Conserved Protein Domain Family
SUFU_C

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pfam12470: SUFU_C (This model is not part of the current CDD release)
Suppressor of Fused Gli/Ci N terminal binding domain
This domain family is found in eukaryotes, and is typically between 192 and 219 amino acids in length. The family is found in association with pfam05076. There is a conserved HGRHFT sequence motif. This family is the C terminal domain of the Suppressor of Fused protein (Su(fu)). Su(fu) is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade. It functions by binding these proteins and preventing their translocation to the nucleus. The C terminal domain is only found in eukaryotic Su(fu) proteins; it is not present in bacterial homologues. The C terminal domain binds to the N terminal of Gli/Ci while the N terminal of Su(fu) binds to the C terminal of Gli/Ci. This dual binding mechanism is likely an evolutionary advancement in this signalling cascade which is not present in bacterial homologues.
Statistics
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PSSM-Id: 520288
Aligned: 14 rows
Threshold Bit Score: 248.486
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002429835 244 IEKGIETEGSNLGGVSAKCSWIEkdfdiecslheqssiiaksE----------LGGPRISEQ----ESQQIKSELKK--- 306
4_pfamImport   1 VDEGIEADGSNLSGVTANCAWSE-------------------Nf---------VVNQKSCQNflvtVGDQYHSEFLRyni 52 
XP_029343842 255 ITEGIKTEGSNLCGISAHCSWEElnnrcdkala--------------------------------------------yns 290
XP_046439311 269 VEHGIDRDGCSLSGVSARCHWEErkvtsk--------------------tgsawrSPEAEDDsssqDDEEDEPEAGAtlg 328
XP_001953664 253 LQDDLEKQGSDLAGVNAEFSFRElkpkkevkkevdfhalsekCan-------eENNRPLTESlfkrEEPSFPQSMSIssn 325
1_pfamImport   3 LQDDLEKQGSDLAGINADFTFKEtkptivkqe-vdfqslserCat-------eENNRPMTESqmkrEEPSFPQSMSLssn 74 
XP_001842898 245 LEIDLEKEGSDLAGVNADFTFKElpki------------tikKeivd---peeEITKCISSCnieiKKEFN--DGLEhsg 307
Q7PYI0       251 LELDLEKEGSDLAGVNADFTFKElakgal--------tvavkKevld---pdeDLSRSISSCniavKEEANEKDTLEqst 319 Anopheles gambi...
XP_001601038 277 VQSGIAREGSNLSGVSAKCWWVQmgdkstqkyreqrqesdeeDdgelepeeeiDIKPNIKSErlspCEQDVKMSVEQds- 355
XP_052705073 268 VEQGIETEGSNLSGVNSRCSWEEpgengddyynedmkdnrtvDerrn---sneIDRPRISDF----ESEQIKATLQK--- 337
XP_002429835 307 ------GL----LsskpginnsliktedfedfdryvlfflpnvsvrksdimfqgnfaestelvHVVHLEGIHLTFNLESG 376
4_pfamImport  53 frfvtiKLliltNfyrgrnslglg-----------------------------nsgfettellQTKVLENVHLTFNLESG 103
XP_029343842 291 vehsmnNLriinNsrapnedlketdg------------------------nsnykscelselnQGQFIENVHITFNLEAG 346
XP_046439311 329 rhrpadGEptinGeiw----------------------------------------------piRRLYKGVHLTLNLEAA 362
XP_001953664 326 slhkscPLd--fQpla----------------------------------------------pnCISLDGIEITLAPNVA 357
1_pfamImport  75 slhkscPLd--fQpqa----------------------------------------------pdCISLDGIEITLAPTVA 106
XP_001842898 308 ---ssdMVnpfnHsqv---------------------------------------------psRVSPLNGIELTLAPYAA 339
Q7PYI0       320 gstssdMVnpfdNpni---------------------------------------------psRVFPLTGIELTLAPYAA 354 Anopheles gambi...
XP_001601038 356 -----nGL---------------------------------------------------------KTLMGLHLTFNLEAG 373
XP_052705073 338 ------GLqfprrdsrefeydntrr---------------------kqsfdsigssegptellRTRTLDFVHLKFNLEAG 390
XP_002429835 377 ILLPLALRGRVKHGRHFTFKSVLGDTAITFVASSVTGTFVNSDHPYAAHGPWLQVLIPDDFATEMITDIEMLnQ-NTDEI 455
4_pfamImport 104 SLLPLAIRGRVKHGRHFTFKSACSPIAITFVAESVTGSFVDVDKPYVAHGPWLQLLLNEDSSNQLLEKLQPLiS-HPEQI 182
XP_029343842 347 LLLPFVLKGRIRHGRHFTFKALTGDATITFVASAVSGSLVSEEKPFVAQGSWLQVLVSNSFLDSMESSLKFL-N-EPVME 424
XP_046439311 363 SLLPVVLRGRLRHDRHFTFKAVAGETAVTLLTGRVGGALASPSAPLVAKGPWLQILVDSEWLAKLESDLACL-Q-QPDGV 440
XP_001953664 358 KYLLLAIKDRIRHGRHFTFKA--QHLALTFVGETVTGCAVSKKEPYGVLGYWVQVLIPEDLVPRMLEAFRGAgLnETCEP 435
1_pfamImport 107 KYLLLAIKDRIRHGRHFTFKA--QHLALTLVAETVTGAAVSVHEPYGVLGYWIQVLIPNDLVPRMMDDFRNAnLdENTEL 184
XP_001842898 340 KFLVLAIKDRIRHGRHFTFKA--QNMAVTFVSESVTGSIVTKDSPYGVLGYWVQILIPNALIPKMIDTFSDLnS-SVDNL 416
Q7PYI0       355 KFLMLAVRDRIRHGRHFTFKA--QHMAVTFVAESVTGSIVNRQTPYAVLGSWVQILIPNRLVPRMVERFGELsTrSADGL 432 Anopheles gambi...
XP_001601038 374 TLLPLAIKGRVMHGRHFTFKSILSHAAVTLVPPSVTGTFATKEKPYAVQDPWLQVLLPDELTERMAQEFQVL-N-APEQL 451
XP_052705073 391 SLLPLALKGRLRHGRHFTFMSALNDTAVTLVSTSVNGSIADENHPFAAHGPWLQVLLTDDFIEEMIVDTEEL-V-HPDEI 468
XP_002429835 456 TFPKTFAWPDRKIVITI 472
4_pfamImport 183 MLPQTYTLNDKKLSITI 199
XP_029343842 425 PLPKTVNWPDRNLTITI 441
XP_046439311 441 VVPKTFCWFDRQMALTV 457
XP_001953664 436 AQRIELEWPDKNLKLIV 452
1_pfamImport 185 TQRLQFDWPDKNLRLIL 201
XP_001842898 417 KIPLTYEWPEHNLKFII 433
Q7PYI0       433 KIPLTYEWPEQNLKFII 449 Anopheles gambiae str. PEST
XP_001601038 452 QLPKTFTWPEYKLAITI 468
XP_052705073 469 MCPKTYSWPERRLMITI 485
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