Conserved Protein Domain Family
BCAS3
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pfam12490: BCAS3 (This model is not part of the current CDD release)
BCAS3 microtubule associated cell migration factor, C-terminal
BCAS3 microtubule associated cell migration factor (BCSA3, also known as Rudhira in mice) has been shown to be involved in angiogenesis and metastasis, and to be implicated in the development of breast cancer. BCAS3 plays also a role in regulation of autophagy; it forms a complex with PHAF1 (C16orf70) which associates with the preautophagosomal structure during both non-selective and selective autophagy. This entry represents the C-terminal domain which seems to be important for PHAF1 interactions. This domain is also found in ATG18-like proteins from plants.
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Statistics
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PSSM-Id: 520297
Aligned: 23 rows
Threshold Bit Score: 119.745
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ERN07493      614 LSPNRDEELKVLAEPVQWWDVCRRTSWPEREE-NISgithSLPSVNGMPIDNVSYSNDetsSCGLPRNGvia-----ndS 687 
2_pfamImport    1 FRQIQDEELRVRVEPIQWWDVCRRSEWPEREE-CVS----ERQKYAKIIVDKSDSEDSyrtDLLEIKSD----------S 65  
XP_015578219  450 FVHIQEDDMKVKVEPVQWWDVCRRSDWSEREE-SVIgs-tNGQDAVEIITRKPSGENNfemVFLDTNGDvnekkssisyS 527 
Q8GUL1        610 HVQVQEDDLRVKVEPIQWWDVCRRSDWLETEE-RLPksitEKQYDLETVSNHLTSHEDa-cLSLDMNSHfsedkylkscS 687  thale cress
XP_014627424  600 VLHMQEDEFRVKVEPIQWWDVCRRSEWPERGDsCCSt--fDRQGGIEGVQEKISYSDFhglDFVGSRDEagekm-vkssS 676 
XP_004230156  614 VVQMQEEDTGVKVDPIQWWDVCRRADWPEREE-CIHgitlGGREPTDIVMEDSLSEDD----------Dkge-----kdL 677 
XP_002512315  615 SAQIQDEELRVNVESVQWWDVCRRADWPEREE-CISgitlGRQETTDMPMETSDCEDN----------Dtgh-----veS 678 
XP_024439437  618 SVQMQDEELRVNVESVQWWDVCRRADWPEREE-CISgitrRGQETKETVMYMSDGEDD----------Gigh-----sqL 681 
XP_003568475  611 QSQLQDDELHVTAEPVQWWDVCRRTNWPERDQ-DIAnvtfDNQRNSMMAVDTSDCEDSehsDVTPSNDGisr-----keD 684 
Q0DI99        609 sLQIQDDELHVTAEPTQWWDVCRRTNWPERDE-NIAnivfHNQRNSMMAMDASDCDSEh-sDSVPS-DGisg-----keM 680  Japanese rice

ERN07493      688 VKCDEKFHVYISNAEVQINSGRIPIWQKSKIRFYLMMPTSadekfgMNGNYGGEIEIEKIPICEVEIRRKDLLPVFD 764 
2_pfamImport   66 VKPLERSHWYLSNAEVQISSGRIPIWHKSKICFYMMDPPR------VKNHVGGEFEIEKLPVHEVEIRRKDLLPVFD 136 
XP_015578219  528 MKPHEKSHWYLSNAEVQISSVRLPIWQKSKICFYVMDSPR-------VNYNDGEFEIEKVPIQEVELKRKELLPVFD 597 
Q8GUL1        688 EKPPERSHCYLSNFEVKVTSGMLPVWQNSKISFHVMDSPR------DSSSTGGEFEIEKVPAHELEIKQKKLLPVFD 758  thale cress
XP_014627424  677 ENMQDRFHWYLSNAEVQGNFGRLPIWQKSKICFYSMSCAG------ASFSGTGEFEIEKVPANEVEIRRKELLPVFD 747 
XP_004230156  678 AKLCDRSHWYLSNAEVQLKSGRIPIWQKSKIYFCTMSLSGyeeqdiSRSSAAGEIEIEKIPVNEVEVRRKDLLPVFD 754 
XP_002512315  679 LKFHEQSHLYLSNAEVQMSSWRISLWQKSKMSFYVINDLEti---dIGDHTGGEFEVENAPVQEVEVRRKDLLPVFD 752 
XP_024439437  682 VKSHEPSHLYLSNAEVQMSSWRIPLWQKSKMYFYAMSHLGpneeniIEDQTGQEIELEKVPVHEVEIRRRDLLPVFD 758 
XP_003568475  685 MRVRERSSWYLSNAEVQISSSRIPIWEKSKICFYVIDHPAtel-vkTGSVNGGEIEIEKSSLHEVELKRRELLPAFK 760 
Q0DI99        681 MRSRERSSWYLSNAEVQISSWRIPIWQKSKIFFYVIDQPPaks-geSLSSSGGEIEIEKLPLHEVELRRRELLPVFK 756  Japanese rice
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