Conserved Protein Domain Family
GARIL_Rab2_bd

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pfam12480: GARIL_Rab2_bd (This model is not part of the current CDD release)
Golgi associated RAB2 interactor protein-like, Rab2B-binding domain
This domain is found in Golgi associated RAB2 interactor proteins and it is likely a Rab2B-binding domain. Some members included in this entry, such as GAR1A/B and GAR2, are RAB2B effector proteins required for accurate acrosome formation and normal male fertility. GARI-L4 is a RAB2B effector protein required for the compacted Golgi morphology. GARIL5 is a Rab2B effector protein which promotes cytosolic DNA-induced innate immune responses.
Statistics
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PSSM-Id: 520292
Aligned: 37 rows
Threshold Bit Score: 35.7929
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8NEG0         114 ILELTRLLPLMFVKITIHNSVKKQLHLKLATGRSFYLQLCPPSDASEDLF---VHWENLVYILRPPVEAYSDTR 184  human
Q5DTT3        1051 AFEKNASVPIH-TEVHTTDKPT-----------GFNIELVKRVSPASSV--------------QYPMSALEEVQ 1098 house mouse
XP_006254283  1056 AFEKSASVPVH-TEVNTADKPT-----------GFNTELVKQVPPALSI--------------QSPVSALEKVE 1103
6_pfamImport     1 TLEKNTYVPIQTEVVNRSDEPT-----------TFNTELMKQESPATS--------------LRHPVSTFEKAQ 49  
2_pfamImport     1 TFEENTYVPIQSEVVNKTDKPA-----------TFNTELIKQVSPASS--------------LRHPVSAFEKAQ 49  
XP_008246825  1318 TFDKNAYVPVQTEVVNRGDKPV-----------TFNTELIKQVSPTTSI--------------GHPVSTVEKSQ 1366
12_pfamImport    1 TLEKNAYVPIQTEVVNIADKST-----------TFNTELIKQV---------------------SPVSTFEKAQ 42  
XP_014955174  1319 TLEKSAYVPVQTEAVSRADKPT-----------AFNMELTK---QVSPAA-----------SLRHPVSTFEKSQ 1367
XP_021578731  1055 TFEKNACVPM-YSEVNRPDKPT-----------AFDTELMKQVSPPASP--------------RHPISALEKVQ 1102
XP_056655009    94 EVETSNKQGKKLDQLTEYIKTKKLAIIKCLKDHGFLILLTSSALLWDTDFgdeHMNLYALFLFPSSLTTGRKEp 167  gray short-tailed ...
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