGFNISKRPDFSES----PEDI-IRQCLSLLR 467  Histoplasma ca...
EMD97598     408 MTSFTPRLesglkitdeadmrnievRPKSARRDHNPALWQRLACLAMQVGFETSNICKLAGEd---aEMVqAKQFLNSAR 484  Bipolaris mayd...
XP_003838685 406 LTAFTPRKei--------------nGTKPLVKGPNSVLWHHLAKFAVSRGFKTKRAQELAATd--pYTQL-AREYLYKAN 468  Leptosphaeria ...
XP_001942238 389 LTAFTPRKet--------------gEPKPTVNGPNPVVWQHLARFAVSRGFQIPHAQALVADegrlRSQL-ALEYLHKAR 453  Pyrenophora tr...
EOA84436     406 LTSFTPKKes--------------gEVKPVVEGPNPVLWRHLANFSVSRGFKTKPAEKLANSd--pYTEL-AHEYLRKSS 468  Exserohilum tu...
EMD95298     390 LSSFTPKKes--------------gEEKPIVEGPNPVLWQHLADFSISRGFKTKSAQKLANSd--pYTEL-AQEYLRKSS 452  Bipolaris mayd...
EEH06960     416 LSQIAPRRdq--------------gKPASVVDSPSEECRQGIANLAFNLGFETSEIRNLRAVd--pTRDL-ASKFLSRAR 478  Histoplasma ca...
EED21208     412 LSSLAPLWds--------------kKRRPLIQGSPSERWHQIASLAFVLGFRTDEIAKLMEDg--nNKEImAREFLTKIR 475  Talaromyces st...
EDN08139     449 ---VSPLKds--------------hTSEAIHTFSSIRGLPFLADEAISLGFSSTEIKKLSNQd--aNEQT-CRYFVEHMC 508  Histoplasma ca...
EJP69837     475 KPDQFYFED--IESSISAVTTVMEAARPICNSQDv-DVEEPEVVAAGATAKQCGRPLVSDHMRCKPLLFLDKLH-ATMAR 550  Beauveria bass...
XP_001536438 468 PADLFEQDPdlLSAESRRVAENLGFRRRPAEIARpaRPSLTTDLGAWSITARCGMTDGASFFSDQKYLFLDNIYaRLDDV 547  Histoplasma ca...
EMD97598     485 PE-----WEsnRSDCERKIADILKSMQGTSSQKPqtPIWVDDGVMSWPREKRCGKPHEADHEHDKSVMFATMFY--HPLQ 557  Bipolaris mayd...
XP_003838685 469 P-----ICAspKDSQVRRVVHASYPEVNIRGPET------LPEALHITKERRSGRTFESDLEYDKKLLFLPHVY---GSD 534  Leptosphaeria ...
XP_001942238 454 P-----TCPtfSDNDVRKVLDAVPVDMDISQHQS------PLPLPHLSIDRRIGRPFAGDFAEEKRLLFFPHLY---GPV 519  Pyrenophora tr...
EOA84436     469 P-----LSSlsCERQIQEVLRASRIVDDDSQQPQ------SVLSGHLEKERRSGRPYENVLRMDERNLYLPNIY---NSE 534  Exserohilum tu...
EMD95298     453 P-----LSSssHERQVQEVVRASRIVEDDSQQPQ------LVASGHLEKERRNGRPYENDLRMDEQNLYLPNIY---NSR 518  Bipolaris mayd...
EEH06960     479 PPEFYDLDEnlVNDIVSYIAEHLPRAARLRPLNR--PPEFTTNLLSQPKDDRCNRPRHAAYKNDREYLYLDVIY-NYQPT 555  Histoplasma ca...
EED21208     476 PAELYIVDEgrKERLVQYIARQIDGIATPRVLRQ--DAEFTTNVEGLAKEQRCNRPYDSAYRRDKDFLFINIIY-GTRIR 552  Talaromyces st...
EDN08139     509 QVELYEPEPkrLSDAVRRIQNTLKQLQEKRKIADg-VPVFSKNATSEPLCRRYNRPLASHLESDRCYFFIEHIY-GTDQS 586  Histoplasma ca...
EJP69837     551 QNRNLSSFFIQRSTYFAFFG 570  Beauveria bassiana ARSEF 2860
XP_001536438 548 PGVHLTSFAVKRDFFLAHFP 567  Histoplasma capsulatum NAm1
EMD97598     558 SSQTITSALVKRNVLEAFFd 577  Bipolaris maydis C5
XP_003838685 535 NPEEASLRLSRRYLFSTLFG 554  Leptosphaeria maculans JN3
XP_001942238 520 VFENASISLMRRDLFSCIFG 539  Pyrenophora tritici-repentis Pt-1C-BFP
EOA84436     535 EPVEANWTLIRRDMFHSLFG 554  Exserohilum turcica Et28A
EMD95298     519 EPTEAGWTLIRRDVFKSLFG 538  Bipolaris maydis C5
EEH06960     556 GGSHLTSLAIQRDIFVSFFS 575  Histoplasma capsulatum G186AR
EED21208     553 AQAFITSLAIQRDIFICFLG 572  Talaromyces stipitatus ATCC 10500
EDN08139     587 IAHHPTSIAVTREIIFSFFG 606  Histoplasma capsulatum NAm1
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