6TC0,8USP


Conserved Protein Domain Family
MMS19_C

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pfam12460: MMS19_C (This model is not part of the current CDD release)
RNAPII transcription regulator C-terminal
MMS19 is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription. This C-terminal domain, along with the N-terminal, MMS19_N, form part of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly. This domain has a HEAT-like repeat structure.
Statistics
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PSSM-Id: 520281
Aligned: 79 rows
Threshold Bit Score: 220.972
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6TC0_C        560 CLQALSAVST-HPSIVKETLPLLLQHLCQANKGNMVTESseVVA--VCQSLQQVAE-----KCQQDPESYWYFHKTAVPC 631  house mouse
XP_004181717  571 ILKVILDFTTsRHCLVKESIIGLSHKLFSVVKYENSKLD--CFM--IISTIFSLFEn---nFAQFDEETADSIKTEIEPL 643 
XP_011275676  552 IFEVLKSITR-DKQLGDWVLEKLIKKLSELN--ELDNVY--GFE--ISETCLVILKe----IQRLSPFDTDLYLKTLYPQ 620 
XP_006686843  597 YVEVLDSVVV-SSQLLEVVSIRLVNRL------SNDRDF--NSK------IIELLGslvmkVQKRSQFLMNSWFKGIVPK 661 
XP_007376066  584 RLAVIGKLCV-NYAILEVISIKSLARLSSFN--NLDLAH--EDKikLFHVVIDTLIklinqVTERHQFLTDSWYGHFVPP 658 
XP_036667317  628 ALDIIQQLTI-NHQILEVVSIRIMNKQNFTLD--------------SLQIVVEFFVtlfnkVETIQPFLTNSWYKKFIPN 692 
XP_002547872  595 ILSLVGDLCV-NYQVLEVISIRLLNKL------SAVNSS--ANKfqLYKIIIQLFIklinqIERIQQFLTNSWYKNFIPT 665 
XP_001527357  652 ILTLVGDMCV-NNQILEVISIRLIG--------MGSIEP--RQFciIVEQLYVLIEk----VQLIKQFLTTSWYGNFVPR 716 
XP_001382440  610 ILDIIGDLCI-NYRILEMLSVRLLNRLIAIS--QSDKDI--EIKvnLFQNIVESLTkwftkVQTSKQFLTNSWYHNFLPK 684 
Q6BYJ0        617 LLEIIGELCT-NYQFLEVLSIRLLNRLT-----NYDQFN--IDQfeVFRNITNLLVesikkVQVSKQFLMNSWYKNFVPR 688  Debaryomyces ...
6TC0_C        632 LFALAVQASmpEKESsvlRkvllEDEVLAALASVIGTATTHLSPELAAQSVTCIVPLFLdgnts-flpenSFPDqFQPFQ 710  house mouse
XP_004181717  644 MIKSALNYPtlMDDNy----------NLLLLANTLFFINLKISKTNSTTELSKIVNLFIv----------E--QnILET- 700 
XP_011275676  621 LLDI---LDknHSNDe----------FLESIGDLIKLIIVYSKKNLHQEILDDSINKFI------------YEKgLITGS 675 
XP_006686843  662 LLNQAAEVEasGVNNs--D----NWHYLELISVLLGFVIKYYDSPKHQGILDDFQSAFYknka---ksglKLSGyTILEV 732 
XP_007376066  659 FLNNIFKLLgeDTRDy---------ALIESSSRLVGLIIRYIEKSKHQAVLNDFIEVFTteks----skiKLEGnLIG-Q 724 
XP_036667317  693 FMQLLYNLVptDANDe--A----SLALLEVSGDLLRIIVRFIDVTKHQAILNEMESIFCtdgds--ksvfQYQGnLLN-Q 763 
XP_002547872  666 FLHNVLTIVpvGENEe--E----QFEILDLTGDLLGLIVKFIDVSKHQSIFDEMFTAFFtnett--hgsfAYPSnLLE-T 736 
XP_001527357  717 FMQMVNKMVeiDSQDy---------ILVEKIGDLLKIIIRFIDRAKHQHVLDEAYHAFFtstsdgstntfQYNSnLIE-T 786 
XP_001382440  685 FFESVFRLLtlHPDYv----------LVELCGDLVGLIVKFIDQSKHQEILDDFVEAFFt----------SASSkIIGFE 744 
Q6BYJ0        689 FINCLLEILkvKDDHi----------LIELSGDLIGLIVKYNDKSKHQEILNDFVAMFLldka----ngfNVNVnVIHQQ 754  Debaryomyces ...
