Conserved Protein Domain Family
GTP_CH_N
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pfam12471: GTP_CH_N (This model is not part of the current CDD release)
GTP cyclohydrolase N terminal
This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. This family is the N terminal of GTP cyclohydrolase, the rate limiting enzyme in the synthesis of tetrahydrobiopterin.
Links
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Statistics
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PSSM-Id: 520289
Aligned: 63 rows
Threshold Bit Score: 309.849
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
KDE06338           147 QRVILTTYPNQVGISPVPLKWGAPSAMERGPVIASRhaLSIKKRNAIGAYAGSYSVYRALACAQGLIDPNHRPDYTNTEP 226
2_pfamImport         1 NHIRLTSHP-DGQAPGVPLRWGESEPLRRGPVVATL--SDPANRNVIGTHSGAYSIYRALAVSAGKLPQDHKADLTNTSP 77 
WP_015927220         8 THIRLTSHP-EPRAARWPIRWGAADPRERGPVIGTV--TNPADRNVIGANGGAYSLYRALAIAGRALNPLARPDLTNTHP 84  Methyloba...
WP_011924888         8 DHIRLTSHPVPGAKHNFPLHWGAASARERGPVIGTV--SRPQDRNVIGSHGGSYTVYRALAVSSGALDPIRRPDLTNTHP 85  Bradyrhiz...
WP_014101880         9 SHIVLTSHPPKDGKIP-KITWGAKTLAERGPLIASM--ADHAASNVIGAYAGAYSVYRAVAVATGELDPLHVPDLHNTSP 85  Micavibri...
Q0K0U2               3 DHIVLTSHA-RRDKPAEPIHWGAPTAAERGPVIASL--ANPAQRNVIGTHAGAYAIYRALAVAAGALQRDHRTDLTDTAP 79  Cupriavid...
WP_013901450         9 RHIRLTSH--SGGTGALPVRWGAATPAERGPVVGTT--GQRSHRNVIGTHSGSYSVYRALAVAAGALSRQHRADLTNTSP 84  Ramlibact...
WP_011729093        19 RHIRLTSH--HGAEGALAIRWGAPTAAERGPLIGTT--TTRAHRNVIGTHSGSYSVYRALAVASGALSPEHRADLTNTAP 94  Mycolicib...
WP_019510191        17 RHIRLTSH--SGGPLAPPIRWGAPTAAERGPIVGTT--GNRAHRNVIGTHSGSYGVYRALAVAAGALSPQHRADLTNTMP 92  Mycolicib...
zhongguo:AS9A_2332  37 GHIRLTSH--SGSARAPSINWGAAAPSDRGPIIGTT--STRAQRNVIGTHSGSYSVYRALAVAAGALSREHRADLTNTAP 112

KDE06338           227 PIDIKWNPSWDDKSKIVSIDPYGHLAPQVFKSYFDAGLDIRPTISITKAHIKLLDMDEAVRSGALQVDGKIVVKTptewi 306
2_pfamImport        78 AAQVGPHPAWSDPKRIVSLDPWGAVASQVFRAYAEQGVDYRPTIAVTRAHINMPEVREAMAAGRLKVDGDLVAAN----- 152
WP_015927220        85 VVPIGPHPQWAEPDRIVSLDPWGHLPGEIFAREIATGTDIRPTIAVTKARLGLPEILAAIGAHRLAPDGSILHAS----- 159 Methyloba...
WP_011924888        86 AATIGPFDQWRDPAKIVALDPWGHLVAENFGGEIAEGIDIRPSIAVTKARIELPELHAALAAKRLVHDGSVVHAN----- 160 Bradyrhiz...
WP_014101880        86 PVKIGPHEQWFEPGKIVSLDPWGHMVGEAFEDYRQKGLDVRPTIAVTRAHINIPEIHDAMRAGRLKPDGKILKEN----- 160 Micavibri...
Q0K0U2              80 AEAIGPHPQWGDPEKIVSLDPWGHLVSTVFADRIAAGVDIRPTIAVTRAHINMPELMSAIAAGRLKPDGDILHAN----- 154 Cupriavid...
WP_013901450        85 TDPIGPYPQWSDPGKIVSLDPWGADVAQVFAGEIAAGYDVRPTIAVTKAHVILPEVIEALQKGRLKADGKFLTAG----- 159 Ramlibact...
WP_011729093        95 TDVIGPYAQWSDPSAIVSLDPWGAMVAEAFTTELAAGFDIRPTIAITKAHVILPEIADAIAKGRLQPDGRILLPN----- 169 Mycolicib...
WP_019510191        93 TDVIGPHPQWQNPEAIVSLDPWGAAVADVFADQLAADHDIRPTIAVTKAHVMLPEVAEAMQKGRLVPDGTVLLDG----- 167 Mycolicib...
zhongguo:AS9A_2332 113 TAMIGPYPQWWEPGSIVSMDPWGAMIAEAFAHELAAGMDIRPTIAVTKAHVSVPEIAEAVARGRLVPDGRFLLAS----- 187

KDE06338           307 nanraastaaktkrdehdiagqhiehaafdagVELNVNKAALEPVWYLPGIAQRFGITEGALRRSLFED 375
2_pfamImport       153 --------------------------------GDVKVVKAAVEPVWYLPGIAERFGLTEGALRRGLFEH 189
WP_015927220       160 --------------------------------GDIAVTKIAIDPVWYLPGVAARFGTTETALRRTLFEQ 196 Methylobacterium nod...
WP_011924888       161 --------------------------------GSVSVVKIAIDPVWYLPGVAARFGTSETNLRRGLFEQ 197 Bradyrhizobium sp. O...
WP_014101880       161 --------------------------------GDVRVTKAAIDPVWHLPGMAARLGVDEHDLRRSLFEN 197 Micavibrio aeruginos...
Q0K0U2             155 --------------------------------GDVRVTKAAVDPVWYLPGLAARFGIKESVLRRSLFEQ 191 Cupriavidus necator H16
WP_013901450       160 --------------------------------GAALVTKAAIEPVWWLPGVAKRFGCSETDLRRVLFEE 196 Ramlibacter tataouin...
WP_011729093       170 --------------------------------GAALVTKAAIEPVWYLPGVAARFGCSETTLRRVLFEE 206 Mycolicibacterium sm...
WP_019510191       168 --------------------------------GAAVVTKVAVEPVWYLPGVAARFGCTEAALRRALFEE 204 Mycolicibacterium ne...
zhongguo:AS9A_2332 188 --------------------------------GAAVVTKVAVEPVWYLPGIADRFGCTETELRRVLFEE 224
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