Conserved Protein Domain Family
PKK
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pfam12474: PKK (This model is not part of the current CDD release)
Polo kinase kinase
This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam00069. Polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation. This family is Polo kinase kinase (PKK) which phosphorylates Polo kinase and Polo-like kinase to activate them. PKK is a serine/threonine kinase.
Links
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Statistics
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PSSM-Id: 520291
Aligned: 50 rows
Threshold Bit Score: 81.0739
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_046448450   886 AQVARDQQERRFDQETTSLLRGYDTELETMTRSQKQQVERAEQQQDSDLRISSKKIRSEQERELKLFREGLKQEVRL--L 963 
XP_009031429   381 NKLVKMQLKDSFFLKRNQMMDRQEKEMELCHRANNRQKEELNCSQLIEKKRLPKIQKADCKTRIAMYRQSLKIGSMPp-L 459 
XP_040037000   817 HQLLKQQLKDQYFLQRHQLLKKHEKEQEQMQCYNQRMIEILKARQQQEKNRQPKIQRGEAKTRMAMFKKSLRINST---G 893 
XP_017948158  1315 YQLFRQHITEQHSLQRQQLRKRHEKDMERLKHYQSLLVDDMKSKHTQERSQWQKAQRTEARARQAMFKERVKSQGLS--A 1392
30_pfamImport    1 YHLFKQQVKEQYSLQRQQLSKRHNKDMERASRFQQSLVEEQKSAQAQERGRLLKAQRAESKTRLTQYRQELRKQG----L 76  
31_pfamImport    1 YHLFKQQVKEQFSLQRQQLIKRHSKDKERAMRFHQSLLEEQRSLFAQERARLPRTQRPEAKNRLAQFKLRLKSQG----L 76  
16_pfamImport    1 YQTTKQQIKDQFHLQRHQLVLRHDKEQEQMHRHNKRMKEELLSRQQQERVRLPKIQRTEGKARMSMFKRSIRIQSTYegR 80  
XP_064418938   929 HQLLKQQLKDQYFMQRHQLLKRHEKEMEQMQRYNQRLIEELKNRQTQERARLPKIQRGEAKTRMAMFKKSLRINSL---G 1005 coelacanth
XP_005996976  1402 YHLFKQQVKEQFSLQRQQLLKRHEKETERMNRFHQFLLEDLKGKQAQEKGRLPKFQRNDAKTRLAMFKESLKIQA----I 1477 coelacanth
XP_032221869   859 HQLAKTQLKETFFLQRSQMLNRHLKEVEQHQHLTKLQEEDMKRRHEIERKRLPKIQRNEIKSKTQNYRKSLRVDKQ---M 935  starlet sea ...

XP_046448450   964 KQES--DLLPKDQRKTAFRIKRQQQEVEQSDR-ERSFLDSLNQSHEMSLRRLSDGHREKIALLE 1024
XP_009031429   460 NADEekEKIKMFEEKEKERMKADTQRMLERQKkQKAQLQERINASVKELELIQNEKRRMLIDFE 523 
XP_040037000   894 SSSEdrEKIKQFSVQEDKRQKAERLHLQQKHEsQMRDMIGRCDSNIRELQHLQNEKCHMLVENE 957 
XP_017948158  1393 SEQK--ERSKQFLLQETAYQKSETQRQQQRQEeEMKKLQQHLEETCNELQQIQEEKIQTLQAQE 1454
30_pfamImport   77 TGPEqrHKITQFLAEEESRQKQERSQLQETQEsQLKEVQEQCDANITELQQLQNEKLQVLVEME 140 
31_pfamImport   77 NSQEmrQRLTQFLAEEESRQKEERLSLQQSQErQLRELQEQCDSNIAELQHIQNEKLHVLVEWE 140 
16_pfamImport   81 TQQSekDKIKQFTVAETKRQKSERIKLQIKHEaQIKEMDARIEANLRELTQLQNEKRRIVVEHE 144 
XP_064418938  1006 SPEQdrEKIKQFAAQEEKRQKNERLSQHQKHEnQMRDLQLQCDANARELQQLQNEKCHLLIEHE 1069 coelacanth
XP_005996976  1478 SAPEqrEQIKQFHQQEEARQKAEIQQQQQKHEaQLTELQEQLNSNISELQQLQNEKLHLLVDRE 1541 coelacanth
XP_032221869   936 SLEDekELMRTFEEAERKRAKSEYEKMLIRQDlEVEELRTTTESALKELQQLQNEKRHMLMESE 999  starlet sea anemone
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