6TC0_C        711 D-G--SSgqrrLVALLTAFVCSLPRNvEIP-----QLNRLMRELLKq----SCGHSC-PFSSTAATKCFAGLLNKQPPGQ 777  house mouse
XP_004181717  701 PsR--------LVILFVKLLSSLDKEcEf-----sQANEIVTKVLYll--kDNNSKItEFEKLGYLELLALISNKWLCDK 765 
XP_011275676  676 PnK--------LINIFVKIIAGLDKIvIFP-----KVDEFLDDLIKftelnSNELNKePYTKLGYLQLISLIMNKFISND 742 
XP_006686843  733 AsP--------MVLVFNNVLSNIDKSt--------NLSIQLEDLVRli--eTTSNLRdPILKVNYLQHLCLLVNKFYKDD 794 
XP_007376066  725 PsG--------YIVMFNKIVASIDKEcQf-----eNLNVITESMVG-----IVKSVNnEYLRIQYLEGISLLVNKFTTD- 785 
XP_036667317  764 PsG--------YMSIYNKIVSAIDKScKl-----tSVATSLDAVTT-----ILSNLHgKYLRVQYLQHLCLLVNKFGPVE 825 
XP_002547872  737 PsF--------YVNVFCKILSSTDKScVf-----aNYKPIITSCLQvv--sDLKDTRsL--RIQYLLAISLMFNKIATDE 799 
XP_001527357  787 PtA--------YISIFNKILSAIDRScKl------NTASSLDSVTR-----LIPTLTnEYLRVQYLLNLCLHINKFVSDS 847 
XP_001382440  745 RnAldEAv--pAIGIFNKAIANVDKAvKIKt---fSPAEYLSKVCDv----IYTVEDdQFLRIQYLQTLAILVNKFAEDE 815 
Q6BYJ0        755 Kp---------LINLFNKILANIDKAcVvqlndtfTMNELTDRIIG-----LCNSRGdEYSRLGYLQNLSLLVNKFLQSN 820  Debaryomyces ...
6TC0_C        778 --QLEEFLQLAVGTVEAGLASES------SRdqaFTLLLWVTKALVLRYHPLSACLTTRLMGLL----SDPELGCAAADG 845  house mouse
XP_004181717  766 evLAH---CNFVDNSPSN----------------LELLIWLCKGLTMRNSNNASRFYDLFISLL----SSSDIGLYVSKC 822 
XP_011275676  743 skYINYL-DNSDGISSIN----------------LEIFTWITKSIVLKMSSESENYITILFNYL----SNEEFGLIITKS 801 
XP_006686843  795 dsLQPVVEKLYDLQQPSN----------------FEISVWIIKALMLRLSKVGIEYLTKLLEVLdhdaSQATI---VLRS 855 
XP_007376066  786 ----------VTSLVDMSLTDPIs----------YEIYIWILKGLILKLDPVGLDKLQQLVNQFtsgsSGI-----TPKS 840 
XP_036667317  826 efSPELSFSDMNQ---------------------FEIYVWTLKAHLMKIDQSGMVSLTELMQTFqsstTAPQHKQLIISA 884 
XP_002547872  800 qfIEEHL------ILPQQLTSDTlsdeflIQ---FEQSIWILKGLIVKLDNAGMKALDNLLHIFds-tDNLALMNAISKS 869 
XP_001527357  848 svIDMGIETDELEQLDK-----------------FEIYLWKLKALVMRVDKAGIEGLSHLLKLFnsyeTSISSRQLIAKS 910 
XP_001382440  816 saIEGKMGEFIGHFTQLTSNSKLsqkdyiT----FEILIWYIKALVLKVHKLGFEYVNNLVQLLst-sSNLETKELVGRS 890 
Q6BYJ0        821 efIEEKLKLTFENILNISKFDSVlsqdqiES---FEVIVWILKSLILKIDTLGIEYINRLISLLs--cENRQMQQLTAKS 895  Debaryomyces ...
