Conserved Protein Domain Family
BNIP2

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pfam12496: BNIP2 
Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
This domain family is found in eukaryotes, and is typically between 119 and 133 amino acids in length. There is a conserved HGGY sequence motif. This family is Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2. It interacts with pro- and anti- apoptotic molecules in the cell.
Statistics
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PSSM-Id: 403629
View PSSM: pfam12496
Aligned: 33 rows
Threshold Bit Score: 90.1395
Threshold Setting Gi: 1494785765
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002068910 127 PSARIIKPqd------------------------------------aKVSLLRGQSPdllssesDADVSqylaavesnfq 170 Drosophila will...
6_pfamImport   1 KKKVLVAP---------------------------------------ALSLSLGRSEst---vsGDFPStfls------- 31 
XP_011478998 151 KKKVLVAP---------------------------------------TLSLSLGGSLa-----sEDFAPgfls------- 179 Japanese medaka
8_pfamImport   1 RRKVLVAP---------------------------------------ALSLSLGGSEs-----mDDFPAafls------- 29 
7_pfamImport   1 -KKRLAAP---------------------------------------TLSVTLSPGGrdpqadaDGFVAlsa-------- 32 
XP_005462432  70 AKKRLVAP---------------------------------------SLSLTLNRRDsn---drNSFSAaals------- 100 Nile tilapia
NP_001121866  79 RKKRLVAP---------------------------------------TLSLTLDKTStdrslksDEFEAsals------- 112 zebrafish
XP_015192196  79 GKRRLVAP---------------------------------------ALSLTLDRANst---vsDEFATatls------- 109 spotted gar
EDS43205     141 PPLRLANPypnrtttttttrtttssttrtttstldvinnidnannvkKTGLLRDASPdflssgsEQDLSqfqasvtptfq 220 southern house ...
XP_003457277 156 KKKVLVAP---------------------------------------TLSLSLGRSGsm---vsDDLPSvfls------- 186 Nile tilapia
XP_002068910 171 svsllpnnana------------ngkslqqqkrnskrgptlpgqgEDISSL-DSIsNHSFDDDediehnlaslspsssli 237 Drosophila will...
6_pfamImport  32 ------------------------------------------ppaEDGDD--MWL-DLNLDGM----------------- 49 
XP_011478998 180 ------------------------------------------pspEDDDD--PRL-DLDLDAM----------------- 197 Japanese medaka
8_pfamImport  30 ------------------------------------------pspEDEDE--GDL-DIDLDAM----------------- 47 
7_pfamImport  33 -------------------------------------------spDETPSL-----DINLEAL----------------- 47 
XP_005462432 101 ------------------------------------------gtpDDTPSL-----DINLEAL----------------- 116 Nile tilapia
NP_001121866 113 ------------------------------------------pspDDDLDM-----DINLEAL----------------- 128 zebrafish
XP_015192196 110 ------------------------------------------pspDEDF-------DINLEDL----------------- 123 spotted gar
EDS43205     221 svalvqsqsgsqlqqqqeqqsfehksisprlherrnvplstdllvDDISSLeETVsNHSVDDLqqnlvslsps---ssil 297 southern house ...
XP_003457277 187 ------------------------------------------pspEDEDD--PAL-DFDLDAI----------------- 204 Nile tilapia
XP_002068910 238 dgldgEDDDDDDNCEGPELLPDNDDDLdmefglmattptpaaaaaASSTTAPGSSLPQYT-------------------- 297 Drosophila will...
6_pfamImport  50 -----ETPSDSGSLPFP--IYDPQGERs------------------KALADDHLLTETTS-------------------- 84 
XP_011478998 198 -----ETPSDSESLHFP--NYDLDLEDdlrrlgva---shkpfgsASGSLPDQTGLSALD-------------------- 247 Japanese medaka
8_pfamImport  48 -----ETPSDSESLLFP----ALELEDhlqh-----------lgvGASPGSREPGLGALG-------------------- 87 
7_pfamImport  48 -----ETPSGSESGTLA----ELEWEDdlpq----------mvrgGATPSSRAEQCEGLM-------------------- 88 
XP_005462432 117 -----ETPSDSETGTLPDSMHDLEWDDdlpqm--------grggaVGVARSPVEQSEGLM-------------------- 163 Nile tilapia
NP_001121866 129 -----ETPSDSESYNFPESMHDLEWEDdlprm---------gkasIRKPSLLEHAEMGHL-------------------- 174 zebrafish
XP_015192196 124 -----ETPSDSESWTFPESTHDLEWEDdlpragrregaaasgaaaAASTPVMEQAEEGQL-------------------- 178 spotted gar
EDS43205     298 ddngfNVDIDEDFLDVPGTPK------------------------NGAGSGSAPQLPQYS-------------------- 333 southern house ...
XP_003457277 205 -----ETPSDSESLPFP--MYDLDLEDdlrr----------------lgvASSHHRGHSSrsdpqtgclmetdqsglgfl 261 Nile tilapia
XP_002068910 298 -AAEERRDS-RNWQKITLPdG--RTREIDMRVIEPYKRVLSHGGYLKAG 342 Drosophila willistoni
6_pfamImport  85 -REDEVDEGgTRWRCFSVG-DppQESRVNMSVLEPFLRVLSHGGYYGDG 131
XP_011478998 248 -KEDVVDSKgTRWRCFSTG-DppQESRVNMTVLEPFLRVLSHGGYHGDG 294 Japanese medaka
8_pfamImport  88 -QEDVVDKEgSRWRCFCPG-EppQEAWVNMSVLEPFLRVLSHGGYHGDG 134
7_pfamImport  89 -ELDQVDASgRRWRRFCTC-G--QEYRVNMSVLEPYLQVLSHGGYCGD- 132
XP_005462432 164 -ELDQVDSRgRRWRRFCIS-G--HEYHVNMSVLEPYLQVLSHGGYFGDG 208 Nile tilapia
NP_001121866 175 -ELDQVDDYgRRWRHFHIG-G--QDYQVNMSVLEPYLQVLSHGGYYGDG 219 zebrafish
XP_015192196 179 -DLDEVDSRgRKWRVFRTA-G--QEHRVDMSVLEPYLRVLSHGGYYSEG 223 spotted gar
EDS43205     334 -ARDEARDI-RNWQKITLPdG--KTREIDMKVIEPYKRVLSHGGYLQAG 378 southern house mosquito
XP_003457277 262 eREDVVDSHgTRWRCFTTG-DppQESRVNMSVLEPFLRVLSHGGYYGDG 309 Nile tilapia
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