Conserved Protein Domain Family
ARA70

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pfam12489: ARA70 (This model is not part of the current CDD release)
Nuclear coactivator
This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.
Statistics
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PSSM-Id: 520296
Aligned: 30 rows
Threshold Bit Score: 77.0722
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ELK08354      232 VPLSEWLL----GNKPACG-CEA-PYTPSTNLQDWLTQKQTLENn-qASDRAFNFFSNVWGNLNGLENWLHKSQQQeVPE 304
EDO46322        9 YVLEDVRAkislLEKAIDEvGSV--------------KKSLKISaadVKAQIRDNISRHLEALRNRETWLLSQVEVlQHG 74 
XP_008112664   15 EPLDKCLRakkdLETAIAGiVKA--------------EQQVKDNwreVKAQIHSCISRHLECLRSREVWLLEQVDLiQQL 80 
Q1RMQ8         15 EPLLRCCDarrdLELAIGGvLRA--------------EQQIKDNlreVKAQIHSCISRHLECLRSREVWLYEQVDLiYQL 80  cattle
13_pfamImport   1 SSMKLCQEaqdqLEDAIGSvLKA--------------EQQLRDNtreVRSELQSCMSRQQEALRCREVWLLGQIELlESL 66 
Q6P0F7         10 AALRQCIQaraqLDEAIADiIKA--------------EVQLKSNsreVKSQLHSCISRHLEILRSREVWLLEQIDLvEQL 75  zebrafish
XP_015203339  196 TELDNWILksssGSSPQSG-CQL-----SFNLDDWLYKPKEKSQl--SCPFAQFEFDKMCTK-TDVEAWVLKDR---VPP 263
12_pfamImport   1 SSLSNWLL----ESRPANRcAPI-GYQSSTDPQDWLLPQKESKQt-sCPEMASMDFMKAWGQLRDLEAWLIQDHSP-NRE 73 
11_pfamImport   1 GTLKQWLL----GSQVSSH--PDtGFQSSSKTEDWLLSPKENQT---SCPLVTYDFLKTWGQLRDLETWLQKDHTPvPRV 71 
XP_011601495   12 GTLKVCQQaqdqLQNAINTvVKA--------------EQQLRENtreVRLQLQSCVSRQQEALRCREVWLLGQIELiEQL 77  torafugu
ELK08354      305 Kps--yQKCNSSS---TTSPYSIDIENVGDLEFLDQDEM------DLSDWLVTPQESHNLEKPGngsceTTEKF 367
EDO46322       75 KedvlrLQHAELNqavGTLKHALALLHKSDGKSEHIEEQlmhtiqAMEKFSLQPEESGFISFRA-----LNMEL 143
XP_008112664   81 KeealqQQAQQLFwllGQFNCLIHQLEQPHS--NDLANQisvcleRLGNLALNPEETSILNFEA-----DVPFL 147
Q1RMQ8         81 KeetlqQQVQQLYwllGQFNCLIHQLECTQN--KDLANQvsacleRLGSLTLKPEDSTALLFEA-----DITAL 147 cattle
13_pfamImport  67 KtetlqHQLHQLHrlrGQFEVIAHQLQNSNNN-NDLSNQltscmeKLASLSLAPEETPEMRFHA-----DSRSL 134
Q6P0F7         76 KgetlhQQLQQLHslkGQFDLLIHQLEYSGS--NSLTTQltncleKLSSLNLTPEETPEMSFQA-----DAHTL 142 zebrafish
XP_015203339  264 Re----RSVSETS---SSTMMSIEKIEDADLNLSEGEEGqe--teDLKDWLVTSPTEEKEELAEnk-shADDKP 327
12_pfamImport  74 R--------SVSS---CSSSFSIEKIDEMEL--AAEEEE------ELNDWLVTPPTAAMETMS------DAERW 122
11_pfamImport  72 R--------TSSS---CSSSFSIENIDESELATAHVEED-------LDDWLVTPPTAAMETMS------DGERW 121
XP_011601495   78 KtetlqQQLHQLHwlrGQFDVIAHQLQ--NNNSNDLSNQltccleKLSSLNMTPEETPDLHFLA-----DSRSL 144 torafugu
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