6TC0_C        846 FSLLMSDCTd------------VLTRAGHADVRIMFRQRFFTDNVPALVQGFHAAPQDV------KPNYLKGLSHVLNRL 907  house mouse
XP_004181717  823 FEIFVIDLSsf---------qkYKGVTWTNNVNILYKQKLFSDIFKRLVTLYQSSTEMYi-----KRNCLTALSLILRHT 888 
XP_011275676  802 FEILVIDLNnf----------eKFKKKQNNNVRLLYKQSFFQIITPLLISGFQQTQDLKt-----KSNYLTSLSYILKHI 866 
XP_006686843  856 FDIILRDLKifspnkelpkgskIISKVNHLNTRSLYKQQVFNIVLAKVLQQPE------------NEIHLQLLAVLTKNI 923 
XP_007376066  841 FRVLFIDIDifte-----ttskHISGVRNLNVRLLYKQRIFQIVVPELLPHVD------------NHNCLVALALIIENV 903 
XP_036667317  885 LPLLVIDVKlfintpaalasrkVISKVNNLNVKLLYKQQVFEQLLPYLMDENDSKTD--------AMVNIQALAMILPHI 956 
XP_002547872  870 LHILFIDLKiftnstpdikqnkIISKVKNLNIKLLYKQQIFVKVLPYLINSETN-----------FNIKFYALSLVIENL 938 
XP_001527357  911 LSVLFIDTSiftnp---plpkkIISKVTNLNVKLLYKQHLFEIILPYLTLDIGETEAGVdspisdFDLKFYALANICENV 987 
XP_001382440  891 LMILFTDLKvftnqt--pgikkVISKVTNLNVKLLYKQRIFEVILPALVDNHKNSEN--------SEIYLNSLSLILKNL 960 
Q6BYJ0        896 FNILMIDLPiftnqq-iggktkIISGVQNLNVRLLYKQKVFGILLPKIIEGYNISNIRN------KENYLISLSLILNNV 968  Debaryomyces ...
6TC0_C        908 PKPVLLPELPTLLSLLLEALS-CP----DSV------------------------V-QLSTLSCLQPLLLe--APQIMSL 955  house mouse
XP_004181717  889 SSKLIEPYMLELFPLLLQALE-MQ----DSE------------------------V-KASALESIKAAAEk--HSKLIVE 936 
XP_011275676  867 KREIIIPHLSSFFPLLLQAIS-LP----KSE------------------------V-RYASINTILSTIDe--IPDLVSS 914 
XP_006686843  924 DSHVLKSRINDIIPLTIQSIQ-LNt------------------------------L-LDTSLETLLIIID----SNNLQN 967 
XP_007376066  904 STSILIRYLSTLGPVIMACVNeTT----NAV------------------------V-LKSGLSMINVVLEe--DDTILDP 952 
XP_036667317  957 SHKILVPHLSTFTPFVITALT-MTttttTTTttttttttttttknchasreniqlI-YRAGLNILEIILRe--DATMMQS 1032
XP_002547872  939 STNILINNLQEVLPIVLKSFQ-------NSE------------------------LnKKSSLLILSIILKe--NESILSP 985 
XP_001527357  988 PTNVLAPHLAELSPLVLKALKsMSttvgSEVs----------------------pIvIKSSLHILRNILEhgdKSTIDNL 1045
XP_001382440  961 SRSILVSHLKEILPLVLTSLT-LPksrlNST------------------------I-LRSSLNTLFIIIEe--DQSIVEG 1012
Q6BYJ0        969 PHSILKSYLSQILPLILNSLN-LP----NPI------------------------I-LNASLATCEIIIDe--SPDLVIP 1016 Debaryomyces ...
6TC0_C        956 --HVDTLVTKFLNLS---------SSYSM---AVRIAALQCMHALT 987  house mouse
XP_004181717  937 --HFDTIVPLLLTSVsp------eQYNNL---NVRLYSLQLLELLT 971 
XP_011275676  915 --HLSTLIPKFLEMSqhk----ntRLNNE---KVRLICLQVLEALV 951 
XP_006686843  968 --FMPLLVKRLMVLSntkvvennrIVNTE---RIRYLSLKCLLELL 1008
XP_007376066  953 --YVTQLVPVLLQIAttkivsgkkRINDE---SIRVLALRNLTILF 993 
XP_036667317 1033 --HLSKIVPQLMQLAtn------sTTNGSc-pQIRELALQNLILVF 1069
XP_002547872  986 d-DILRLVPVLVELSntsk-----------leaIRVSSLGNLLLIV 1019
XP_001527357 1046 hlELGDLLSILLKLStred--iekSESSNsgeEIRRLGLIDLGLIF 1089
XP_001382440 1013 --SLAKLIPILLTLAtgkifyrkkLINTE---EIRILALQNLIIIF 1053
Q6BYJ0       1017 --HLSTLIPKLVGLSmgkivveksLVNNE---EVRLTSLNCLQKVF 1057 Debaryomyces hansenii
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