Conserved Protein Domain Family
SPIDER
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pfam12485: SPIDER (This model is not part of the current CDD release)
SLy Proteins Associated Disordered Region
This entry represents the SLy proteins associated disordered region (SPIDER), which is conserved in the SLy protein family. It has a disordered nature and ranges from 143 to 154 residues long. The region includes a conserved LGKK motif of unknown function as well as a nuclear localisation sequence. In members of this group, found in vertebrates, this region is followed by a conserved SH3 (pfam07653) and SAM (pfam07647) domain, suggesting a role in the signalling function of these proteins. SPIDER is a part of the SASH1 protein that plays essential roles in tumour cell adhesion and migration. Multiple disease variants in the SPIDER of SASH1 suggest that it may play a role in the regulation of skin pigmentation.
Links
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Statistics
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PSSM-Id: 520295
Aligned: 23 rows
Threshold Bit Score: 109.803
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001373751  21 SLQRSSSFKDFAKSKPSsPVVSEKEFNLEDniPEDDTGGPITEDAGK---SAKKLGKKWRAvISRTMNRKMGKTMVKALS 97 
XP_031815024  17 RPKRSSSFGNFDRFRNN-SISKPEHSNDKC--EEEGINEGGEEESAKtpnNGKSLGKKMRA-ISWTMKKKISKKYIKALS 92 
5_pfamImport   1 -PKRSSSFGNFDRFRNN-FTSKPDDSTEVY--DGEPIHENGEQNK--------SLGKKMRA-ISWTMKKKMGKKYIKALS 67 
P57725        17 KPKRSSSFGNFDRFRNN-SVSKSDDSIEVH--DRELTN--GSEEQSKtssSGGSLGKKVRA-ISWTMKKKVGKKYIKALS 90  house mouse
XP_008113895  17 KPKRASSFGNFDHHRHH-SASKPDDSSEPC--EVDTVSDGGELGHSKtphNGGSIGKKMRA-ISMTMKKKMGKKYIKALS 92 
XP_014354176  20 KPKRTSSFGSFDRFRHHnSPTKPEEQVQLNpdEADNTADPEEQSQSKastNSGSLGKKMRA-ISLTMRKKMGKRYIKALS 98 
XP_015197224 331 DAQRSSSFGRFDAFRHQsSPVKPEENAETE----PTEGEAAAESCDQnqnKTGSLGKKMRA-ISMTMRKKMGKKYVKALS 405
9_pfamImport   1 KPKRSTSFGKFDGFRHNpSPAKPEENGTPA---------AEGESGTEhndKHSGLGKKMKA-ISLTMRIKMGKKHCKSFT 70 
XP_020564134  17 KPKRSTSFGRFEGLRHHsSHAKPEDNGTTV---------LREDCESPdphRSTGLGKKMKE-ISLTMRRKMGKKHVKSLS 86 
4_pfamImport   1 KPKRSTSFGRFEGLRNHpTQAKPEENGTTA---------PTDESETSdqnKSAGLGKKMKA-ISLTMRRKMGKKHAKSFC 70 

XP_001373751  98 EGmgDPLEEGSASPTSPD-CPLEGLASEVMPLAFTEQEDGGHlalSRQTSTSs-ELGSPGPGtvGCGQTSLRVEELmaPM 175
XP_031815024  93 ED--KDEEDEEDTYSYRNsDPGVAAYTEKFPLKGSDSMDSIY---SGQSSSS--GITSCSDG--TSNRDSLRLDDE--VP 161
5_pfamImport  68 ED--KDEEDGEDTHSCRNsDPIIGTHTEKVSLKASDSMDSLY---SGQSSSS--GVTSCSDG--TSNRDSFRLDDE--AP 136
P57725        91 EE--KEEESGEEALPYRNsDPMIGTHTEKISLKASDSMDSLY---SGQSSSS--GITSCSDG--TSNRDSFRLDDD--SP 159 house mouse
XP_008113895  93 ED--MDEEGKEYSCSNRDnDPGGGLHTEKVSLKTSDSMDSLYslnSGQSSSS--GVTSCSDG--TSNRDSLRLDDE--VP 164
XP_014354176  99 EE--MNEDTDGDS-PYRDsDTPDGPQSEKISLKASDSMESLYslnSGRSSSS--GITSGSDG--ISNRDSLRFDEE--VP 169
XP_015197224 406 EE------MGDGADREHEgNAETSHPMEKGPGTTNGSAESLYslkSGQSSSS--GVTSGSDG--SSNRDSLRLEEE--IP 473
9_pfamImport  71 ED------TGDDTDREAEaKAETSNPATKASHRTSNSLESLQ---SGQSSSS--GVTSSSDV--SSNRDSLRLEEE--VP 135
XP_020564134  87 EE------TGDDTDKGPEaEQEAGRAAEKNSAKTSISLESLY---SGQSSSS--GVTSESNG--SGQRDSLKLEED--GS 151
4_pfamImport  71 EE------TGDDTDKEPEaETESGPAAEKTE-KTSNSLESLY---SGQSSSSsgGVTSESNG--SGQRDSLRLEED--GS 136

XP_001373751 176 YTGPF 180
XP_031815024 162 YTGPF 166
5_pfamImport 137 YTGPF 141
P57725       160 YSGPF 164 house mouse
XP_008113895 165 YTGPF 169
XP_014354176 170 YTGPF 174
XP_015197224 474 YTGPF 478
9_pfamImport 136 YAGQF 140
XP_020564134 152 YHGQF 156
4_pfamImport 137 YQGQF 141
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