Conserved Protein Domain Family
ARA70

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pfam12489: ARA70 
Nuclear coactivator
This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.
Statistics
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PSSM-Id: 403625
View PSSM: pfam12489
Aligned: 32 rows
Threshold Bit Score: 75.1169
Threshold Setting Gi: 1316081055
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007247448 201 VPLAQWLF----GSRPVAS-APVGYQSSKNPQDWLLAPKEKPQv--YRPLVQFDFQKAWGQLKDLEVWLLKEKSP-LRER 272 Mexican tetra
XP_015203339 196 TELDNWILksssGSSPQSG-CQL----SFNLDDWLYKPKEKSQv--SCPFAQFEFDKMCTK-TDVEAWVLKDR---VPPR 264 spotted gar
XP_002940491 236 TPLSDWLQq--kNSSNISQ-CYTPYIPSLCTQDWLLKNHAEEPn-eELSKLKPNMEKIWGQLGELNNWLLQSQQK----- 306 tropical clawed...
XP_001638385   9 YVLEDVRAkislLEKAIDEvGSV-------------KKSLKISaadVKAQIRDNISRHLEALRNRETWLLSQVEVlQHGK 75  starlet sea ane...
XP_003230765  15 EPLDKCLRakkdLETAIAGiVKA-------------EQQVKDNwreVKAQIHSCISRHLECLRSREVWLLEQVDLiQQLK 81  green anole
Q1RMQ8        15 EPLLRCCDarrdLELAIGGvLRA-------------EQQIKDNlreVKAQIHSCISRHLECLRSREVWLYEQVDLiYQLK 81  cattle
XP_023183213   9 ssMKLCQEaqdqLEDAIGSvLKA-------------EQQLRDNtreVRSELQSCMSRQQEALRCREVWLLGQIELlESLK 75  southern platyfish
Q6P0F7        10 aaLRQCIQaraqLDEAIADiIKA-------------EVQLKSNsreVKSQLHSCISRHLEILRSREVWLLEQIDLvEQLK 76  zebrafish
CAG05121      22 gtLMMCQQaqdqLQNAINTvVRA-------------EQQLRENtreVRLQLQSCVSRQQEALRCREVCLLGQIELiEQLK 88  spotted green p...
XP_031458335  15 ETLAKCLQarkdLETAISGiVKA-------------EQQIKENwreVKAKIHSHISRQLECLRSREVWLFEQVDLiQQLK 81  Ring-necked phe...
XP_007247448 273 -----ANSSASS---SSSAFSIEKIDESDFLDMEEEDgvQtenneeiadteVLSDWLITPNTSNTMTNPLs---DADRW 340 Mexican tetra
XP_015203339 265 e----RSVSETS---SSTMMSIEKIEDADLNLSEGEE--Gqe-------teDLKDWLVTSPTEEKEELAEnkshADDKP 327 spotted gar
XP_002940491 307 -----EDLKHNN---SSSSFSIEKLEDGDLDSQDLED--M-----------DLSDWLISPTVTEDPTD------VAEKW 358 tropical clawed ...
XP_001638385  76 edvlrLQHAELNqavGTLKHALALLHKSDGKSEHIEE--Qlmh-----tiqAMEKFSLQPEESGFISFRA----LNMEL 143 starlet sea anemone
XP_003230765  82 eealqQQAQQLFwllGQFNCLIHQLEQPHS--NDLAN--Qisv-----cleRLGNLALNPEETSILNFEA----DVPFL 147 green anole
Q1RMQ8        82 eetlqQQVQQLYwllGQFNCLIHQLECTQN--KDLAN--Qvsa-----cleRLGSLTLKPEDSTALLFEA----DITAL 147 cattle
XP_023183213  76 tetlqHQLHQLHrlrGQFEVIAHQLQNSNNN-NDLSN--Qlts-----cmeKLASLSLAPEETPEMRFHA----DSRSL 142 southern platyfish
Q6P0F7        77 getlhQQLQQLHslkGQFDLLIHQLEYSGS--NSLTT--Qltn-----cleKLSSLNLTPEETPEMSFQA----DAHTL 142 zebrafish
CAG05121      89 tetlqQQLHQLHwlrGQFDVIAHQLQNNNNNSNDLSN--Qltc-----cleKLSSLNMTPEETPDLHFLA----DSRSL 156 spotted green pu...
XP_031458335  82 eealqQQAQQLYwylGQFNCLIHQLEHSYN--NELAN--Qisv-----cleRLESLTLKPEESSVLNFEA----DTSYL 147 Ring-necked phea...
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